[1] THI T H, Nguyen, . Improving silymarin oral bioavailability using silica-installed redox nanoparticle to suppress inflammatory bowel disease[J]. J Control Release, 2021, 331: 515-524. doi:  10.1016/j.jconrel.2020.10.042
[2] OMMATI M M, FARSHAD O, AZARPIRA N, et al. Silymarin mitigates bile duct obstruction-induced cholemic nephropathy[J]. Naunyn-Schmiedeberg’s Arch Pharmacol, 2021, 394(6): 1301-1314. doi:  10.1007/s00210-020-02040-8
[3] ZENG Q P, LIU Z H, HUANG A W, et al. Preparation and characterization of silymarin synchronized-release microporous osmotic pump tablets[J]. Drug Des Devel Ther, 2016, 10: 519-531.
[4] MASTRON J K, SIVEEN K S, SETHI G, et al. Silymarin and hepatocellular carcinoma: a systematic, comprehensive, and critical review[J]. Anticancer Drugs, 2015, 26(5): 475-486. doi:  10.1097/CAD.0000000000000211
[5] KIM S H, CHOO G S, YOO E S, et al. Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells[J]. Oncol Rep, 2019, 42(5): 1904-1914.
[6] KUMAR J, PARK K C, AWASTHI A, et al. Silymarin extends lifespan and reduces proteotoxicity in C. elegans Alzheimer’s model[J]. CNS Neurol Disord Drug Targets, 2015, 14(2): 295-302. doi:  10.2174/1871527314666150116110212
[7] ATAIHIRE J U, NWANGWA E K, IGWEH J C. Modulations in anti-oxidant activities of selected gastro-intestinal tissues in alloxan-induced, silymarin treated diabetic wistar rats[J]. OJGas, 2019, 9(5): 73-90. doi:  10.4236/ojgas.2019.95010
[8] TVRDÝ V, POUROVÁ J, JIRKOVSKÝ E, et al. Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin[J]. Med Res Rev, 2021, 41(4): 2195-2246. doi:  10.1002/med.21791
[9] 袁晓炫, 要辉, 张欣, 等. 天麻素微孔渗透泵缓释片的制备及其药动学评价[J]. 中国医院药学杂志, 2021, 41(17): 1742-1748.
[10] 王玉华, 杨海燕, 郝海军. 环维黄杨星D包合物微孔渗透泵控释片的制备及处方优化[J]. 中成药, 2020, 42(10): 2555-2560.
[11] 国家药典委员会. 中国药典2015年版四部[S]. 北京: 中国医药科技出版社, 2015: 121-124.
[12] ZHU H J, BRINDA B J, CHAVIN K D, et al. An assessment of pharmacokinetics and antioxidant activity of free silymarin flavonolignans in healthy volunteers: a dose escalation study[J]. Drug Metab Dispos, 2013, 41(9): 1679-1685. doi:  10.1124/dmd.113.052423
[13] 王迪, 俞佳, 詹固, 等. 液质联用技术在中药研究中的应用进展[J]. 中华中医药学刊, 2022, 40(2): 68-71.
[14] 李秉新, 王鑫, 刘有平, 等. 水飞蓟宾非对映异构体在大鼠肝微粒体中葡萄糖醛酸化代谢的酶动力学比较研究[J]. 沈阳药科大学学报, 2018, 35(4): 289-294, 305.
[15] 肖衍宇, 宋赟梅, 陈志鹏, 等. 水飞蓟素前体脂质体的制备和大鼠药代动力学的研究[J]. 药学学报, 2005, 40(8): 758-763.
[16] 周旖璇, 张纯刚, 尹丽, 等. 水飞蓟宾原料药、利加隆、水林佳大鼠体内药物动力学研究[J]. 亚太传统医药, 2021, 17(6): 11-15.