[1] |
Collaboration HLT.Lowering blood homocysteine with folic acid based supplements:meta-analysis of randomized trials [J].BMJ,1998,316(7135):894. |
[2] |
Selhub J,Jacques PF,Wilson PW,et al.Vitamin status and intake as primary determinants of homocysteinemia in an elderly population[J].JAMA,1993,270(22):2693. |
[3] |
NOStuart JM,Derek L,Ian FW,et al.Folate, homocysteine, endothelial function and cardiovascular disease[J].Cire Res,2000,87(5):840. |
[4] |
Gottsater A,Forsblad J,Mattiasson I,et al.Decreasing plasma endothelin-1 and unchanged plasma neopterin during folate supplementation in hyperhomocysteinemia[J].Int Angiol,2002,21(2):158. |
[5] |
McCully KS.Vascular pathology of homocysteinemia: implications for the pathogenesis of arteriosclerosis[J].Am J Pathol,1969,56 (1):111. |
[6] |
Wilcken DE,Wilcken B.The pathogenesis of coronary artery disease. A possible role for methionine metabolism[J].J Clin Invest,1976,57 (4):1079. |
[7] |
Ward M.Homocysteine,folate and cardiovascular disease[J].Int J Vitam Nutr Res,2001,71(3):173. |
[8] |
Homocysteine Lowering Trialists' Collaboration.Dose-dependent effects of folic acid on blood concentrations of homocysteine: a meta-analysis of the randomized trials[J].Am J Clin Nutr, 2005,82(4):806. |
[9] |
Homocysteine Studies Collaboration.Homocysteine and risk of ischemic heart disease and stroke:a meta-analysis[J].JAMA,2002,288(16): 2015. |
[10] |
Kelly PJ,Rosand J,Kistler JP,et al.Homocysteine, MTHFR 677C→T polymorphism, and risk of ischemic stroke:results of a meta-analysis[J].Neurology, 2002, 59(4):529. |
[11] |
Lewis SJ,Ebrahim S,Davey Smith G.Meta-analysis of MTHFR 677C→T polymorphism and coronary heart disease:does totality of evidence support causal role for homocysteine and preventive potential of folate[J].BMJ, 2005,331(7524):1053. |
[12] |
Sarkar PK, Lambert LA. Aetiology and treatment of hyperhomocysteinaemia causing ischaemic stroke[J].Int J Clin Pract,2001,55(4):262. |
[13] |
Oncel C,Demir S,Güler S,et al.Association between cholesterols,homocysteine and silent brain infarcts[J].Intern Med J,2009,39(3):150. |
[14] |
Homocysteine Lowering Trialists' Collaboration.Dose-dependent effects of folic acid on blood concentrations of homocysteine:A meta-analysis of the randomized trials[J].Am J Clin Nutr.2005,82(4): 806. |
[15] |
Fallon UB,Virtamo J,Young I,et al.Homocysteine and cerebral infarction in finnish male smokers[J].Stroke,2003,34(6):280. |
[16] |
Liu AJ,Guo JM,Xia WL,et al.The new strategies for the prevention of stroke[J].Clin Exp Pharmacol Physiol,2009,37(2):265. |
[17] |
Sánchez-Moreno C,Jiménez-Escrig A, Martín A.Stroke:roles of B vitamins,homocysteine and antioxidants[J].Nutr Res Rev,2009,22(1):49. |
[18] |
Woo KS,Chook P,Chan LL, et al. Long-term improvement in homocystein levels and arterial endothelial function after 1-year folic acid supplementation[J].Am J Med,2002,112(7):535. |
[19] |
Title IM,Cummings PM,Giddens K,et al.Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease[J].J Am Coll Cardiol,2000,36(3):758. |
[20] |
Chambers JC,Ueland PM,Obeid OA,et al.Improved vascular endothelial function after oral B vitamins: an effect mediated through reduced concentrations of free plasma homocysteine[J].Circulation,2000,102(20):2479. |
[21] |
Lonn E,Yusuf S,Arnold MJ.Homocysteine Lowering with folic acid and B vitamins in vascular disease[J].N Engl J Med,2006,54(15):1567. |
[22] |
SEARCH Study Collaborative Group,Bowman L,Armitage J,et al.Study of the effectiveness of additional reductions in cholesterol and homocysteine (SEARCH): characteristics of a randomized trial among 12 064 myocardial infarction survivors[J].Am Heart J,2007,154(5):815. |
[23] |
Ebbing M,Bleie O,Ueland PM,et al.Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography:a randomized controlled trial[J].JAMA,2008,300(7):795. |
[24] |
Albert CM,Cook NR,Gaziano JM,et al.Effect of folic acid and B vitamins on risk of cardiovascular events and total mortality among women at high risk for cardiovascular disease: a randomized trial[J].JAMA, 2008,299(17):2027. |
[25] |
Bφnaa KH, Njφlstad I, Ueland PM, et al. Homocysteine lowering and cardiovascular events after acute myocardial infarction[J].N Engl J Med, 2006, 354(15):1578. |
[26] |
Wrone EM, Hornberger JM,Zehnder JL,et al.Randomized trial of folic acid for prevention of cardiovascular events in end-stage renal disease[J].J Am Soc Nephrol,2004,15(2):420. |
[27] |
Liem AH,van Boven AJ,Veeger NJ,et al.Efficacy of folic acid when added to statin therapy in patients with hypercholesterolemia following acute myocardial infarction:a randomized pilot trial[J].Int J Cardiol,2004,93(2-3):175. |
[28] |
Zoungas S,McGrath BP,Branley P,et al.Cardiovascular morbidity and mortality in the Atherosclerosis and Folic Acid Supplementation Trial (ASFAST) in chronic renal failure: a multicenter, randomized, controlled trial[J].J Am Coll Cardiol 2006,47(6):1108. |
[29] |
Bazzano LA,Reynolds K,Holder KN,et al.Effect of folic acid supplementation on risk of cardiovascular diseases:a meta-analysis of randomized controlled trials[J].JAMA,2006,296(22):2720. |
[30] |
Martí-Carvajal AJ,Solà I,Lathyris D,et al. Homocysteine lowering interventions for preventing cardiovascular events[J].Cochrane Database Syst Rev. 2009, (4): CD006612. |
[31] |
Yang Q,Botto LD,Erickson JD,et al. Improvement in stroke mortality in Canada and the United States,1990 to 2002[J].Circulation,2006,113(10):1335. |
[32] |
Wang X,Qin X,Demirtas H,et al.Efficacy of folic acid supplementation in stroke prevention:a meta-analysis[J].Lancet,2007;369(9576): 1876. |
[33] |
Spence JD.Homocysteine-lowering therapy:a role in stroke prevention[J]. Lancet Neurol,2007,6(9):830. |
[34] |
Antoniades C,Antonopoulos AS,Tousoulis D,et al. Homocysteine and coronary atherosclerosis:from folate fortification to the recent clinical trials[J]. Eur Heart J,2009,30(1):6. |