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外周神经系统(PNS)是中枢神经系统发出,导向人体各部分的神经,也称周围神经系统。外周神经的主要成分是神经纤维,包括传入神经纤维和传出神经纤维。外周神经损伤约占所有创伤的2.8%[1],可导致患者的感觉与运动功能发生障碍。外周神经损伤后机体自身有一定的再生能力但修复速度很慢,因此,借助药物途径促进外周神经再生修复是临床治疗的关键[2-3]。了解与外周神经再生相关的信号通路,有助于外周神经损伤后修复药物的研发。
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