蛋白质结晶的新进展与药物设计

陈维敬; 仲维清

doi:10.3969/j.issn.1006-0111.2012.02.001

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蛋白质结晶的新进展与药物设计

陈维敬, 仲维清

文章导航 > 药学实践与服务 > 2012 > 30(2): 81-85,136

陈维敬, 仲维清. 蛋白质结晶的新进展与药物设计[J]. 药学实践与服务, 2012, 30(2): 81-85,136. doi: 10.3969/j.issn.1006-0111.2012.02.001

引用本文:

陈维敬, 仲维清. 蛋白质结晶的新进展与药物设计[J]. 药学实践与服务, 2012, 30(2): 81-85,136. doi: 10.3969/j.issn.1006-0111.2012.02.001

CHEN Wei-jing, ZHONG Wei-qing. New progress of protein crystallization and drug design[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 81-85,136. doi: 10.3969/j.issn.1006-0111.2012.02.001

Citation:

CHEN Wei-jing, ZHONG Wei-qing. New progress of protein crystallization and drug design[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 81-85,136. doi: 10.3969/j.issn.1006-0111.2012.02.001

蛋白质结晶的新进展与药物设计

doi: 10.3969/j.issn.1006-0111.2012.02.001

第二军医大学药学院无机化学教研室, 上海 200433

基金项目: 国家自然科学基金资助项目(20371050).

New progress of protein crystallization and drug design

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 蛋白质是生命的基础,其功能与它的三维结构密切相关,关于蛋白质的结构信息,对科学家根据结构同源性确定药物靶标以及发现新的药物靶标等方面均有至关重要的作用。因此,蛋白质晶体的获得及其与药物设计的关系日益受到重视,已成为生命科学中的一个重要领域,本文主要综述了蛋白质结晶技术的最新研究进展以及在药物设计中的应用。
- 蛋白质 /
- 晶体 /
- 靶点 /
- 药物设计
Abstract: Protein was the foundation of all life, and its function was closely related to its three-dimensional structure. The structure information of proteins was crucial for the determination of drug targets and helped scientists to discover new drug targets according to the structure homology between the protein targets and drugs. Therefore, the availability of protein crystal, which was the basis for its structure information and the drug design, had become an important field in life science. The latest research progresses of protein crystallization technology and its application in the drug design were summarized in this review.
- protein /
- crystallization /
- target /
- drug design

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蛋白质结晶的新进展与药物设计

doi: 10.3969/j.issn.1006-0111.2012.02.001

第二军医大学药学院无机化学教研室, 上海 200433

基金项目: 国家自然科学基金资助项目(20371050).

收稿日期: 2010-07-22
修回日期: 2011-07-11

关键词:

蛋白质 /

晶体 /

靶点 /

药物设计

摘要: 蛋白质是生命的基础,其功能与它的三维结构密切相关,关于蛋白质的结构信息,对科学家根据结构同源性确定药物靶标以及发现新的药物靶标等方面均有至关重要的作用。因此,蛋白质晶体的获得及其与药物设计的关系日益受到重视,已成为生命科学中的一个重要领域,本文主要综述了蛋白质结晶技术的最新研究进展以及在药物设计中的应用。