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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(1): 49-51,63

CAI Tongkai, LIU Mouzhi, DENG Jie, CAO Yongbing, YAN Lan. Research progress on action mechanism and clinical application of hyaluronic acid[J]. Journal of Pharmaceutical Practice and Service, 2022, 40(2): 103-107, 131. doi: 10.12206/j.issn.1006-0111.202108002
Citation: LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
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Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC

doi: 10.3969/j.issn.1006-0111.2012.01.013
  • 1.

    School of Pharmacy, Zhejiang University, Hangzhou 310012, China;Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China

  • 2.

    Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China

  • 3.

    School of Pharmacy, Zhejiang University, Hangzhou 310012, China

  • Received Date: 2011-04-29
  • Rev Recd Date: 2011-10-08
  • Objective To establish a HPLC method to determine the content and related substance of rosiglitazone hydrochloride tablets. Methods The analysis was achieved on a Diamonsil C18 column(250 mm×4.6 mm, 5 μm) using a mobile phase of 0.025 mol/L ammonium acetate-acetonitrile (50∶50). The detection wavelength was at 245 nm. Results There was good resolution among the peak of rosiglitazone, the main related substances and the degradable impurities after being destroyed. There was a good linear relationship between the peak area and the concentration of rosiglitazone in the range of 19.57~195.70 μg/ml (r=1.000 0, n=6). Regression equation could be expressed by A=68 525C+31 152, r=1.000 0 (n=6). The precision in a day (RSD﹤0.5%) and during the days (RSD﹤1.0%) were good. The average recovery was 99.8% (RSD=0.3%,n=9) and the limit of detection was 0.29 ng. The solution was stable for 10 hours. Conclusion The method was specific, accurate, sensitive and could be used to determine rosiglitazone.
  • [1] 王幼君,李淑芬.茄尼醇和尼古丁的提取与工艺研究[J].天津化工,2003,17(3):37.
    [2] 邹俊杰,曲 卫,冯晓云.盐酸罗格列酮片治疗2型糖尿病的疗效及安全性[J].药学服务与研究,2008,8(3):174.
    [3] 朱光宇.罗格列酮的临床应用进展[J].安徽医药,2005,9(9):644.
    [4] 郑国钢,方滢芝.RP-HPLC法测定盐酸罗格列酮含量及有关物质[J].药物分析杂志,2005,25(1):104.
    [5] 王国俊, 叶晓琳, 傅 萍.HPLC法测定复方罗格列酮盐酸二甲双胍片中罗格列酮的含量[J].中国药房,2009,20(1):57.
    [6] 庞晓华,陈春水.马来酸罗格列酮缓释片有关物质的测定[J].中国医药导报,2008,5(14):29.
    [7] 高立军,王维贤,梅兴国.高效液相色谱法测定罗格列酮钠片含量及有关物质[J].科学技术与工程,2006,6(12):1678.
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Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC

doi: 10.3969/j.issn.1006-0111.2012.01.013
  • 1. School of Pharmacy, Zhejiang University, Hangzhou 310012, China;Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
  • 2. Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
  • 3. School of Pharmacy, Zhejiang University, Hangzhou 310012, China
  • Received Date: 2011-04-29
  • Rev Recd Date: 2011-10-08

Abstract: Objective To establish a HPLC method to determine the content and related substance of rosiglitazone hydrochloride tablets. Methods The analysis was achieved on a Diamonsil C18 column(250 mm×4.6 mm, 5 μm) using a mobile phase of 0.025 mol/L ammonium acetate-acetonitrile (50∶50). The detection wavelength was at 245 nm. Results There was good resolution among the peak of rosiglitazone, the main related substances and the degradable impurities after being destroyed. There was a good linear relationship between the peak area and the concentration of rosiglitazone in the range of 19.57~195.70 μg/ml (r=1.000 0, n=6). Regression equation could be expressed by A=68 525C+31 152, r=1.000 0 (n=6). The precision in a day (RSD﹤0.5%) and during the days (RSD﹤1.0%) were good. The average recovery was 99.8% (RSD=0.3%,n=9) and the limit of detection was 0.29 ng. The solution was stable for 10 hours. Conclusion The method was specific, accurate, sensitive and could be used to determine rosiglitazone.

CAI Tongkai, LIU Mouzhi, DENG Jie, CAO Yongbing, YAN Lan. Research progress on action mechanism and clinical application of hyaluronic acid[J]. Journal of Pharmaceutical Practice and Service, 2022, 40(2): 103-107, 131. doi: 10.12206/j.issn.1006-0111.202108002
Citation: LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
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