离子导入给药的研究进展

蒋薇薇; 杨峰; 蒋薇薇; 杨峰

doi:10.12206/j.issn.2097-2024.202208008

[1]

KARPIŃSKI T M. Selected medicines used in iontophoresis[J]. Pharmaceutics,2018,10(4):204. doi: 10.3390/pharmaceutics10040204

[2]

LIATSOPOULOU A, VARVARESOU A, MELLOU F, et al. Iontophoresis in dermal delivery: a review of applications in dermato-cosmetic and aesthetic sciences[J]. Int J Cosmet Sci, 2023: ICS-2022.

[3]

TARI K, KHAMOUSHIAN S, MADRAKIAN T, et al. Controlled transdermal iontophoresis of insulin from water-soluble polypyrrole nanoparticles: an in vitro study[J]. Int J Mol Sci,2021,22(22):12479. doi: 10.3390/ijms222212479

[4]

PEREZ V, WIROSTKO B, KORENFELD M, et al. Ophthalmic drug delivery using iontophoresis: recent clinical applications[J]. J Ocul Pharmacol Ther,2020,36(2):75-87.

[5]

HASAN M, KHATUN A, KOGURE K. Iontophoresis of biological macromolecular drugs[J]. Pharmaceutics,2022,14(3):525. doi: 10.3390/pharmaceutics14030525

[6]

OBERLI M A, SCHOELLHAMMER C M, LANGER R, et al. Ultrasound-enhanced transdermal delivery: recent advances and future challenges[J]. Ther Deliv,2014,5(7):843-857. doi: 10.4155/tde.14.32

[7]

KANG D, GE Q, NATABOU M A, et al. Bolus delivery of palonosetron through skin by tip-loaded dissolving microneedles with short-duration iontophoresis: a potential strategy to rapidly relieve emesis associated with chemotherapy[J]. Int J Pharm,2022,628:122294. doi: 10.1016/j.ijpharm.2022.122294

[8]

PHATALE V, VAIPHEI K K, JHA S, et al. Overcoming skin barriers through advanced transdermal drug delivery approaches[J]. J Control Release,2022,351:361-380. doi: 10.1016/j.jconrel.2022.09.025

[9]

SHENG T, LUO B, ZHANG W, et al. Microneedle-mediated vaccination: innovation and translation[J]. Adv Drug Deliv Rev,2021,179:113919. doi: 10.1016/j.addr.2021.113919

[10]

HAN H S, HONG J Y, KWON T R, et al. Mechanism and clinical applications of needle-free injectors in dermatology: literature review[J]. J Cosmet Dermatol,2021,20(12):3793-3801. doi: 10.1111/jocd.14047

[11]

ELJARRAT-BINSTOCK E, BENTOLILA A, KUMAR N, et al. Preparation, characterization, and sterilization of hydrogel sponges for iontophoretic drug-delivery use[J]. Polym Adv Technol,2007,18(9):720-730. doi: 10.1002/pat.948

[12]

ROUSTIT M, BLAISE S, CRACOWSKI J L. Trials and tribulations of skin iontophoresis in therapeutics[J]. Br J Clin Pharmacol,2014,77(1):63-71. doi: 10.1111/bcp.12128

[13]

龚英彪, 江昌照, 张琪, 等. 离子电渗给药技术研究进展[J]. 中国现代应用药学, 2020, 37(11):1402-1408. doi: 10.13748/j.cnki.issn1007-7693.2020.11.023

[14]

WANG Y, ZENG L J, SONG W T, et al. Influencing factors and drug application of iontophoresis in transdermal drug delivery: an overview of recent progress[J]. Drug Deliv and Transl Res,2022,12(1):15-26. doi: 10.1007/s13346-021-00898-6

[15]

ZUO J, DU L, LI M, et al. Transdermal enhancement effect and mechanism of iontophoresis for non-steroidal anti-inflammatory drugs[J]. Int J Pharm,2014,466(1-2):76-82. doi: 10.1016/j.ijpharm.2014.03.013

[16]

