[1] BANI MM, MAJDI SA. Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH[J]. Asian Pac J Cancer Prev, 2017, 18(1):17-21.
[2] SIRMANS S M, PATE K A. Epidemiology, diagnosis, and management of polycystic ovary syndrome[J]. Clin Epidemiol, 2013, 6:1-13.
[3] ESCOBAR-MORREALE H F. Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment[J]. Nat Rev Endocrinol, 2018, 14(5):270-284. doi:  10.1038/nrendo.2018.24
[4] 何文艳, 师静, 周倩. 补肾活血汤治疗多囊卵巢综合征致不孕症临床研究[J]. 现代中医药, 2022, 42(3):139-142. doi:  10.13424/j.cnki.mtcm.2022.03.029
[5]

CROSBIE E J, ROBERTS C, QIAN W D, et al. Body mass index does not influence post-treatment survival in early stage endometrial cancer: results from the MRC ASTEC trial[J]. Eur J Cancer, 2012, 48(6):853-864. doi:  10.1016/j.ejca.2011.10.003
[6]

ALVAREZ-BLASCO F, BOTELLA-CARRETERO J I, SAN MILLÁN J L, et al. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women[J]. Arch Intern Med, 2006, 166(19):2081-2086. doi:  10.1001/archinte.166.19.2081
[7]

AZZIZ R, WOODS K S, REYNA R, et al. The prevalence and features of the polycystic ovary syndrome in an unselected population[J]. J Clin Endocrinol Metab, 2004, 89(6):2745-2749. doi:  10.1210/jc.2003-032046
[8]

DIAMANTI-KANDARAKIS E. Role of obesity and adiposity in polycystic ovary syndrome[J]. Int J Obes (Lond), 2007, 31 (Suppl) 2: S8-S13,discussion S31-S32.
[9]

KATAOKA J, TASSONE E C, MISSO M, et al. Weight management interventions in women with and without PCOS: a systematic review[J]. Nutrients, 2017, 9(9):996. doi:  10.3390/nu9090996
[10]

PATEL S M, NESTLER J E. Fertility in polycystic ovary syndrome[J]. Endocrinol Metab Clin North Am, 2006, 35(1):137-155. doi:  10.1016/j.ecl.2005.09.005
[11]

BADSHAH S L, ULLAH A, AHMAD N, et al. Increasing the strength and production of artemisinin and its derivatives[J]. Molecules, 2018, 23(1):100. doi:  10.3390/molecules23010100
[12]

ZYAD A, TILAOUI M, JAAFARI M, et al. More insights into the pharmacological effects of artemisinin[J]. Phytother Res, 2018, 32(2):216-229. doi:  10.1002/ptr.5958
[13]

LÜ P, ZHANG F C, QIAN S W, et al. Artemisinin derivatives prevent obesity by inducing browning of WAT and enhancing BAT function[J]. Cell Res, 2016, 26(10):1169-1172. doi:  10.1038/cr.2016.108
[14]

LEE J S, KIM M H, LEE J H, et al. Artemisinic acid is a regulator of adipocyte differentiation and C/EBP δ expression[J]. J Cellular Biochem, 2012, 113:2488-2499. doi:  10.1002/jcb.24124
[15]

JANG B C. Artesunate inhibits adipogeneis in 3T3-L1 preadipocytes by reducing the expression and/or phosphorylation levels of C/EBP-α, PPAR-γ, FAS, perilipin A, and STAT-3[J]. Biochem Biophys Res Commun, 2016, 474(1):220-225. doi:  10.1016/j.bbrc.2016.04.109
[16]

KIM S, CHEN J, CHENG T, et al. PubChem in 2021: new data content and improved web interfaces[J]. Nucleic Acids Res, 2021, 49(D1):D1388-D1395. doi:  10.1093/nar/gkaa971
[17]

GFELLER D, GROSDIDIER A, WIRTH M, et al. SwissTargetPrediction: a web server for target prediction of bioactive small molecules[J]. Nucleic Acids Res, 2014, 42(Web Server issue): W32-38.
[18]

