Chemical constituents and pharmacological activities of <i>Carthamus tinctorius</i> L.

HU Xiao-jia; YIN Sha; YUAN Ting-ting; WANG Yu-Jue; HUANG Zhen-ru; LU Yang

doi:10.3969/j.issn.1006-0111.2013.03.001

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Volume 31 Issue 3

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(3): 161-168,197

HU Xiao-jia, YIN Sha, YUAN Ting-ting, WANG Yu-Jue, HUANG Zhen-ru, LU Yang. Chemical constituents and pharmacological activities of Carthamus tinctorius L.[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 161-168,197. doi: 10.3969/j.issn.1006-0111.2013.03.001

Citation:

HU Xiao-jia, YIN Sha, YUAN Ting-ting, WANG Yu-Jue, HUANG Zhen-ru, LU Yang. Chemical constituents and pharmacological activities of Carthamus tinctorius L.[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 161-168,197. doi: 10.3969/j.issn.1006-0111.2013.03.001

Chemical constituents and pharmacological activities of Carthamus tinctorius L.

doi: 10.3969/j.issn.1006-0111.2013.03.001

1.
School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
2.
School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China

Received Date: 2012-09-12
Rev Recd Date: 2012-11-19

Abstract

Safflower(Carthamus tinctorius L.), a traditional Chinese medicine, belongs to Carthamus genus (Asteraceae). Previous studies revealed that safflower contains flavonoids, serotonins, polyacetylenes, spermidines, mataresinols, sesquiterpenes, steroids, and so on. Quinone chalcones were found in safflower which occurred in few other plants. Various bio-actives of Safflower had been confirmed by modern pharmacology, such as cardiovascular, nervous system, immune system, and so on. The progress of its chemical constituents and pharmacological activities was reviewed which provided references for further study.
- Carthamus tinctorius L.,
- chemical constitunets,
- pharmacological activities,
- quinochalcone,
- Asteraceae

