[1] 郭三维, 琚建军, 李铮. 男性性腺功能减退症的认识与对策[J]. 上海医学, 2021, 44(5):302-306.
[2] 梁国庆, 刘晓强. 迟发性性腺功能减退症的诊治进展[J]. 中国男科学杂志, 2020, 34(5):83-88.
[3] 任健超, 王璟琦. 肥胖相关男性性腺功能减退症的研究进展[J]. 中国男科学杂志, 2020, 34(6):67-70.
[4] 洪露. 中西医结合治疗男性性腺功能减退的临床疗效分析[J]. 中西医结合心血管病电子杂志, 2019, 7(31): 183, 195.
[5] 闵潇, 解圣麟, 焦拥政. 中西医结合治疗迟发性性腺功能减退症的思路[J]. 中国中西医结合杂志, 2019, 39(3):365-368.
[6] 郁超, 龚华, 何晓锋, 等. 杞贞滋阴合剂治疗迟发性性腺功能减退症的临床评价[J]. 上海中医药杂志, 2017, 51(5):68-71.
[7] 郁超, 龚华, 何晓锋, 等. 麒麟丸联合杞贞滋阴合剂治疗迟发型性腺功能减退男性少弱精子症临床研究[J]. 中国男科学杂志, 2016, 30(11):45-49. doi:  10.3969/j.issn.1008-0848.2016.11.010
[8] 董培良, 李慧, 韩华. 中药网络药理学的应用与思考[J]. 中国实验方剂学杂志, 2020, 26(17):204-211.
[9]

HUANG L, XIE D L, YU Y R, et al. TCMID 2.0: a comprehensive resource for TCM[J]. Nucleic Acids Res, 2018, 46(D1):D1117-D1120. doi:  10.1093/nar/gkx1028
[10]

RU J, LI P, WANG J, et al. TCMSP: a database of systems pharmacology for drug discovery from herbal medicines[J]. J Cheminform, 2014, 6:13. doi:  10.1186/1758-2946-6-13
[11]

YE H, YE L, KANG H, et al. HIT: linking herbal active ingre-dients to targets[J]. Nucleic Acids Res, 2011, 39(Database issue): D1055-D1059.
[12]

KUHN M, SZKLARCZYK D, PLETSCHER-FRANKILD S, et al. STITCH 4: integration of protein-chemical interactions with user data[J]. Nucleic Acids Res, 2014, 42(Database issue): D401-D407.
[13]

BICKERTON G R, PAOLINI G V, BESNARD J, et al. Quantifying the chemical beauty of drugs[J]. Nat Chem, 2012, 4(2):90-98. doi:  10.1038/nchem.1243
[14]

LIANG X J, LI H Y, LI S. A novel network pharmacology approach to analyse traditional herbal formulae: the Liu-Wei-Di-Huang pill as a case study[J]. Mol Biosyst, 2014, 10(5):1014-1022. doi:  10.1039/C3MB70507B
[15]

SAFRAN M, DALAH I, ALEXANDER J, et al. GeneCards Version 3: the human gene integrator[J]. Database (Oxford), 2010, 2010:baq020.
[16]

KANEHISA M, FURUMICHI M, TANABE M, et al. KEGG: new perspectives on genomes, pathways, diseases and drugs[J]. Nucleic Acids Res, 2017, 45(D1):D353-D361. doi:  10.1093/nar/gkw1092
[17]

GOSSMANN A, ZILLE P, CALHOUN V, et al. FDR-corrected sparse canonical correlation analysis with applications to imaging genomics[J]. IEEE Trans Med Imaging, 2018, 37(8):1761-1774. doi:  10.1109/TMI.2018.2815583
[18] 何杰滢, 桂蓓, 陈艳芬, 等. 基于网络药理学及实验验证探讨良附丸治疗功能性消化不良的作用机制[J]. 中国中药杂志, 2022, 47(14):3853-3862.
[19]

