[1] |
MA R, ORTIZ SERRANO T P, DAVIS J, et al. The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease[J]. Faseb J,2020,34(10):13156-13170. doi: 10.1096/fj.202001607R |
[2] |
O'NEILL L A J. Sensing the dark side of DNA[J]. Science,2013,339(6121):763-764. doi: 10.1126/science.1234724 |
[3] |
GAO D, WU J, WU Y T, et al. Cyclic GMP-AMP synthase is an innate immune sensor of HIV and other retroviruses[J]. Science,2013,341(6148):903-906. doi: 10.1126/science.1240933 |
[4] |
SWANSON K V, JUNKINS R D, KURKJIAN C J, et al. A noncanonical function of cGAMP in inflammasome priming and activation[J]. J Exp Med,2017,214(12):3611-3626. doi: 10.1084/jem.20171749 |
[5] |
COHEN D, MELAMED S, MILLMAN A, et al. Cyclic GMP-AMP signalling protects bacteria against viral infection[J]. Nature,2019,574(7780):691-695. doi: 10.1038/s41586-019-1605-5 |
[6] |
LI T, CHEN Z J. The cGAS-cGAMP-STING pathway connects DNA damage to inflammation, senescence, and cancer[J]. J Exp Med,2018,215(5):1287-1299. doi: 10.1084/jem.20180139 |
[7] |
LI W, LU L, LU J, et al. cGAS-STING-mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy[J]. Sci Transl Med,2020,12(549). doi: 10.1126/scitranslmed.aay9013 |
[8] |
SHARMA S, SCHMID M A, SANCHEZ FELIPE L, et al. Small-molecule inhibitors of TBK1 serve as an adjuvant for a plasmid-launched live-attenuated yellow fever vaccine[J]. Hum Vaccin Immunother,2020,16(9):2196-2203. doi: 10.1080/21645515.2020.1765621 |
[9] |
JIANG M, CHEN P, WANG L, et al. cGAS-STING, an important pathway in cancer immunotherapy[J]. J Hematol Oncol,2020,13(1):81. doi: 10.1186/s13045-020-00916-z |
[10] |
VOGT D, ZAVER S, RANJAN A, et al. STING is dispensable during KSHV infection of primary endothelial cells[J]. Virology,2020,540:150-159. doi: 10.1016/j.virol.2019.11.012 |
[11] |
WANG W, HU D, WU C, et al. STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection[J]. PLoS Pathog,2020,16(3):e1008335. doi: 10.1371/journal.ppat.1008335 |
[12] |
LATIF M B, RAJA R, KESSLER P M, et al. Relative contributions of the cGAS-STING and TLR3 signaling pathways to attenuation of Herpes simplex virus 1 replication[J]. J Virol,2020,94(6):e01717-e01719. |
[13] |
YOU H J, LIN Y Y, LIN F, et al. Β-catenin is required for the cGAS/STING signaling pathway but antagonized by the Herpes simplex virus 1 US3 protein[J]. J Virol,2019,94(5):1-13. |
[14] |
LI D, WU R, GUO W, et al. STING-mediated IFI16 degradation negatively controls type I interferon production[J]. Cell Rep,2019,29(5):1249-1260.e4. doi: 10.1016/j.celrep.2019.09.069 |
[15] |
ZHOU C, CHEN X, PLANELLS-CASES R, et al. Transfer of cGAMP into bystander cells via LRRC8 volume-regulated anion channels augments STING-mediated interferon responses and anti-viral immunity[J]. Immunity,2020,52(5):767-781.e6. doi: 10.1016/j.immuni.2020.03.016 |
[16] |
LEE J K, KIM J E, PARK B J, et al. Human Cytomegalovirus IE86 protein aa 136-289 mediates STING degradation and blocks the cGAS-STING pathway[J]. J Microbiol,2020,58(1):54-60. doi: 10.1007/s12275-020-9577-6 |
[17] |
LIO C W, MCDONALD B, TAKAHASHI M, et al. cGAS-STING signaling regulates initial innate control of Cytomegalovirus infection[J]. J Virol,2016,90(17):7789-7797. doi: 10.1128/JVI.01040-16 |
[18] |
WANG J, WANG C F, MING S L, et al. Porcine IFITM1 is a host restriction factor that inhibits pseudorabies virus infection[J]. Int J Biol Macromol,2020,151:1181-1193. doi: 10.1016/j.ijbiomac.2019.10.162 |
