[1] WONG Y K,XU C,KALESH K A,et al.Artemisinin as an anticancer drug:recent advances in target profiling and mechanisms of action[J].Med Res Rev,2017,37(6):1492-1517.
[2] 郭宗儒.青蒿素类抗疟药的研制[J].药学学报,2016,51(1):157-164.
[3] LU J J,MENG L H,SHANKAVARAM U T,et al.Dihydroartemisinin accelerates c-MYC oncoprotein degradation and induces apoptosis in c-MYC-overexpressing tumor cells[J].Biochem Pharmacol,2010,80(1):22-30.
[4] LIANG S,SUN K,WANG Y,et al.Role of Cyt-C/caspases-9,3,Bax/Bcl-2 and the FAS death receptor pathway in apoptosis induced by zinc oxide nanoparticles in human aortic endothelial cells and the protective effect by alpha-lipoic acid[J].Chem Biol Interact,2016,258:40-51.
[5] HE Q,SHI J,SHEN X L,et al.Dihydroartemisinin upregulates death receptor 5 expression and cooperates with TRAIL to induce apoptosis in human prostate cancer cells[J].Cancer Biol Ther,2010,9(10):819-824.
[6] KONG R,JIA G,CHENG Z X,et al.Correction:dihydroartemisinin enhances Apo2L/TRAIL-mediated apoptosis in pancreatic cancer cells via ROS-mediated up-regulation of death receptor 5[J].Plos ONE,2012,7(5):e37222.
[7] LI Y W,ZHANG W,XU N,et al.Dihydroartemisinin inhibits proliferation of pancreatic cancer JF-305 cells by regulating expression of apoptosis related proteins and production of reactive oxygen species[J].Zhongguo Zhong Yao Za Zhi,2017,42(15):3026-3030.
[8] ZUO Z J,WANG S T,JIANG L X,et al.Effect of dihydroartemisinin combined irradiation on the apoptosis of human lung cancer GLC-82 cells and its mechanism study[J].Zhongguo Zhong XI Yi Jie He Za Zhi,2014,34(10):1220-1224.
[9] LU M,SUN L,ZHOU J,et al.Dihydroartemisinin-induced apoptosis is associated with inhibition of sarco/endoplasmic reticulum calcium ATPase activity in colorectal cancer[J].Cell Biochem Biophys,2015,73(1):137-145.
[10] QIN G,ZHAO C,ZHANG L,et al.Dihydroartemisinin induces apoptosis preferentially via a Bim-mediated intrinsic pathway in hepatocarcinoma cells[J].Apoptosis,2015,20(8):1072-1086.
[11] LIAO K,LI J,WANG Z.Dihydroartemisinin inhibits cell proliferation via AKT/GSK3β/cyclinD1 pathway and induces apoptosis in A549 lung cancer cells[J].Int J Clin Exp Pathol,2014,7(12):8684.
[12] FASANO E,SERINI S,PICCIONI E,et al.DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines[J].Biochim Biophys Acta,2012,1822(11):1762-1772.
[13] CHEN S S,HU W,WANG Z,et al.p8 attenuates the apoptosis induced by dihydroartemisinin in cancer cells through promoting autophagy[J].Cancer Biol Ther,2015,16(5):770-779.
[14] CHEN M,CHEN T S,LU Y Y,et al.Dihydroarteminsin-induced apoptosis is not dependent on the translocation of Bim to the endoplasmic reticulum in human lung adenocarcinoma cells[J].Pathol Oncol Res,2012,18(4):809-816.
[15] ZHANG C,SYED T W,LIU R,et al.Role of endoplasmic reticulum stress,autophagy,and inflammation in cardiovascular disease[J].Front Cardiovasc Med,2017,4:29.
[16] DU X X,LI Y J,WU C L,et al.Initiation of apoptosis,cell cycle arrest and autophagy of esophageal cancer cells by dihydroartemisinin[J].Biomed Pharmac,2013,67(5):417-424.