References

[1]	中国植物志[M]. 北京:科学出版社. 1983, 78(1):186.
[2]	江苏新医学院. 中药大词典[M]. 上海:上海科技出版社. 1986:992.
[3]	李艳梅, 车庆明. 红花化学成分的研究[J]. 药学学报, 1998, 33(8):626
[4]	Masao H, Huang XL, Che QM, et al. 6-hydroxykaempferol and its glycosides from Carthamus tinctorius petals[J]. Phytochem, 1992, 31(11):4001.
[5]	Li F, He ZS, Ye Y. Flavonoids from Carthamus tinctorius[J].Chin J Chem, 2002, 20:699.
[6]	范莉, 赵海誉, 濮润, 等. 红花的黄酮类化学成分研究[J]. 中国药学杂志, 2011, 46(5):333.
[7]	Kazuma K, Kahashi T, Sato K, et al. Quinochalcones and flavonoids from fresh florets indifferent cultivars of Carthamus tinctorius L[J]. Biosci Biotechnol Biochem, 2000, 64(8):1588.
[8]	姜建双. 红花化学成分及生物活性研究[D]. 北京:北京协和医学院博士论文, 2008.
[9]	Ahmed KM, Marzouk MS, El-Khrisy EAM, et al. A new flavone diglycoside from Carthamus tinctorius seeds[J]. Pharmazie, 2000, 55(8):621.
[10]	Novruzov EN, Shamsizade LA. Anthocyanins of Carthamus species.Chem Nat Compd[J]. 1998, 34(4):514.
[11]	Zhou YZh, Chen H, Qiao L, et al. Two new compounds from Carthamus tinctorius[J]. J Asian Nal Prod Res, 2008, 10(5):429.
[12]	魏海关. 含乙酰谷酰胺和红花有效成分的药物组合物及其制剂[P]. 中国专利 2007, 18(11):2854.
[13]	Yin HB, He ZS. A novel semi-quione chalcone sharing a pyrrole ring C-glycoside from Carthamus tinctorius[J]. Tetra Lett, 2000, 41:1955.
[14]	Jiang JS, He J, Feng ZM, et al. Two new quinochalcones from the florets of Carthamus tinctorius[J]. Organic Lett, 2010, 12(6):1196.
[15]	Meslhy MR, Kadota S, Momose Y, et al. Tinctormine, a nove Ca²⁺ antagonist N-contaning quinochalcone C-glycoside from Carthamus tinctorius L[J]. Chem Pharm Bull, 1992, 40(12):3355.
[16]	Zhang HL,Akito N,Toshihiro W,et al.Antioxidative compounds isolated from safflower(Carthamus tinctorius L.)oil cake[J].Chem Pharm Bull,1997,45(2):1910.
[17]	Hiroji S,Hirokazu K,Tsutomu N,et al.Serotobenine,a novel phenolic amide from safflower seeds(Carthamus tinctorius L.)[J].Agri Biol Chem,1985,49(10):2969.
[18]	郑虎占, 懂泽宏, 佘靖. 中药现代化研究与应用第3卷[M]. 北京:学苑出版社, 1998:2057.
[19]	刘玉明, 杨峻山, 刘庆华. 红花化学成分研究[J]. 中药材, 2005, 4(28):288.
[20]	郝军, 李福双, 刘照振, 等. 红花中的多烯炔类化学成分[C]. 2010年中国药学大会暨第十届中国药师周论文集, 天津, 中国药学会, 2010.
[21]	Zhou YZ, Ma HY, Chen H, et al. New acetylenic glucosides from Carthamus tinctorius[J]. Chem Pharm Bull, 2006, 54(10):1455.
[22]	Jiang JS, Lv L, Yang YJ, et al. New spermidines from the florets of Carthamus tinctorius[J]. J Asian Nat Prod Res, 2008, 10(5):447.
[23]	Zhao G, Qin GW, Gai Y, et al. Structural identification of a new tri-p-coumaroylspermidine with serotonin transporter inhibition from safflower[J]. Chem Pharm Bull, 2010, 58(7):950.
