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神经炎症是外周血液系统和中枢神经系统中免疫细胞活化和浸润、神经胶质细胞活化和炎性介质产生的过程[1]。脊髓中产生的炎性神经胶质介质调节突触传递,诱导和维持慢性疼痛,并提供神经炎症和慢性疼痛之间的联系[2]。炎症疼痛是一种常见的慢性疾病,以往研究提示,前动力蛋白(prokineticin,PK)系统参与组织损伤和神经损伤后的外周和中枢敏化,其在炎症疼痛中的作用已经被证实[3]。本文针对近年发表的有关PK系统参与炎症疼痛的研究文献,回顾性分析该镇痛靶点所发挥的镇痛机制。
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