抗肝纤维化的中药有效成分及其作用机制研究进展

孙蕾; 邓华平; 席忠新; 李霞; 孙连娜; 孙蕾; 邓华平; 席忠新; 李霞; 孙连娜

doi:10.3969/j.issn.1006-0111.2012.02.004

[1]

Lamireau T,Desmouliere A,Bioulac-Sage P,et al.Mechanisms of hepatic fibronegesis[J]. Arch Pediatr, 2002,9(4):392.

[2]

Pinzani M,Rombouts K.Liver fibrosis from the bench to clinical targets[J].Dig Liver Dis, 2004,36(8):231.

[3]

程君,杨云霞.黄芩苷对四氯化碳致亚急性肝纤维化小鼠的保护作用[J].华西药学杂志,2010,25(1):32.

[4]

刘世杰,姜宏齐,马英杰.黄芩苷通过抑制大鼠转化生长因子β1的表达发挥抗肝纤维化作用[J].哈尔滨医科大学学报,2011,45(2):128.

[5]

王新华,金东岭,何红梅,等.黄芩苷对抗结核药物肝损伤保护作用的实验研究[J].时珍国医国药,2009,20(7):1640.

[6]

何蔚,曾繁.灯盏花素对异丙肾上腺素引起大鼠心肌肥厚和纤维化的保护作用[J].中国药理学通报,2005,21(12):1514.

[7]

杜钢军,王梅,林海红,等.灯盏花的肝纤维化保护作用[J].河南大学学报,2009,28(3):170.

[8]

Wilmsen PK,Spada DS,Salvador M.Antioxidant activity of the flavonoid hesperidin in chemical and biological systems[J].J Agric Food Chem,2005,53(12):4757.

[9]

Yeh CC,Kao SJ,Lin CC,et al.The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro[J].Life Sci,2007,80(20):1821.

[10]

吴芙蓉,李俊,任丹阳.橙皮苷抗大鼠肝纤维化作用的实验研究[J].安徽医科大学学报,2011,46(4):358.

[11]

杨慧莹,林克荣.水飞蓟素治疗脂肪肝的作用机制[J].中华现代内科学杂志,2006,3(8):876.

[12]

曹立波,李兵,李佐军,等.水飞蓟素对肝纤维化小鼠的保护作用及机制探讨[J].中国药理学通报,2009,25(6):794.

[13]

Tsai JH,Liu JY,Wu TT,et al.Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats[J].J Viral Hepat,2008,15(7):508.

[14]

王建生,张海,牛瑞云.苦参素注射液治疗肝纤维化临床探讨[J].实用中西医结合临床,2003,3(4):29.

[15]

张晓芸,崔晓栋,郭军堂,等.苦参碱对血小板衍生生长因子介导的大鼠肝星状细胞迁移、增殖和凋亡的影响[J].中国慢性病预防与控制,2008,16(4):334.

[16]

梁建新,屈杏芬,曾文铤,等.氧化苦参碱治疗慢性乙型肝炎肝纤维化的作用机制[J].中国老年学杂志,2010,30(11):1505.

[17]

Shi GF,Li Q.Effects of oxymatrine on experimental hepatic fibrosis and its mechanism in vivo[J].J Nat Med,2011,9(6):0473.

[18]

Cai XH,Wang S,Chen BA.Reseaech advances on the pharmacological effects of tetrandrin[J].World J Gastroenterol,2005,11(2):268.

[19]

Hsu YC,Chiu YT,Cheng CC,et al. Antifibrotic effect of tetrandrine on hepatic stellate cells and rats with liver fibrosis[J].J Gastroen Hepatol,2007,22(1):99.

[20]

王拥泽,杨宏志,杨沛华.川芎嗪抗肝纤维化作用机制研究[J].河北中医药学报,2006,21(3):8.

[21]

马进,郑仕中,陆茵,等.川芎嗪抑制肝纤维化作用机制的研究进展[J].中国临床药理学杂志,2010,126(5):395.

[22]

Sue YM,Cheng CF,Chang CC,et al.Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethlpyrazine against gentamicin-induced apoptosis in murine renal tubular cells[J].Nephrol Dial Transplant,2009,24(3):769.