[24]	Yoo HH, Park JH, Kwon SW. An anti-estrogenic lignan glycoside, racheloside, from seeds of Carthamus tinctorius[J]. Biosci Biotechnol Biochem, 2006, 70(11):2783.
[25]	Akito N, Hui LZ, Toshihiro W, et al. New steroid and matairesinol glycosides from safflower(Carthamus tinctorius L.) oil cake[J]. Chem Pharm Bull. 1998, 46(6):1044.
[26]	周玉枝, 陈欢, 乔莉, 等. 红花化学成分研究[J]. 中国药物化学杂志, 2007, 17(6):380
[27]	姜建双, 夏鹏飞, 冯子明, 等. 红花化学成分研究[J]. 中国中药杂志, 2008, 33(24):2911.
[28]	常海涛, 韩宏星, 屠鹏飞.中药红花化学成份及药理作用[J]. 国外医药:植物药分册, 1999, 14(5):201.
[29]	周震, 李娟, 周传德. 红花油脂肪酸的质谱分析[J]. 中成药, 1995, 17(6):35.
[30]	Toshihiro A, Hirotoshi O, Toshitake T, et al. Erytho-hentriacon-tane-6, 8-diol and 11 other alkance 6, 8-diols from Carthamus tinctorius[J]. Phytochem, 1994, 369(1):105
[31]	霍贤, 梁忠岩, 张雅君, 等. 红花水溶性多糖的分离、纯化及初步研究[J]. 中国药学杂志, 2005, 40(8):620.
[32]	李锋, 何直, 叶阳. 红花中核黄素及其降解产物[J]. 中草药, 2004, 35(3):247.
[33]	高其铭.中药红花的药理研究概况[J]. 中西医结合杂志, 1984, 4(12):758.
[34]	李世英, 时德, 吴凯. 红花对周围血管作用的初步研究——动物离体器官实验[J]. 中华医学杂志, 1979, 59(9):550.
[35]	鲍善芬, 崔凯荣, 赵淑芸. 红花油对小鼠实验性高胆固醇血症影响的初步实验[J]. 药学通报, 1984, 19(5):59.
[36]	柏蕙英, 秦月琴. 红花对脑减压缺氧缺血幼鼠脑神经元的保护作用[J]. 中草药, 1992, 23(10):531.
[37]	欧芹, 魏晓东, 孙鹏, 等. 红花黄色素对衰老模型小鼠脑细胞凋亡的影响[J]. 中国康复医学杂志, 2006, 21(6):504.
[38]	邱莉. 红花黄色素对新生大鼠缺氧缺血性脑病的保护作用[D]. 福建:福建医科大学硕士论文, 2009.
[39]	逯素梅. 羟基红花黄色素A抗谷氨酸氧化性神经损伤的保护作用[D]. 山东:山东大学硕士论文, 2008.
[40]	夏玉叶, 闵旸, 盛雨辰. 羟基红花黄色素A对大鼠脑缺血损伤的神经保护作用[J]. 中国医药工业杂志, 2005, 36(12):760.
[41]	彭其胜. 红花注射液对大鼠周围神经缺血再灌注损伤的保护作用及其机制研究[J]. 中国药房, 2011,22(23):2139.
[42]	林山. 红花注射液对脊髓缺血再灌注损伤早期作用及机制的实验研究[D]. 福建中医学院硕士论文, 2007:28.
[43]	王晓菲, 金鸣. 红花抗炎作用机制研究进展[J]. 山西医药杂志, 2007, 36(1):51.
[44]	程健祥, 朱作金, 梁纲, 等. 川芎嗪、红花对免疫功能的影响[J]. 实用中西医结合杂志. 1993, 6(5):261.
[45]	黄虹, 俞曼雷, 翟世康, 等. 红花多糖的免疫活性研究[J]. 中草药, 1984, 15(4):21.
[46]	舒畅, 张延英, 蔺兴遥, 等. 红花凝胶剂抗炎镇痛作用的实验研究[J]. 中国实验方剂学杂志, 2009, 15(1):72.
[47]	陈文梅, 金鸣, 吴伟, 等. 红花黄酮成分抑制血小板激活因子介导的血小板活化作用[J]. 药学学报, 2001, 36(12):881.
[48]	侯家玉. 中药药理学[M]. 北京:中国中医药出版社, 2002, 159.
[49]	Kasahars Y, Kumaki K, Katagiri S, et al. Carthami flos extract and its components stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis[J]. Phytother Res, 1994, 8:327.
[50]	安川宪. 红花的抑癌作用[A]. 第10次天然药物的开发与应用学术讨论会论文集, 1995:467.
[51]	徐国钧, 王强, 余伯阳, 等. 抗肿瘤中草药彩色图谱[M]. 福州:福建科学技术出版社, 2000:368.
[52]	凌均, 樊明文, 魏国贤. 植物化学抑制变形链球菌附着的实验研究[J]. 华西口腔医学杂志, 1989, 7(4):217.
[53]	赵永娜, 蒋家雄. 三种活血化瘀药对四氯化碳损伤离体大鼠灌流肝作用的研究[J]. 中医药研究. 1997, 13(4):43.
[54]	张诗平, 徐传福. 红花的临床应用进展概况[J]. 中国中药杂志, 1997, 22(7):439.