WANG X, SHEN Y H, WANG S W, et al. PharmMapper 2017 update: a web server for potential drug target identification with a comprehensive target pharmacophore database[J]. Nucleic Acids Res, 2017, 45(W1):W356-W360. doi:  10.1093/nar/gkx374
[19]

UniProt C. UniProt: the universal protein knowledgebase in 2021[J]. Nucleic Acids Res, 2021, 49(D1):D480-D489. doi:  10.1093/nar/gkaa1100
[20]

PIÑERO J, QUERALT-ROSINACH N, BRAVO A, et al. DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes[DB]. Database (Oxford), 2015, 2015: bav028.
[21]

STELZER G, ROSEN N, PLASCHKES I, et al. The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses[J]. Curr Protoc Bioinformatics, 2016 , 54:1.30.1-1.30.33.
[22]

SZKLARCZYK D, GABLE A L, NASTOU K C, et al. The STRING database in 2021: customizable protein-protein networks, and functional characterization of user-uploaded gene/measurement sets[J]. Nucleic Acids Res, 2021, 49(D1):D605-D612. doi:  10.1093/nar/gkaa1074
[23]

OTASEK D, MORRIS J H, BOUÇAS J, et al. Cytoscape automation: empowering workflow-based network analysis[J]. Genome Biol, 2019, 20(1):185. doi:  10.1186/s13059-019-1758-4
[24]

SHERMAN B T, HAO M, QIU J, et al. DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)[J]. Nucleic Acids Res, 2022, 50(W1):W216-W221. doi:  10.1093/nar/gkac194
[25]

BURLEY S K, BHIKADIYA C, BI C, et al. RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences[J]. Nucleic Acids Res, 2021, 49(D1):D437-D451. doi:  10.1093/nar/gkaa1038
[26]

SEELIGER D, DE GROOT B L. Ligand docking and binding site analysis with PyMOL and Autodock/Vina[J]. J Comput Aided Mol Des, 2010, 24(5):417-422. doi:  10.1007/s10822-010-9352-6
[27]

GOODSELL D S, SANNER M F, OLSON A J, et al. The AutoDock suite at 30[J]. Protein Sci, 2021, 30(1):31-43. doi:  10.1002/pro.3934
[28]

LI Y, CHEN C Y, MA Y, et al. Multi-system reproductive metabolic disorder: significance for the pathogenesis and therapy of polycystic ovary syndrome (PCOS)[J]. Life Sci, 2019, 228:167-175. doi:  10.1016/j.lfs.2019.04.046
[29]

NEKOONAM S, NAJI M, NASHTAEI M S, et al. Expression of AKT1 along with AKT2 in granulosa-lutein cells of hyperandrogenic PCOS patients[J]. Arch Gynecol Obstet, 2017, 295(4):1041-1050. doi:  10.1007/s00404-017-4317-9
[30]

SONG N J, CHANG S H, KIM S, et al. PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice[J]. Cell Death Dis, 2018, 9(9):876. doi:  10.1038/s41419-018-0904-3
[31]

SYLUS A M, NANDEESHA H, CHITRA T. Matrix metalloproteinase-9 increases and Interleukin-10 reduces with increase in body mass index in polycystic ovary syndrome: A cross-sectional study[J]. Int J Reprod Biomed, 2020, 18(8):605-610.
[32]

PUTTABYATAPPA M, IRWIN A, MARTIN J D, et al. Developmental programming: gestational exposure to excess testosterone alters expression of ovarian matrix metalloproteases and their target proteins[J]. Reprod Sci, 2018, 25(6):882-892. doi:  10.1177/1933719117697127
[33]

BARBARA G, FILIP A D, JANUSZ S, et al. The association between serum metalloproteinase concentration, obesity, and hormone levels in reproductive-aged women[J]. Endokrynol Pol, 2019, 70(1):49-56. doi:  10.5603/EP.a2018.0067
[34]

