Progress on induced pluripotent stem cell

SONG Jie; MIAO Chao-yu

doi:10.3969/j.issn.1006-0111.2012.01.001

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Volume 30 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(1): 1-3,13

SONG Jie, MIAO Chao-yu. Progress on induced pluripotent stem cell[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 1-3,13. doi: 10.3969/j.issn.1006-0111.2012.01.001

Citation:

SONG Jie, MIAO Chao-yu. Progress on induced pluripotent stem cell[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 1-3,13. doi: 10.3969/j.issn.1006-0111.2012.01.001

Progress on induced pluripotent stem cell

doi: 10.3969/j.issn.1006-0111.2012.01.001

Department of Pharmacology, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-05-06
Rev Recd Date: 2011-06-08

Abstract

The IPSC technology, which was discovered in 2006, had drawn much attention among laboratories around the world and become a new milestone in the life science. The history of pluripotency study, with an emphasis on the culturing technology of IPSC and its potential applications in cell therapy was reviewed. According to the large amount of reviews and articles, the progress that had been made in the IPSC field in recent years in hope to provide some references for the subsequent research.
- pluripotent cell,
- IPSC culturing technology,
- cell therapy

References

[1]	Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J]. Cell, 2006, 126(4): 663.
[2]	Briggs R, King TJ. Transplantation of living nuclei from blastula cells into enucleated frogs'eggs[J]. Proc Natl Acad Sci,1952, 38(5): 455.
[3]	Miller RA, Ruddle FH. Pluripotent teratocarcinoma-thymus somatic cell hybrids[J]. Cell,1976,9(1): 45.
[4]	Xie H, Ye M, Feng R, et al. Stepwise reprogramming of B cells into macrophages[J]. Cell,2004, 117(5): 663.
[5]	Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts[J]. Cell,1987, 51(6): 987.
[6]	Ieda M, Fu JD, Delgado-Olguin P, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors[J]. Cell,2010, 142(3): 375.
[7]	Aasen T, Raya A, Barrero MJ, et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes[J]. Nat Biotechnol,2008, 26(11): 1276.
[8]	Eminli S, Utikal J, Arnold K, et al. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression[J]. Stem Cells,2008, 26(10): 2467.
[9]	Utikal J, Maherali N, Kulalert W, et al. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells[J]. J Cell Sci,2009, 122(Pt 19): 3502.
[10]	Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of pancreatic β cells into induced pluripotent stem cells[J]. Curr Biol,2008, 18(12): 890.
[11]	Sun N, Panetta NJ, Gupta DM, et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells[J]. Proc Natl Acad Sci USA, 2009,106(37):15720.
[12]	Hanna J, Markoulaki S, Schorderet P, et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency[J]. Cell,2008, 133(2): 250.
[13]	Zhao XY, Li W, Lv Z, et al. iPS cells produce viable mice through tetraploid complementation[J]. Nature,2009, 461(7260): 86.
[14]	Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells[J]. Nature,2007, 448(7151): 313.
[15]	Stadtfeld M, Nagaya M, Utikal J, et al. Induced pluripotent stem cells generated without viral integration[J]. Science,2008, 322(5903): 945.
[16]	Varas F, Stadtfeld M, de Andres-Aguayo L, et al. Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions[J]. Stem Cells,2009, 27(2): 300.
[17]	Fusaki N, Ban H, Nishiyama A, et al. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome[J]. Proc Jpn Acad,2009, 85(8): 348.
[18]	Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem cells free of vector and transgene sequences[J]. Science,2009, 324(5928): 797.
[19]	Jia F, Wilson KD, Sun N, et al. A nonviral minicircle vector for deriving human iPS cells[J]. Nat Methods,2010, 7(3): 197.
[20]	Woltjen K, Michael IP, Mohseni P, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells[J]. Nature,2009, 458(7239): 766.
[21]	Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins[J]. Cell Stem Cell,2009, 4(5): 381.
[22]	Cho HJ, Lee CS, Kwon YW, et al. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation[J]. Blood,2010, 116(3): 386.
[23]	Desponts C, Ding S. Using small molecules to improve generation of induced pluripotent stem cells from somatic cells[J]. Methods Mol Biol,2010, 636: 207.
[24]	Park IH, Arora N, Huo H, et al. Disease-specific induced pluripotent stem cells[J]. Cell,2008, 134(5): 877.
[25]	Ebert AD, Yu J, Rose FF Jr, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient[J]. Nature,2009, 457(7227): 277.
[26]	Lee G, Papapetrou EP, Kim H, et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs[J]. Nature,2009,461(7262): 402.
[27]	Carvajal-Vergara X, Sevilla A, D'Souza SL, et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome[J]. Nature,2010,465(7299): 808.
[28]	Hanna J, Wernig M, Markoulaki S, et al.Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin[J]. Science,2007, 318(5858): 1920.
[29]	M. Wernig, J. Pruszak, E. Hedlund, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease[J].Proc Natl Acad Sci,2008,105(15) : 5856.
[30]	D. Xu, LM. Fink, DM. Adcock, et al. Phenotypic correction ofmurine hemophilia A using an iPS cell-based therapy[J]. Proc Natl Acad Sci,2009,106(3) :808.
[31]	T.J. Nelson, S. Yamada, C. Perez-Terzic, et al. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells[J].Circ,2009,120(5) :408.
[32]	Raya A, Rodriguez-Piza I, Guenechea G et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells[J]. Nature,2009, 460(7251):53.
[33]	Couzin J. Celebration and concern over U.S. trial of embryonic stem cells[J]. Science,2009,323(5914):568.

