ZHANG Lingna, WANG Tianyu, HONG Wanfeng, TAO Chun, SONG Hongtao. Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(4): 301-306. doi: 10.12206/j.issn.1006-0111.201910082
Citation:
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ZHANG Lingna, WANG Tianyu, HONG Wanfeng, TAO Chun, SONG Hongtao. Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material[J]. Journal of Pharmaceutical Practice and Service, 2020, 38(4): 301-306. doi: 10.12206/j.issn.1006-0111.201910082
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Preparation and formulation optimization of wound dressings with nitrocellu-lose as membrane material
- Received Date: 2019-10-25
- Rev Recd Date:
2020-03-16
Available Online:
2020-07-27
- Publish Date:
2020-07-25
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Abstract
Objective To prepare a wound dressing using nitrocellulose as a membrane and optimize its formulation. Methods Partial analysis was performed on commercial available products. The wound dressings were prepared by using nitrocellulose as a film-forming material, benzyl alcohol as a bacteriostatic agent, castor oil as a plasticizer, isopropyl palmitate as a skin emollient, camphor as a fragrance, and isopropyl alcohol, ethyl acetate and butyl acetate as volatile solvent. The tensile strength, breakpoint elongation percentage, breathability and waterproof performance were tested and evaluated. Results The film-forming performance of the prepared liquid wound dressing was good. The final use amount of nitrocellulose was determined to be 6%. The use amount of plasticizer castor oil was determined to be 4%. Conclusion The prepared liquid wound dressing has good film-forming property, good mechanical property, good waterproof and certain breathability.
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Proportional views
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