[23]

杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝组织中I型、III型胶原表达的影响[J].河南中医,2009,29(7):654.

[24]

杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝脏星状细胞凋亡和增生的影响[J].河南中医,2009,29(5):447.

[25]

来丽娜,杨柳絮,郭春花,等.青蒿琥酯抗大鼠免疫性肝纤维化的作用及机制研究[J].中国药理学通报,2011,27(1):125.

[26]

沈晓丹,曹莉,顾艳,等.蓝萼甲素体外细胞毒活性研究[J].中华中医药学刊,2011,29(6):1334.

[27]

Gao LW,Zhang J,Yang WH,et al.Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway[J].Toxicol in Vitro,2011,25(1):51.

[28]

Liu Q,Wang X,Zhang Y,et al.Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellar matrix production[J].Acta Pharmacol Sin,2010,31(7):839.

[29]

徐标,童巧霞.葫芦素B对小鼠日本血吸虫肝纤维化组织VEGF及氧化应激的影响[J].中药药理与临床,2009,25(6):33.

[30]

余万贵,张恒文,贺尚荣,等.三七总皂苷对肝纤维化小鼠血清中转化生长因子β₁及白介素-1的影响[J].时珍国医国药,2006,17(1):54.

[31]

曾文勇,石小枫,刘杞,等.三七总皂苷对肝纤维化大鼠胶原及TGF-β₁mRNA表达的影响[J].胃肠病学和肝病学杂志,2010,19(9):795.

[32]

欧阳灿辉,朱宣,张焜和,等.熊果酸对肝纤维化大鼠肝组织TGF-β₁和α-SMA表达的影响[J].世界华人消化杂志,2009,17(22):2237.

[33]

Asl MN,Hosseinzadeh H.Review of pharmacological effects of Glycyrrhiza sp. and its bioactive comgpounds[J].Phytother Res,2008,22(6):709.

[34]

Moro T,Shimoyama Y,Kushida M,et al.Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis[J].Life Sci,2008,83(15-16):531.

[35]

Dang SS,Wang BF,Cheng YA,et al.Inhibitory effects of saikosaponin-d on CCl₄-induced hepatic fibrogenesis in rats[J].World J Gastroemterol,2007,13(4):557.

[36]

Fan J,Li X,Li P,et al.Saikaosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury[J].Biochem cell biol,2007,85(2):189.

[37]

Tsai MK,Lin YL,Huang YT.Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats[J].Toxicol Appl Pharmacol,2010,242(2):155.

[38]

Lv Z,Song Y,Xue D,et al.Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells[J].J Ethnophacol,2010,132(2):384.

[39]

Yu MF,Zhou Y,Zheng S,et al.The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione inpassaged rat hepatic stellate cells[J].Lab Invest,2006,86(7):697.

[40]

Yasuda Y,Shimizu M,Sakai H,et al.(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R[J].Chem Biol Interact,2009,182(2-3):59.

[41]

Chávez E,Reyes-Gordillo K,Segovia J,et al.Resveratrol prevents fibrosis,NF-κB activation and TGF-β increases induced by chronic CCl₄ treatment in rats[J].J Appl Toxicol,2008,28(1):35.

[42]

Choi JH,Choi CY,Lee KJ,et al.Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice[J].J Med Food,2009,12(2):320.

[43]

Choi JH,Hwang YP,Choi CY,et al.Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats[J].Food Chem Toxicol,2010,48(11):3137.

[44]

徐波,陆茵,吴佳明,等.姜黄素抗肝纤维化分子机制研究进展[J].中国中医药信息杂志,2008,15(3):9.

[45]

Shu JC,He YJ,Lv X,et al.Curcumin prevents liver fibrosis by including apoptosis and suppressing action of hepatic stellate cells[J].J Nat Med,2009,63(4):415.

[46]

Fu Y,Zheng S,Lin J,et al.Curcumin protects the liver from CCl₄-caused injury and fibrogenesis by attenuating oxidative stess and suppressing inflammation[J].Mol Pharmacol,2008,73(2):399.