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丙戊酸钠是一种临床常用的抗癫痫药物,用于治疗全身和部分发作类型的癫痫,同时,丙戊酸钠也可用于治疗与双向情感障碍相关的躁狂发作[1]。丙戊酸钠中毒可能偶然发生,也可能是有意而为之,尤其是对有自残意图的患者[2]。急性丙戊酸钠中毒通常表现为中枢神经系统抑制、肝酶升高、血氨升高和电解质紊乱,如高钠血症等。严重过量使用丙戊酸钠的患者可出现低血压、心动过速、呼吸抑制、代谢性酸中毒、脑水肿等,如果不积极治疗,可进展为昏迷甚至死亡[3]。本文报道一例丙戊酸钠中毒患者的救治过程,为临床救治药物中毒患者中如何发挥临床药师的作用提供参考。
Analysis of clinical pharmacists participating in the treatment of a case of sodium valproate poisoning
doi: 10.12206/j.issn.1006-0111.202103017
- Received Date: 2021-01-17
- Rev Recd Date: 2021-08-30
- Available Online: 2021-12-27
- Publish Date: 2021-11-25
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Key words:
- sodium valproate /
- poisoning /
- blood drug concentration monitoring /
- blood purification /
- hemoperfusion /
- clinical pharmacists.
Abstract:
Citation: | ZHANG Jingming, LU Wenjie, ZHOU Shuqin, ZHAO Jian, WAN Honghong, ZHUANG Yugang. Analysis of clinical pharmacists participating in the treatment of a case of sodium valproate poisoning[J]. Journal of Pharmaceutical Practice and Service, 2021, 39(6): 566-568. doi: 10.12206/j.issn.1006-0111.202103017 |