[19] |
CHENG W Y, HE X B, JIA H J, et al. The cGas-sting signaling pathway is required for the innate immune response against ectromelia virus[J]. Front Immunol,2018,9:1297. doi: 10.3389/fimmu.2018.01297 |
[20] |
ITO H, KANBE A, HARA A, et al. Induction of humoral and cellular immune response to HBV vaccine can be up-regulated by STING ligand[J]. Virology,2019,531:233-239. doi: 10.1016/j.virol.2019.03.013 |
[21] |
PÉPIN G, DE NARDO D, ROOTES C L, et al. Connexin-dependent transfer of cGAMP to phagocytes modulates antiviral responses[J]. mBio,2020,11(1). doi: 10.1128/mbio.03187-19 |
[22] |
WANG C, GUAN Y, LV M, et al. Manganese increases the sensitivity of the cGAS-STING pathway for double-stranded DNA and is required for the host defense against DNA viruses[J]. Immunity,2018,48(4):675-687.e7. doi: 10.1016/j.immuni.2018.03.017 |
[23] |
SU C I, KAO Y T, CHANG C C, et al. DNA-induced 2'3'-cGAMP enhances haplotype-specific human STING cleavage by dengue protease[J]. PNAS,2020,117(27):15947-15954. doi: 10.1073/pnas.1922243117 |
[24] |
GUTJAHR A, PAPAGNO L, NICOLI F, et al. The STING ligand cGAMP potentiates the efficacy of vaccine-induced CD8+T cells[J]. JCI Insight,2019,4(7). doi: 10.1172/jci.insight.125107 |
[25] |
HOU S, LAN X J, LI W, et al. Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonists[J]. Bioorg Chem,2020,95:103556. doi: 10.1016/j.bioorg.2019.103556 |
[26] |
ZHANG X, LIU B, TANG L, et al. Discovery and mechanistic study of a novel human-Stimulator-of-interferon-genes agonist[J]. ACS Infect Dis,2019,5(7):1139-1149. doi: 10.1021/acsinfecdis.9b00010 |
[27] |
LIAN H, WEI J, ZANG R, et al. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response[J]. Nat Commun,2018,9(1):3349. doi: 10.1038/s41467-018-05559-w |
[28] |
KU J W K, CHEN Y, LIM B J W, et al. Bacterial-induced cell fusion is a danger signal triggering cGAS-STING pathway via micronuclei formation[J]. PNAS,2020,117(27):15923-15934. doi: 10.1073/pnas.2006908117 |
[29] |
PALERMO E, ACCHIONI C, DI CARLO D, et al. Activation of latent HIV-1 T cell reservoirs with a combination of innate immune and epigenetic regulators[J]. J Virol,2019,93(21). doi: 10.1128/jvi.01194-19 |
[30] |
DEWI PAMUNGKAS PUTRI D, KAWASAKI T, MURASE M, et al. PtdIns3P phosphatases MTMR3 and MTMR4 negatively regulate innate immune responses to DNA through modulating STING trafficking[J]. J Biol Chem,2019,294(21):8412-8423. doi: 10.1074/jbc.RA118.005731 |
[31] |
GHOSH A, SHAO L, SAMPATH P, et al. Oligoadenylate-synthetase-family protein OASL inhibits activity of the DNA sensor cGAS during DNA virus infection to limit interferon production[J]. Immunity,2019,50(1):51-63.e5. doi: 10.1016/j.immuni.2018.12.013 |
[32] |
GONG T, LIU L, JIANG W, et al. DAMP-sensing receptors in sterile inflammation and inflammatory diseases[J]. Nat Rev Immunol,2020,20(2):95-112. doi: 10.1038/s41577-019-0215-7 |
[33] |
HUANG Z F, ZOU H M, LIAO B W, et al. Human Cytomegalovirus protein UL31 inhibits DNA sensing of cGAS to mediate immune evasion[J]. Cell Host Microbe,2018,24(1):69-80.e4. doi: 10.1016/j.chom.2018.05.007 |
[34] |
FU Y Z, GUO Y, ZOU H M, et al. Human Cytomegalovirus protein UL42 antagonizes cGAS/MITA-mediated innate antiviral response[J]. PLoS Pathog,2019,15(5):e1007691. doi: 10.1371/journal.ppat.1007691 |