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脓毒症(sepsis)是由于宿主对细菌、真菌、病毒等感染的反应失调而引起的多器官功能障碍,具有很高的致死率,是感染致死的首要原因[1]。近年来,虽然人类在重症监护领域已经取得了长足的进步,但是严重脓毒症的总死亡率仍高达26.7%[2]。针对脓毒症的治疗,目前绝大多数仍是采用支持性疗法,临床可用的干预措施只有非常有限的几种,如液体复苏、应用抗生素和类固醇药物等。然而,这些措施往往收效甚微。因此,研发抗脓毒症新药, 从而改善患者预后,降低脓毒症死亡率,是目前亟待解决的问题。本文将就近年来脓毒症治疗相关的研究进行综述,以期为今后抗脓毒症的研究提供思路。
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