AKHTAR N, SINGH V, YUSUF M, et al. Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications[J]. Biomed Tech (Berl),2020,65(3):243-272. doi: 10.1515/bmt-2019-0019

[17]

HASAN M, KHATUN A, FUKUTA T, et al. Noninvasive transdermal delivery of liposomes by weak electric current[J]. Adv Drug Deliv Rev,2020,154-155:227-235. doi: 10.1016/j.addr.2020.06.016

[18]

BLAISE S, ROUSTIT M, HELLMANN M, et al. Cathodal iontophoresis of treprostinil induces a sustained increase in cutaneous blood flux in healthy volunteers[J]. J Clin Pharmacol,2013,53(1):58-66. doi: 10.1177/0091270011434352

[19]

YAN C, NG J N C, WANITPHAKDEEDECHA R. Efficacy of handheld iontophoresis device in enhancing transdermal vitamin C delivery: a split-face clinical trial[J]. J Cosmet Dermatol,2022,21(2):698-706. doi: 10.1111/jocd.14702

[20]

MANGNUS T J P, BHARWANI K D, STRONKS D L, et al. Ketamine therapy for chronic pain in The Netherlands: a nationwide survey[J]. Scand J Pain,2021,22(1):97-105. doi: 10.1016/j.jpain.2020.06.005

[21]

王争, 梁亮, 陈玢琳. 水凝胶作为眼部药物控释系统载体的研究进展[J]. 巴楚医学, 2021, 4(1):115-119. doi: 10.3969/j.issn.2096-6113.2021.01.026

[22]

AN Y H, LEE J, SON D U, et al. Facilitated transdermal drug delivery using nanocarriers-embedded electroconductive hydrogel coupled with reverse electrodialysis-driven iontophoresis[J]. ACS Nano,2020,14(4):4523-4535. doi: 10.1021/acsnano.0c00007

[23]

ZHAO F, FAN S, GHATE D, et al. A hydrogel ionic circuit based high-intensity iontophoresis device for intraocular macromolecule and nanoparticle delivery[J]. Adv Mater,2022,34(5):2107315. doi: 10.1002/adma.202107315

[24]

AKEL F, Kanaan,. Semi-interpenetrating chitosan/ionic liquid polymer networks as electro-responsive biomaterials for potential wound dressings and iontophoretic applications[J]. Mater Sci Eng C,2021,121:111798. doi: 10.1016/j.msec.2020.111798

[25]

TYAGI V, DEL RIO-SANCHO S, LAPTEVA M, et al. Topical iontophoresis of buflomedil hydrochloride increases drug bioavailability in the mucosa: a targeted approach to treat oral submucous fibrosis[J]. Int J Pharm,2019,569:118610. doi: 10.1016/j.ijpharm.2019.118610

[26]

GUIGUI A, MAZET R, BLAISE S, et al. Treprostinil hydrogel iontophoresis in systemic sclerosis-related digital skin ulcers: a safety study[J]. J Clin Pharmacol,2020,60(6):758-767. doi: 10.1002/jcph.1574

[27]

GRATIERI T, SANTER V, KALIA Y N. Basic principles and current status of transcorneal and transscleral iontophoresis[J]. Expert Opin Drug Deliv,2017,14(9):1091-1102. doi: 10.1080/17425247.2017.1266334

[28]

郝佳旭, 范晓, 查丽春, 等. 微针经皮给药系统及应用研究进展[J]. 辽宁中医药大学学报, 2022, 24(5):100-107. doi: 10.13194/j.issn.1673-842x.2022.05.021

[29]

VORA D, GARIMELLA H T, GERMAN C L, et al. Microneedle and iontophoresis mediated delivery of methotrexate into and across healthy and psoriatic skin[J]. Int J Pharm,2022,618:121693. doi: 10.1016/j.ijpharm.2022.121693

[30]

XIAO S, YAN Y, ZHAO J, et al. Increased microneedle-mediated transdermal delivery of tetramethylpyrazine to the brain, combined with borneol and iontophoresis, for MCAO prevention[J]. Int J Pharm,2020,575:118962. doi: 10.1016/j.ijpharm.2019.118962

[31]

KALE M, KIPPING T, BANGA A K. Modulated delivery of donepezil using a combination of skin microporation and iontophoresis[J]. Int J Pharm,2020,589:119853. doi: 10.1016/j.ijpharm.2020.119853

[32]

DANDEKAR A A, GARIMELLA H T, GERMAN C L, et al. Microneedle mediated iontophoretic delivery of tofacitinib citrate[J]. Pharm Res, 2022: 1-13.