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通讯作者: 陈斌, bchen63@163.com

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Progress on induced pluripotent stem cell

Department of Pharmacology, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-05-06

Rev Recd Date: 2011-06-08

Key words:

Abstract: The IPSC technology, which was discovered in 2006, had drawn much attention among laboratories around the world and become a new milestone in the life science. The history of pluripotency study, with an emphasis on the culturing technology of IPSC and its potential applications in cell therapy was reviewed. According to the large amount of reviews and articles, the progress that had been made in the IPSC field in recent years in hope to provide some references for the subsequent research.

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Reference (33)

[1]	Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors[J]. Cell, 2006, 126(4): 663.
[2]	Briggs R, King TJ. Transplantation of living nuclei from blastula cells into enucleated frogs'eggs[J]. Proc Natl Acad Sci,1952, 38(5): 455.
[3]	Miller RA, Ruddle FH. Pluripotent teratocarcinoma-thymus somatic cell hybrids[J]. Cell,1976,9(1): 45.
[4]	Xie H, Ye M, Feng R, et al. Stepwise reprogramming of B cells into macrophages[J]. Cell,2004, 117(5): 663.
[5]	Davis RL, Weintraub H, Lassar AB. Expression of a single transfected cDNA converts fibroblasts to myoblasts[J]. Cell,1987, 51(6): 987.
[6]	Ieda M, Fu JD, Delgado-Olguin P, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors[J]. Cell,2010, 142(3): 375.
[7]	Aasen T, Raya A, Barrero MJ, et al. Efficient and rapid generation of induced pluripotent stem cells from human keratinocytes[J]. Nat Biotechnol,2008, 26(11): 1276.
[8]	Eminli S, Utikal J, Arnold K, et al. Reprogramming of neural progenitor cells into induced pluripotent stem cells in the absence of exogenous Sox2 expression[J]. Stem Cells,2008, 26(10): 2467.
[9]	Utikal J, Maherali N, Kulalert W, et al. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells[J]. J Cell Sci,2009, 122(Pt 19): 3502.
[10]	Stadtfeld M, Brennand K, Hochedlinger K. Reprogramming of pancreatic β cells into induced pluripotent stem cells[J]. Curr Biol,2008, 18(12): 890.
[11]	Sun N, Panetta NJ, Gupta DM, et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells[J]. Proc Natl Acad Sci USA, 2009,106(37):15720.
[12]	Hanna J, Markoulaki S, Schorderet P, et al. Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency[J]. Cell,2008, 133(2): 250.
[13]	Zhao XY, Li W, Lv Z, et al. iPS cells produce viable mice through tetraploid complementation[J]. Nature,2009, 461(7260): 86.
[14]	Okita K, Ichisaka T, Yamanaka S. Generation of germline-competent induced pluripotent stem cells[J]. Nature,2007, 448(7151): 313.
[15]	Stadtfeld M, Nagaya M, Utikal J, et al. Induced pluripotent stem cells generated without viral integration[J]. Science,2008, 322(5903): 945.
