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Volume 30 Issue 1
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(1): 32-34

CHEN Hao, DAI Jun-dong, WANG Yu-rong, ZHU Nian-qing, SUN Yi-kun, WANG Yue, GONG Wei-hong. Preparation of quercetin liposome by film-ultrasonic technique[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 32-34. doi: 10.3969/j.issn.1006-0111.2012.01.008
Citation: CHEN Hao, DAI Jun-dong, WANG Yu-rong, ZHU Nian-qing, SUN Yi-kun, WANG Yue, GONG Wei-hong. Preparation of quercetin liposome by film-ultrasonic technique[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 32-34. doi: 10.3969/j.issn.1006-0111.2012.01.008
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Preparation of quercetin liposome by film-ultrasonic technique

doi: 10.3969/j.issn.1006-0111.2012.01.008

  • School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China

  • Received Date: 2011-05-27
  • Rev Recd Date: 2011-06-27
  • Objective To study the preparation method of quercetin liposome and screen the optimal technological conditions by the particle sizes and the encapsulation efficiencies of quercetin. Method Liposomes were made of hydrogenated soybean phosphatidylcholine(HSPC) and cholesterol(CH) by film evaporation and probe ultrasonic technique, then orthogonal design was adopted to screen the optimal conditions. The particle sizes were detected by Zetasizer Nano, while the encapsulation efficiency of quercetin (QU) were determined by HPLC after the free drug was separated by protamine sedimentation method. Results The optimal technological conditions of quercetin liposome were as follows: HSPC∶CH=3∶1, HSPC:QU=20:1, the time of probe ultrasonic (600 w) was 9 minutes. Conclusion Film evaporation and probe ultrasonic technique could be suitable for laboratory to prepare quercetin liposome.
  • [1] 王 黎,侯宝光,侯新朴,等.氢化与非氢化卵磷脂对阿霉素脂质体体内外稳定性的影响[J].药学学报,2001,36(6):444.
    [2] 丁燕飞,姚 瑶,陶昱斐,等.槲皮素纳米脂质体的处方工艺优化[J].中草药,2008,39(4):522.
    [3] 孙维彤,黄桂华,叶杰胜,等.鱼精蛋白凝聚法测定脂质体和纳米脂质体包封率[J].中国药学杂志,2006,41(22):1717.
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Preparation of quercetin liposome by film-ultrasonic technique

doi: 10.3969/j.issn.1006-0111.2012.01.008
  • School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100102, China
  • Received Date: 2011-05-27
  • Rev Recd Date: 2011-06-27

Abstract: Objective To study the preparation method of quercetin liposome and screen the optimal technological conditions by the particle sizes and the encapsulation efficiencies of quercetin. Method Liposomes were made of hydrogenated soybean phosphatidylcholine(HSPC) and cholesterol(CH) by film evaporation and probe ultrasonic technique, then orthogonal design was adopted to screen the optimal conditions. The particle sizes were detected by Zetasizer Nano, while the encapsulation efficiency of quercetin (QU) were determined by HPLC after the free drug was separated by protamine sedimentation method. Results The optimal technological conditions of quercetin liposome were as follows: HSPC∶CH=3∶1, HSPC:QU=20:1, the time of probe ultrasonic (600 w) was 9 minutes. Conclusion Film evaporation and probe ultrasonic technique could be suitable for laboratory to prepare quercetin liposome.

CHEN Hao, DAI Jun-dong, WANG Yu-rong, ZHU Nian-qing, SUN Yi-kun, WANG Yue, GONG Wei-hong. Preparation of quercetin liposome by film-ultrasonic technique[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 32-34. doi: 10.3969/j.issn.1006-0111.2012.01.008
Citation: CHEN Hao, DAI Jun-dong, WANG Yu-rong, ZHU Nian-qing, SUN Yi-kun, WANG Yue, GONG Wei-hong. Preparation of quercetin liposome by film-ultrasonic technique[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 32-34. doi: 10.3969/j.issn.1006-0111.2012.01.008
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