[33]

GUJJAR M, BANGA A K. Iontophoretic and microneedle mediated transdermal delivery of glycopyrrolate[J]. Pharmaceutics,2014,6(4):663-671. doi: 10.3390/pharmaceutics6040663

[34]

PAUL J, Ronnander,. Transdermal delivery of sumatriptan succinate using iontophoresis and dissolving microneedles[J]. J Pharm Sci,2019,108(11):3649-3656. doi: 10.1016/j.xphs.2019.07.020

[35]

ABBASI M, FAN Z, DAWSON J A, et al. Transdermal delivery of metformin using dissolving microneedles and iontophoresis patches for browning subcutaneous adipose tissue[J]. Pharmaceutics,2022,14(4):879. doi: 10.3390/pharmaceutics14040879

[36]

GUY R H, KALIA Y N, DELGADO-CHARRO M B, et al. Iontophoresis: electrorepulsion and electroosmosis[J]. J Control Release,2000,64(1-3):129-132. doi: 10.1016/S0168-3659(99)00132-7

[37]

NOH G, KEUM T, SEO J E, et al. Iontophoretic transdermal delivery of human growth hormone (hGH) and the combination effect of a new type microneedle, tappy Tok tok^®[J]. Pharmaceutics,2018,10(3):153. doi: 10.3390/pharmaceutics10030153

[38]

BOK M, ZHAO Z J, JEON S, et al. Ultrasonically and iontophoretically enhanced drug-delivery system based on dissolving microneedle patches[J]. Sci Rep,2020,10(1):2027. doi: 10.1038/s41598-020-58822-w

[39]

KUSAMA S, SATO K, MATSUI Y, et al. Transdermal electroosmotic flow generated by a porous microneedle array patch[J]. Nat Commun,2021,12(1):658. doi: 10.1038/s41467-021-20948-4

[40]

BAI Y, SACHDEVA V, KIM H, et al. Transdermal delivery of proteins using a combination of iontophoresis and microporation[J]. Ther Deliv,2014,5(5):525-536. doi: 10.4155/tde.14.19

[41]

LI X L, HUANG X S, MO J S, et al. A fully integrated closed-loop system based on mesoporous microneedles-iontophoresis for diabetes treatment[J]. Adv Sci,2021,8(16):2100827. doi: 10.1002/advs.202100827

[42]

YANG J B, LI Y J, YE R, et al. Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery[J]. Microsyst Nanoeng,2020,6:112. doi: 10.1038/s41378-020-00224-z

[43]

YU Y Q, YANG X, WU X F, et al. Enhancing permeation of drug molecules across the skin via delivery in nanocarriers: novel strategies for effective transdermal applications[J]. Front Bioeng Biotechnol,2021,9:646554. doi: 10.3389/fbioe.2021.646554

[44]

MALINOVSKAJA-GOMEZ K, LABOUTA H I, SCHNEIDER M, et al. Transdermal iontophoresis of flufenamic acid loaded PLGA nanoparticles[J]. Eur J Pharm Sci,2016,89:154-162. doi: 10.1016/j.ejps.2016.04.034

[45]

CHAROENPUTTAKUN P, LI S K, NGAWHIRUNPAT T. Iontophoretic delivery of lipophilic and hydrophilic drugs from lipid nanoparticles across human skin[J]. Int J Pharm,2015,495(1):318-328. doi: 10.1016/j.ijpharm.2015.08.094

[46]

