[1] LIU J Y, LI W, DENG K Q, et al. The E3 ligase TRIM16 is a key suppressor of pathological cardiac hypertrophy[J]. Circ Res, 2022, 130(10): 1586-1600. doi:  10.1161/CIRCRESAHA.121.318866
[2] YUAN J, LIU H B, GAO W, et al. MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress[J]. Theranostics, 2018, 8(9): 2565-2582. doi:  10.7150/thno.22878
[3] DENG K Q, ZHAO G N, WANG Z H, et al. Targeting transmembrane BAX inhibitor motif containing 1 alleviates pathological cardiac hypertrophy[J]. Circulation, 2018, 137(14): 1486-1504. doi:  10.1161/CIRCULATIONAHA.117.031659
[4] ZHAO G J, ZHAO C L, OUYANG S, et al. Ca2+-dependent NOX5 (NADPH oxidase 5) exaggerates cardiac hypertrophy through reactive oxygen species production[J]. Hypertension, 2020, 76(3): 827-838. doi:  10.1161/HYPERTENSIONAHA.120.15558
[5] ZHOU H, LI Y J, WANG M, et al. Involvement of RhoA/ROCK in myocardial fibrosis in a rat model of type 2 diabetes[J]. Acta Pharmacol Sin, 2011, 32(8): 999-1008. doi:  10.1038/aps.2011.54
[6] KANLAYA R, THONGBOONKERD V. Persistent Escherichia coli infection in renal tubular cells enhances calcium oxalate crystal-cell adhesion by inducing ezrin translocation to apical membranes via Rho/ROCK pathway[J]. Cell Mol Life Sci, 2022, 79(7): 381. doi:  10.1007/s00018-022-04414-y
[7] FENG H, ZHU X Y, TANG Y, et al. Astragaloside Ⅳ ameliorates diabetic nephropathy in db/db mice by inhibiting NLRP3 inflammasome-mediated inflammation[J]. Int J Mol Med, 2021, 48(2): 164. doi:  10.3892/ijmm.2021.4996
[8] 底雪梅, 袁曜晖, 张超, 等. 黄芪甲苷抑制U937巨噬细胞CCL18表达及其作用机制研究[J]. 药学实践杂志, 2019, 37(1): 32-36, 41.
[9]

ZHANG X, QU H, YANG T, et al. Astragaloside Ⅳ attenuate MI-induced myocardial fibrosis and cardiac remodeling by inhibiting ROS/caspase-1/GSDMD signaling pathway[J]. Cell Cycle, 2022, 21(21): 2309-2322. doi:  10.1080/15384101.2022.2093598
[10]

CHEN Y M, GE Z W, HUANG S X, et al. Delphinidin attenuates pathological cardiac hypertrophy via the AMPK/NOX/MAPK signaling pathway[J]. Aging, 2020, 12(6): 5362-5383. doi:  10.18632/aging.102956
[11]

LIU W J, WANG G, ZHANG C C, et al. MG53, A novel regulator of KChIP2 and Ito, f, plays a critical role in electrophysiological remodeling in cardiac hypertrophy[J]. Circulation, 2019, 139: 2142-2156. doi:  10.1161/CIRCULATIONAHA.118.029413
[12]

LIN H B, NAITO K, OH Y, et al. Innate immune Nod1/RIP2 signaling is essential for cardiac hypertrophy but requires mitochondrial antiviral signaling protein for signal transductions and energy balance[J]. Circulation, 2020, 142(23): 2240-2258. doi:  10.1161/CIRCULATIONAHA.119.041213
[13]

LI P L, LIU H, CHEN G P, et al. STEAP3 (Six-transmembrane epithelial antigen of prostate 3) inhibits pathological cardiac hypertrophy[J]. Hypertension, 2020, 76(4): 1219-1230. doi:  10.1161/HYPERTENSIONAHA.120.14752
[14]

WU X Q, LIU Z M, YU X Y, et al. Autophagy and cardiac diseases: therapeutic potential of natural products[J]. Med Res Rev, 2021, 41(1): 314-341. doi:  10.1002/med.21733
[15]

VANHOUTTE D, SCHIPS T G, VO A, et al. Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy[J]. Nat Commun, 2021, 12(1): 3928. doi:  10.1038/s41467-021-24215-4
[16]

TONG M M, SAITO T, ZHAI P Y, et al. Alternative mitophagy protects the heart against obesity-associated cardiomyopathy[J]. Circ Res, 2021, 129(12): 1105-1121. doi:  10.1161/CIRCRESAHA.121.319377
[17]

DENG Z H, JIA Y M, LIU H F, et al. RhoA/ROCK pathway: implication in osteoarthritis and therapeutic targets[J]. Am J Transl Res, 2019, 11(9): 5324-5331.
[18]

WANG Z H, REN D B, ZHENG P. The role of Rho/ROCK in epileptic seizure-related neuronal damage[J]. Metab Brain Dis, 2022, 37(4): 881-887. doi:  10.1007/s11011-022-00909-6
[19]

DIETERLE M P, HUSARI A, STEINBERG T, et al. Role of mechanotransduction in periodontal homeostasis and disease[J]. J Dent Res, 2021, 100(11): 1210-1219. doi:  10.1177/00220345211007855
[20]

GUO M, XU J M, WANG S W, et al. Asiaticoside reduces autophagy and improves memory in a rat model of dementia through mTOR signaling pathway regulation[J]. Mol Med Rep, 2021, 24(3): 645. doi:  10.3892/mmr.2021.12284
[21]

LI Y C, WANG H H, ZHANG R, et al. Antitumor activity of asiaticoside against multiple myeloma drug-resistant cancer cells is mediated by autophagy induction, activation of effector caspases, and inhibition of cell migration, invasion, and STAT-3 signaling pathway[J]. Med Sci Monit, 2019, 25: 1355-1361. doi:  10.12659/MSM.913397