[16]	Varas F, Stadtfeld M, de Andres-Aguayo L, et al. Fibroblast-derived induced pluripotent stem cells show no common retroviral vector insertions[J]. Stem Cells,2009, 27(2): 300.
[17]	Fusaki N, Ban H, Nishiyama A, et al. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome[J]. Proc Jpn Acad,2009, 85(8): 348.
[18]	Yu J, Hu K, Smuga-Otto K, et al. Human induced pluripotent stem cells free of vector and transgene sequences[J]. Science,2009, 324(5928): 797.
[19]	Jia F, Wilson KD, Sun N, et al. A nonviral minicircle vector for deriving human iPS cells[J]. Nat Methods,2010, 7(3): 197.
[20]	Woltjen K, Michael IP, Mohseni P, et al. piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells[J]. Nature,2009, 458(7239): 766.
[21]	Zhou H, Wu S, Joo JY, et al. Generation of induced pluripotent stem cells using recombinant proteins[J]. Cell Stem Cell,2009, 4(5): 381.
[22]	Cho HJ, Lee CS, Kwon YW, et al. Induction of pluripotent stem cells from adult somatic cells by protein-based reprogramming without genetic manipulation[J]. Blood,2010, 116(3): 386.
[23]	Desponts C, Ding S. Using small molecules to improve generation of induced pluripotent stem cells from somatic cells[J]. Methods Mol Biol,2010, 636: 207.
[24]	Park IH, Arora N, Huo H, et al. Disease-specific induced pluripotent stem cells[J]. Cell,2008, 134(5): 877.
[25]	Ebert AD, Yu J, Rose FF Jr, et al. Induced pluripotent stem cells from a spinal muscular atrophy patient[J]. Nature,2009, 457(7227): 277.
[26]	Lee G, Papapetrou EP, Kim H, et al. Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs[J]. Nature,2009,461(7262): 402.
[27]	Carvajal-Vergara X, Sevilla A, D'Souza SL, et al. Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome[J]. Nature,2010,465(7299): 808.
[28]	Hanna J, Wernig M, Markoulaki S, et al.Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin[J]. Science,2007, 318(5858): 1920.
[29]	M. Wernig, J. Pruszak, E. Hedlund, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease[J].Proc Natl Acad Sci,2008,105(15) : 5856.
[30]	D. Xu, LM. Fink, DM. Adcock, et al. Phenotypic correction ofmurine hemophilia A using an iPS cell-based therapy[J]. Proc Natl Acad Sci,2009,106(3) :808.
[31]	T.J. Nelson, S. Yamada, C. Perez-Terzic, et al. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells[J].Circ,2009,120(5) :408.
[32]	Raya A, Rodriguez-Piza I, Guenechea G et al. Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells[J]. Nature,2009, 460(7251):53.
[33]	Couzin J. Celebration and concern over U.S. trial of embryonic stem cells[J]. Science,2009,323(5914):568.

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Progress on induced pluripotent stem cell

doi: 10.3969/j.issn.1006-0111.2012.01.001

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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