[1] RIAL M D E L C, ABBUD-FILHO M, GONÇALVES R T, et al. Individualizing early use of sirolimus in renal transplantation[J]. Transplant Proc,2010,42(10):4518-4525. doi:  10.1016/j.transproceed.2010.10.015
[2] TOSO C, MERANI S, BIGAM D L, et al. Sirolimus-based immunosuppression is associated with increased survival after liver transplantation for hepatocellular carcinoma[J]. Hepatology,2010,51(4):1237-1243. doi:  10.1002/hep.23437
[3] CHATEL M A, LARKIN D F. Sirolimus and mycophenolate as combination prophylaxis in corneal transplant recipients at high rejection risk[J]. Am J Ophthalmol,2010,150(2):179-184. doi:  10.1016/j.ajo.2010.03.010
[4] POUTON C W. Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system[J]. Eur J Pharm Sci,2006,29(3-4):278-287. doi:  10.1016/j.ejps.2006.04.016
[5] RICCIUTELLI M, DI MARTINO P, BARBONI L, et al. Evaluation of rapamycin chemical stability in volatile-organic solvents by HPLC[J]. J Pharm Biomed Anal,2006,41(3):1070-1074. doi:  10.1016/j.jpba.2006.02.009
[6] BALAKRISHNAN P, LEE B, OH D H, et al. Enhanced oral bioavailability of dexibuprofen by a novel solid Self-emulsifying drug delivery system (SEDDS)[J]. Eur J Pharm Biopharm,2009,72(3):539-545. doi:  10.1016/j.ejpb.2009.03.001
[7] CHO H Y, CHOI J H, OH I J, et al. Self-emulsifying drug delivery system for enhancing bioavailability and lymphatic delivery of tacrolimus[J]. J Nanosci Nanotechnol,2015,15(2):1831-1841. doi:  10.1166/jnn.2015.9248
[8] 余越, 陶春, 杨海跃, 等. 不同孔径介孔二氧化硅纳米粒的制备及其用于固化西罗莫司自微乳[J]. 药学学报, 2017, 52(6):985-991.
[9]

HU X W, LIN C, CHEN D X, et al. Sirolimus solid self-microemulsifying pellets: formulation development, characterization and bioavailability evaluation[J]. Int J Pharm,2012,438(1-2):123-133. doi:  10.1016/j.ijpharm.2012.07.055
[10] 吴昊, 宋洪涛. 西罗莫司纳米结构脂质载体分散液的制备及其体外释放度考察[J]. 药学实践杂志, 2012, 30(3):189-193. doi:  10.3969/j.issn.1006-0111.2012.03.009
[11] 吴昊, 张晶, 宋洪涛. 西罗莫司纳米脂质载体固化制剂的制备[J]. 中国医药工业杂志, 2012, 43(7):562-567. doi:  10.3969/j.issn.1001-8255.2012.07.013
[12] 刘志宏, 胡雄伟, 张晶, 等. 西罗莫司固体自微乳化给药系统的体内外评价[J]. 中国新药杂志, 2016, 25(20):2369-2375.
[13] 霍涛涛, 张美敬, 陶春, 等. 基于多组分评价的雷公藤提取物固体分散体的制备及体外表征[J]. 中草药, 2018, 49(1):128-134. doi:  10.7501/j.issn.0253-2670.2018.01.018
[14]

SUN M H, SI L Q, ZHAI X Z, et al. The influence of co-solvents on the stability and bioavailability of rapamycin formulated in self-microemulsifying drug delivery systems[J]. Drug Dev Ind Pharm,2011,37(8):986-994. doi:  10.3109/03639045.2011.553618
[15] 侯明明, 宋洪涛, 周欣. 免疫抑制剂药物基因组学的研究进展[J]. 中国药房, 2009, 20(31):2471-2473.
[16] 董文雪, 何军, 杨亚妮. 自微乳释药系统研究进展[J]. 中国医药工业杂志, 2011, 42(12):948-954. doi:  10.3969/j.issn.1001-8255.2011.12.020
[17] 刘建清, 张晶, 赵佳丽, 等. 纳米结构脂质载体促进难溶性药物口服吸收机制的研究进展[J]. 药学实践杂志, 2014, 32(4):254-256, 277. doi:  10.3969/j.issn.1006-0111.2014.04.004
[18] 王学功. 几种β-环糊精衍生物的合成及对药物分子的包结作用[D]. 天津: 天津大学, 2005.
[19] 刘志宏, 胡雄伟, 陶春, 等. 西罗莫司自乳化给药系统及其固体化研究[J]. 药学实践杂志, 2016, 34(2):142-147, 170. doi:  10.3969/j.issn.1006-0111.2016.02.012
[20]

GUMASTE S G, PAWLAK S A, DALRYMPLE D M, et al. Development of solid SEDDS, IV: effect of adsorbed lipid and surfactant on tableting properties and surface structures of different silicates[J]. Pharm Res,2013. doi:  10.1007/s11095-013-1114-4
[21]

LEE D H, YEOM D W, SONG Y S, et al. Improved oral absorption of dutasteride via Soluplus®-based supersaturable self-emulsifying drug delivery system (S-SEDDS)[J]. Int J Pharm,2015,478(1):341-347. doi:  10.1016/j.ijpharm.2014.11.060
[22] 刘静. 自微乳释药系统在西药制剂中的应用[J]. 中国药业, 2018, 27(1):4-8. doi:  10.3969/j.issn.1006-4931.2018.01.002
[23] 徐晓琰, 恽菲, 狄留庆, 等. 环糊精包合药物胃肠道转运过程及机制研究进展[J]. 中草药, 2012, 43(10):2062-2065.