HASAN M, FUKUTA T, INOUE S, et al. Iontophoresis-mediated direct delivery of nucleic acid therapeutics, without use of carriers, to internal organs via non-blood circulatory path-ways[J]. J Control Release,2022,343:392-399. doi: 10.1016/j.jconrel.2022.01.052

[47]

KAZEMI M, MOMBEINY R, TAVAKOL S, et al. A combination therapy of nanoethosomal piroxicam formulation along with iontophoresis as an anti-inflammatory transdermal delivery system for wound healing[J]. Int Wound J,2019,16(5):1144-1152. doi: 10.1111/iwj.13171

[48]

MOMBEINY R, TAVAKOL S, KAZEMI M, et al. Anti-inflammatory ethosomal nanoformulation in combination with iontophoresis in chronic wound healing: an ex vivo study[J]. IET Nanobiotechnology,2021,15(9):710-718. doi: 10.1049/nbt2.12069

[49]

BRENO N, Matos,. Chitosan nanoparticles loading oxaliplatin as a mucoadhesive topical treatment of oral tumors: Iontophoresis further enhances drug delivery ex vivo[J]. Int J Biol Macromol,2020,154:1265-1275. doi: 10.1016/j.ijbiomac.2019.11.001

[50]

ALVI S B, RAJALAKSHMI P S, JOGDAND A, et al. Iontophoresis mediated localized delivery of liposomal gold nanoparticles for photothermal and photodynamic therapy of acne[J]. Biomater Sci,2021,9(4):1421-1430. doi: 10.1039/D0BM01712D

[51]

DHAL S, PAL K, GIRI S. Transdermal delivery of gold nanoparticles by a soybean oil-based oleogel under iontophoresis[J]. ACS Appl Bio Mater,2020,3(10):7029-7039. doi: 10.1021/acsabm.0c00893

[52]

LABALA S, JOSE A, CHAWLA S R, et al. Effective melanoma cancer suppression by iontophoretic co-delivery of STAT3 siRNA and imatinib using gold nanoparticles[J]. Int J Pharm,2017,525(2):407-417. doi: 10.1016/j.ijpharm.2017.03.087

[53]

TAVEIRA S F, DE SANTANA D C A S, ARAÚJO L M P C, et al. Effect of iontophoresis on topical delivery of doxorubicin-loaded solid lipid nanoparticles[J]. J Biomed Nanotechnol,2014,10(7):1382-1390. doi: 10.1166/jbn.2014.1834

[54]

PEDROZA R B, Moura, Ms, et al. Combination of lipid nanoparticles and iontophoresis for enhanced lopinavir skin permeation: impact of electric current on lipid dynamics[J]. Eur J Pharm Sci,2022,168:106048. doi: 10.1016/j.ejps.2021.106048

[55]

NGUYEN H X, BANGA A K. Electrically and ultrasonically enhanced transdermal delivery of methotrexate[J]. Pharmaceutics,2018,10(3):117. doi: 10.3390/pharmaceutics10030117

[56]

VAIDYA J, SHENDE P. Potential of sonophoresis as a skin penetration technique in the treatment of rheumatoid arthritis with transdermal patch[J]. AAPS Pharmscitech,2020,21(5):180. doi: 10.1208/s12249-020-01725-w

[57]

PARK J, LEE H, LIM G S, et al. Enhanced transdermal drug delivery by sonophoresis and simultaneous application of sonophoresis and iontophoresis[J]. AAPS Pharmscitech,2019,20(3):96. doi: 10.1208/s12249-019-1309-z

[58]

杜丽娜, 金义光. 经皮给药系统研究进展[J]. 国际药学研究杂志, 2013, 40(4):379-385. doi: 10.13220/j.cnki.jipr.2013.04.002

[59]

TEAIMA M H, MOHAMED M A A, ABD EL REHEM R T, et al. Enhanced transdermal delivery of bisoprolol hemifumarate via combined effect of iontophoresis and chemical enhancers: ex vivo permeation/in vivo pharmacokinetic studies[J]. Pharmaceutics,2021,13(5):682. doi: 10.3390/pharmaceutics13050682