[1] Jordan J,de Groot PW,Galindo MF.Mitochondria:the headquarters in ischemia-induced neuronal death[J].Cent Nerv Syst Agents Med Chem,2011,11:98-106.
[2] Finkel T.Radical medicine:treating ageing to cure disease[J].Nat Rev Mol Cell Biol,2005,6:971-976.
[3] Fantinelli JC,Perez Nunez IA,Gonzalez Arbelaez LF,et al.Participation of mitochondrial permeability transition pore in the effects of ischemic preconditioning in hypertrophied hearts:role of NO and mitoK(ATP)[J].Int J Cardiol,2011,166:173-180.
[4] Larsen GA,Skjellegrind HK,Berg-Johnsen J,et al.Depolarization of mitochondria in isolated CA1 neurons during hypoxia,glucose deprivation and glutamate excitotoxicity[J].Brain Res,2006,1077:153-160.
[5] Lee DR,Helps SC,Macardle PJ,et al.Alterations in membrane potential in mitochondria isolated from brain subregions during focal cerebral ischemia and early reperfusion:evaluation using flow cytometry[J].Neurochem Res,2009,34:1857-1866.
[6] Dave KR,Bhattacharya SK,Saul I,et al.Activation of protein kinase C delta following cerebral ischemia leads to release of cytochrome C from the mitochondria via bad pathway[J].PLoS One,2011,6(7):e22057.
[7] Moreira PI,Zhu X,Wang X,et al.Mitochondria:a therapeutic target in neurodegeneration[J].Biochim Biophys Acta,2010,1802:212-220.
[8] Diogo CV,Grattagliano I,Oliveira PJ,et al.Re-wiring the circuit:mitochondria as a pharmacological target in liver disease[J].Curr Med Chem,2011,18:5448-5465.
[9] Walters AM,Porter GAJ,Brookes PS.Mitochondria as a drug target in ischemic heart disease and cardiomyopathy[J].Circ Res,2012,111:1222-1236.
[10] Reale M,Pesce M,Priyadarshini M,et al.Mitochondria as an easy target to oxidative stress events in Parkinson's disease[J].CNS Neurol Disord Drug Targets,2012,11:430-438.
[11] Gruber J,Fong S,Chen CB,et al.Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing[J].Biotechnol Adv,2012,31:563-592.
[12] Mukhopadhyay P,Horvath B,Zsengeller Z,et al.Mitochondrial reactive oxygen species generation triggers inflammatory response and tissue injury associated with hepatic ischemia-reperfusion:therapeutic potential of mitochondrially targeted antioxidants[J].Free Radic Biol Med,2012,53:1123-1138.
[13] Telford JE,Kilbride SM,Davey GP.Decylubiquinone increases mitochondrial function in synaptosomes[J].J Biol Chem,2010,285:8639-8645.
[14] Coulter CV,Kelso GF,Lin TK,et al.Mitochondrially targeted antioxidants and thiol reagents[J].Free Radic Biol Med,2000,28:1547-1554.
[15] Modica-Napolitano JS,Aprille JR.Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells[J].Adv Drug Deliv Rev,2001,49:63-70.
[16] Sheu SS,Nauduri D,Anders MW.Targeting antioxidants to mitochondria:a new therapeutic direction[J].Biochim Biophys Acta,2006,1762:256-265.
[17] Skulachev VP.Mitochondria-targeted antioxidants as promising drugs for treatment of age-related brain diseases[J].J Alzheimers Dis,2012,28:283-289.
[18] Smith RA,Porteous CM,Coulter CV,et al.Selective targeting of an antioxidant to mitochondria[J].Eur J Biochem,1999,263:709-716.
[19] Hughes G,Murphy MP,Ledgerwood EC.Mitochondrial reactive oxygen species regulate the temporal activation of nuclear factor kappaB to modulate tumour necrosis factor-induced apoptosis:evidence from mitochondria-targeted antioxidants[J].Biochem J,2005,389:83-89.
[20] Kelso GF,Porteous CM,Coulter CV,et al.Selective targeting of a redox-active ubiquinone to mitochondria within cells:antioxidant and antiapoptotic properties[J].J Biol Chem,2001,276:4588-4596.
[21] Solesio ME,Prime TA,Logan A,et al.The mitochondria-targeted anti-oxidant MitoQ reduces aspects of mitochondrial fission in the 6-OHDA cell model of Parkinson's disease[J].Biochim Biophys Acta,2013,1832:174-182.
[22] Asin-Cayuela J,Manas AR,James AM,et al.Fine-tuning the hydrophobicity of a mitochondria-targeted antioxidant[J].FEBS Lett,2004,571:9-16.
[23] Rodriguez-Cuenca S,Cocheme HM,Logan A,et al.Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice[J].Free Radic Biol Med,2010,48:161-172.
[24] Zelber-Sagi S,Lurie Y,Nitzan-Kaluski D,et al.Mitochondria-targeted antioxidants prevent liver injury in animal models of steatohepatitis and CCl4 intoxication[J].Alcoholic Liver Dis,2006,S267.
[25] Lowes DA,Thottakam BM,Webster NR,et al.The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis[J].Free Radic Biol Med,2008,45:1559-1565.
[26] Ghosh A,Chandran K,Kalivendi SV,et al.Neuroprotection by a mitochondria-targeted drug in a Parkinson's disease model[J].Free Radic Biol Med,2010,49:1674-1684.
[27] Vergeade A,Mulder P,Vendeville-Dehaudt C,et al.Mitochondrial impairment contributes to cocaine-induced cardiac dysfunction:prevention by the targeted antioxidant MitoQ[J].Free Radic Biol Med,2010,49:748-756.
[28] Wani WY,Gudup S,Sunkaria A,et al.Protective efficacy of mitochondrial targeted antioxidant MitoQ against dichlorvos induced oxidative stress and cell death in rat brain[J].Neuropharmacology,2011,61:1193-1201.
[29] Zhao K,Zhao GM,Wu D,et al.Cell-permeable peptide antioxidants targeted to inner mitochondrial membrane inhibit mitochondrial swelling,oxidative cell death,and reperfusion injury[J].J Biol Chem,2004,279:34682-34690.
[30] Wright JS,Carpenter DJ,McKay DJ,et al.Theoretical calculation of substituent effects on the O-H bond strength of phenolic antioxidants related to vitamin E[J].J Am Chem Soc,1997,119:4245-4252.
[31] Schiller PW,Nguyen TM,Berezowska I,et al.Synthesis and in vitro opioid activity profiles of DALDA analogues[J].Eur J Med Chem,2000,35:895-901.
[32] 赵善民,何显教,晋 玲,等.急性低氧对家兔血压心率微血管反应性及自由基的影响[J].中国应用生理学杂志,2003,19:341-344.
[33] Chen Z,Putt DA,Lash LH.Enrichment and functional reconstitution of glutathione transport activity from rabbit kidney mitochondria:further evidence for the role of the dicarboxylate and 2-oxoglutarate carriers in mitochondrial glutathione transport [J].Arch Biochem Biophys,2000,373:193-202.