TANG Z R, ZHANG R, LIAN Z X, et al. Estrogen-Receptor expression and function in female reproductive disease[J]. Cells, 2019, 8(10):1123. doi:  10.3390/cells8101123
[35]

SILVA F S, SÓTER M O, SALES M F, et al. Estrogen receptor αlpha gene (ESR1) PvuII and XbaI polymorphisms are associated to metabolic and proinflammatory factors in polycystic ovary syndrome[J]. Gene, 2015, 560(1):44-49. doi:  10.1016/j.gene.2015.01.037
[36]

SCHOMBERG D W, COUSE J F, MUKHERJEE A. Targeted disruption of the estrogen receptor-alpha gene in female mice: characterization of ovarian responses and phenotype in the adult[J]. Endocrinology, 1999, 140(6):2733-2744. doi:  10.1210/endo.140.6.6823
[37]

ARTIMANI T, SAIDIJAM M, AFLATOONIAN R. Estrogen and progesterone receptor subtype expression in granulosa cells from women with polycystic ovary syndrome[J]. Gynecol Endocrinol, 2015, 31(5):379-383. doi:  10.3109/09513590.2014.1001733
[38]

ZHOU Z Q, TIMOTHY M M, BRIAN G D, et al. Estrogen receptor α controls metabolism in white and brown adipocytes by regulating Polg1 and mitochondrial remodeling[J]. Sci Transl Med, 2020, 12(555):eaax8096. doi:  10.1126/scitranslmed.aax8096
[39]

CHEN J Y, WUY P, LI C Y, et al. PPARγ activation improves the microenvironment of perivascular adipose tissue and attenuates aortic stiffening in obesity[J]. J Biomed Sci, 2021, 28(1):22. doi:  10.1186/s12929-021-00720-y
[40]

HE Y, WANG C L. Effects of testosterone on PPARγ and P450arom expression in polycystic ovary syndrome patients and related mechanisms[J]. Eur Rev Med Pharmacol Sci, 2018, 22(6):1549-1553.
[41]

LEE J Y, TAE J C, KIM C H. Expression of the genes for peroxisome proliferator-activated receptor-γ, cyclooxygenase-2, and proinflammatory cytokines in granulosa cells from women with polycystic ovary syndrome[J]. Clin Exp Reprod Med, 2017, 44(3):146-151. doi:  10.5653/cerm.2017.44.3.146
[42] 胡卫红, 陈琳, 同军, 等. PPARγ mRNA在卵巢颗粒细胞的表达调节及与多囊卵巢综合征的相关性[J]. 北京大学学报 (医学版), 2013, 45(6):859-863.
[43]

GONG Y, LUO S, FAN P, et al. Growth hormone activates PI3K/Akt signaling and inhibits ROS accumulation and apoptosis in granulosa cells of patients with polycystic ovary syndrome[J]. Reprod Biol Endocrinol, 2020, 18(1):121. doi:  10.1186/s12958-020-00677-x
[44]

YU J, DING C F, HUA Z J, et al. Protective effects of berberine in a rat model of polycystic ovary syndrome mediated via the PI3K/AKT pathway[J]. J Obstet Gynaecol Res, 2021, 47(5):1789-1803. doi:  10.1111/jog.14730
[45]

LI T T, MO H, CHEN W F, et al. Role of the PI3K-Akt signaling pathway in the pathogenesis of polycystic ovary syndrome[J]. Reprod Sci, 2017, 24(5):646-655. doi:  10.1177/1933719116667606
[46]

YAO L H, WANG Q, ZHANG R J, et al. Brown adipose transplantation improves polycystic ovary syndrome-involved metabolome remodeling[J]. Front Endocrinol (Lausanne), 2021, 12:747944. doi:  10.3389/fendo.2021.747944
[47]

HU L M, ZHANG Y T, CHEN L, et al. MAPK and ERK polymorphisms are associated with PCOS risk in Chinese women[J]. Oncotarget, 2017, 8(59):100261-100268. doi:  10.18632/oncotarget.22153