Progress on extracellularly activated nanocarriers

WANG Xiao-yu; GAO Jing; ZHANG Wei; ZHU Quan-gang; WU Xin; GAO Shen

doi:10.3969/j.issn.1006-0111.2012.01.002

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Both the stealth and targeting features were important for effective and selective drug delivery to the tumors.However, it was difficult to achieve both features simultaneously. Some of the novel targeting strategies had the potential to overcome this challenge. The new targeting technologies with recent examples were reviewed, which utilized the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers were briefly discussed with an emphasis on their achievements and challenges.

Progress on extracellularly activated nanocarriers

1. Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China

2. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

3. The 522th Hospital of PLA,Luoyang,Henan 471003,China

Received Date: 2011-05-07

Rev Recd Date: 2011-06-02

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Abstract: Both the stealth and targeting features were important for effective and selective drug delivery to the tumors.However, it was difficult to achieve both features simultaneously. Some of the novel targeting strategies had the potential to overcome this challenge. The new targeting technologies with recent examples were reviewed, which utilized the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers were briefly discussed with an emphasis on their achievements and challenges.

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Progress on extracellularly activated nanocarriers

doi: 10.3969/j.issn.1006-0111.2012.01.002

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