[17] MARCINIAK S J,RON D.Endoplasmic reticulum stress signaling in disease[J].Physiol Rev,2006,86(4):1133-1149.
[18] SCHRÖDER M.Endoplasmic reticulum stress responses[J].Cell Mol Life Sci,2008,65(6):862-894.
[19] WANG M,KAUFMAN R J.Protein misfolding in the endoplasmic reticulum as a conduit to human disease[J].Nature,2016,529(7586):326-335.
[20] HANAHAN D,WEINBERG R A.Hallmarks of cancer:the next generation[J].Cell,2011,144(5):646-674.
[21] INGHAM M,SCHWARTZ G K.Biology of neoplasia:cell-cycle therapeutics come of age[J].J Clin Oncol,2017,35(25):2949-2959.
[22] MAGENTA D,SANGIOVANNI E,BASILICO N,et al.Inhibition of metalloproteinase-9 secretion and gene expression by artemisinin derivatives[J].Acta Trop,2014,140:77-83.
[23] LIN R,ZHANG Z,CHEN L,et al.Dihydroartemisinin (DHA) induces ferroptosis and causes cell cycle arrest in head and neck carcinoma cells[J].Cancer Lett,2016,381(1):165-175.
[24] TONG Y,LIU Y,ZHENG H,et al.Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling[J].Oncotarget,2016,7(21):31413-31428.
[25] MI Y,GENG G,ZOU Z,et al.Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells[J].PloS ONE,2015,10(3):e0120426.
[26] ALASEEM A,ALHAZZANI K,Dondapati P,et al.Matrix metalloproteinases:a challenging paradigm of cancer management[J].Semin Cancer Biol,2017,Epub.
[27] SHAO Y Y,ZHANG T L,WU L X,et al.AKT Axis,miR-21,and RECK play pivotal roles in dihydroartemisinin killing malignant glioma cells[J].Int J Mol Sci,2017,18(2):350.
[28] HWANG Y P,YUN H J,KIM H G,et al.Suppression of PMA-induced tumor cell invasion by dihydroartemisinin via inhibition of PKCalpha/Raf/MAPKs and NF-kappaB/AP-1-dependent mechanisms[J].Biochem Pharmacol,2010,79(12):1714-1726.
[29] HU C J,ZHOU L,CAI Y.Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2[J].Cancer Biol Ther,2014,15(3):279-288.
[30] CHEN J,CHEN X,WANG F,et al.Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway[J].Neurol Sci,2015,36(3):435-440.
[31] WANG S J,SUN B,CHENG Z X,et al.Dihydroartemisinin inhibits angiogenesis in pancreatic cancer by targeting the NF-κB pathway[J].Cancer Chemother Pharmacol,2011,68(6):1421.
[32] PILATI P,NITTI D,MOCELLIN S.Cancer resistance to type Ⅱ topoisomerase inhibitors[J].Curr Med Chem,2012,19(23):3900-3906.
[33] WIJDEVEN R H,PANG B,ASSARAF Y G,et al.Old drugs,novel ways out:Drug resistance toward cytotoxic chemotherapeutics[J].Drug Resist Updat,2016,28:65-81.
[34] ONTIKATZE T,RUDNER J,HANDRICK R,et al.Dihydroartemisinin is a hypoxia-active anti-cancer drug in colorectal carcinoma cells[J].Front Oncol,2014,4:116.
[35] CARO J T,MARíN L M,IAZBIK M C,et al.Markers of iron metabolism in retired racing greyhounds with and without osteosarcoma[J].Vet Clin Pathol,2013,42(3):360-363.
[36] JIA L,SONG Q,ZHOU C,et al.Dihydroartemisinin as a putative STAT3 inhibitor,suppresses the growth of head and neck squamous cell carcinoma by targeting Jak2/STAT3 signaling[J].PloS ONE,2016,11(1):e0147157.
[37] CAO L,DUANMU W,YIN Y,et al.Dihydroartemisinin exhibits anti-glioma stem cell activity through inhibiting p-AKT and activating caspase-3[J].Pharmazie,2014,69(10):752-758.