TRAISH A M, ABDOU R, KYPREOS K E. Androgen deficiency and atherosclerosis: the lipid link[J]. Vascul Pharmacol, 2009, 51(5-6):303-313. doi:  10.1016/j.vph.2009.09.003
[20]

YEAP B B, CHUBB S A P, HYDE Z, et al. Lower serum testosterone is independently associated with insulin resistance in non-diabetic older men: the Health in Men Study[J]. Eur J Endocrinol, 2009, 161(4):591-598. doi:  10.1530/EJE-09-0348
[21]

BERG W T, MINER M. Hypogonadism and metabolic syndrome: review and update[J]. Curr Opin Endocrinol Diabetes Obes, 2020, 27(6):404-410. doi:  10.1097/MED.0000000000000582
[22]

CORONA G, MONAMI M, RASTRELLI G, et al. Type 2 diabetes mellitus and testosterone: a meta-analysis study[J]. Int J Androl, 2011, 34(6 Pt 1): 528-540.
[23]

DING E L, SONG Y Q, MALIK V S, et al. Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis[J]. JAMA, 2006, 295(11):1288-1299. doi:  10.1001/jama.295.11.1288
[24]

CORMIER M, GHOUILI F, ROUMAUD P, et al. Influence of flavonols and quercetin derivative compounds on MA-10 Leydig cells steroidogenic genes expressions[J]. Toxicol In Vitro, 2017, 44:111-121. doi:  10.1016/j.tiv.2017.06.027
[25]

BAI X, TANG Y B, LI Q, et al. An integrated analysis of network pharmacology, molecular docking, and experiment validation to explore the new candidate active component and mechanism of Cuscutae Semen-mori fructus coupled-herbs in treating oligoasthenozoospermia[J]. Drug Des Devel Ther, 2021, 15: 2059-2089.
[26]

COUTURE R, MORA N, BITTAR S A, et al. Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells[J]. Cell Biol Toxicol, 2020 , 36(1): 31-49.
[27]

WANG Y Y, CHEN L L, XIE L B, et al. Interleukin 6 inhibits the differentiation of rat stem Leydig cells[J]. Mol Cell Endocrinol, 2018, 472: 26-39.
[28]

XIE L B, LI X H, MO J Y, et al. Delayed puberty by ziram is associated with down regulation of testicular phosphorylated AKT1 and SIRT1/PGC-1α signaling[J]. Chem Res Toxicol, 2018 , 31(12): 1315-1322.
[29]

CARVALHEIRA J B, TORSONI M A, UENO M, et al. Cross-talk between the insulin and leptin signaling systems in rat hypothalamus[J]. Obes Res, 2005 , 13(1): 48-57.
[30]

WANG X T, ZOU Z R, YANG Z H, et al. HIF 1 inhibits StAR transcription and testosterone synthesis in murine Leydig cells[J]. J Mol Endocrinol,2018 Oct 1:JME-18-0148.R2.
[31]

LEE S, DONG H H. FoxO integration of insulin signaling with glucose and lipid metabolism[J]. J Endocrinol, 2017, 233(2):R67-R79. doi:  10.1530/JOE-17-0002
[32]

XU W D, ZHU Q, ZHANG B, et al. Protective effect of calretinin on testicular Leydig cells via the inhibition of apoptosis[J]. Aging, 2017, 9(4): 1269-1279.
[33]

OGHBAEI H, FATTAHI A, HAMIDIAN G, et al. A closer look at the role of insulin for the regulation of male reproduc-tive function[J]. Gen Comp Endocrinol, 2021 , 300: 1-36.
[34] 杜丽坤, 宋昕, 李娟. 从肝脾肾三脏探讨肥胖型糖尿病前期患者胰岛素抵抗[J]. 中医药学报, 2023, 51(7):62-66. doi:  10.19664/j.cnki.1002-2392.230150