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Chemical constituents and pharmacological activities of Carthamus tinctorius L.

1. School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

2. School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China

Received Date: 2012-09-12

Rev Recd Date: 2012-11-19

Key words:

Abstract: Safflower(Carthamus tinctorius L.), a traditional Chinese medicine, belongs to Carthamus genus (Asteraceae). Previous studies revealed that safflower contains flavonoids, serotonins, polyacetylenes, spermidines, mataresinols, sesquiterpenes, steroids, and so on. Quinone chalcones were found in safflower which occurred in few other plants. Various bio-actives of Safflower had been confirmed by modern pharmacology, such as cardiovascular, nervous system, immune system, and so on. The progress of its chemical constituents and pharmacological activities was reviewed which provided references for further study.

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Reference (54)

[1]	中国植物志[M]. 北京:科学出版社. 1983, 78(1):186.
[2]	江苏新医学院. 中药大词典[M]. 上海:上海科技出版社. 1986:992.
[3]	李艳梅, 车庆明. 红花化学成分的研究[J]. 药学学报, 1998, 33(8):626
[4]	Masao H, Huang XL, Che QM, et al. 6-hydroxykaempferol and its glycosides from Carthamus tinctorius petals[J]. Phytochem, 1992, 31(11):4001.
[5]	Li F, He ZS, Ye Y. Flavonoids from Carthamus tinctorius[J].Chin J Chem, 2002, 20:699.
[6]	范莉, 赵海誉, 濮润, 等. 红花的黄酮类化学成分研究[J]. 中国药学杂志, 2011, 46(5):333.
[7]	Kazuma K, Kahashi T, Sato K, et al. Quinochalcones and flavonoids from fresh florets indifferent cultivars of Carthamus tinctorius L[J]. Biosci Biotechnol Biochem, 2000, 64(8):1588.
[8]	姜建双. 红花化学成分及生物活性研究[D]. 北京:北京协和医学院博士论文, 2008.
[9]	Ahmed KM, Marzouk MS, El-Khrisy EAM, et al. A new flavone diglycoside from Carthamus tinctorius seeds[J]. Pharmazie, 2000, 55(8):621.
[10]	Novruzov EN, Shamsizade LA. Anthocyanins of Carthamus species.Chem Nat Compd[J]. 1998, 34(4):514.
[11]	Zhou YZh, Chen H, Qiao L, et al. Two new compounds from Carthamus tinctorius[J]. J Asian Nal Prod Res, 2008, 10(5):429.
[12]	魏海关. 含乙酰谷酰胺和红花有效成分的药物组合物及其制剂[P]. 中国专利 2007, 18(11):2854.
[13]	Yin HB, He ZS. A novel semi-quione chalcone sharing a pyrrole ring C-glycoside from Carthamus tinctorius[J]. Tetra Lett, 2000, 41:1955.
[14]	Jiang JS, He J, Feng ZM, et al. Two new quinochalcones from the florets of Carthamus tinctorius[J]. Organic Lett, 2010, 12(6):1196.
[15]	Meslhy MR, Kadota S, Momose Y, et al. Tinctormine, a nove Ca²⁺ antagonist N-contaning quinochalcone C-glycoside from Carthamus tinctorius L[J]. Chem Pharm Bull, 1992, 40(12):3355.
[16]	Zhang HL,Akito N,Toshihiro W,et al.Antioxidative compounds isolated from safflower(Carthamus tinctorius L.)oil cake[J].Chem Pharm Bull,1997,45(2):1910.
[17]	Hiroji S,Hirokazu K,Tsutomu N,et al.Serotobenine,a novel phenolic amide from safflower seeds(Carthamus tinctorius L.)[J].Agri Biol Chem,1985,49(10):2969.
[18]	郑虎占, 懂泽宏, 佘靖. 中药现代化研究与应用第3卷[M]. 北京:学苑出版社, 1998:2057.
[19]	刘玉明, 杨峻山, 刘庆华. 红花化学成分研究[J]. 中药材, 2005, 4(28):288.
[20]	郝军, 李福双, 刘照振, 等. 红花中的多烯炔类化学成分[C]. 2010年中国药学大会暨第十届中国药师周论文集, 天津, 中国药学会, 2010.
[21]	Zhou YZ, Ma HY, Chen H, et al. New acetylenic glucosides from Carthamus tinctorius[J]. Chem Pharm Bull, 2006, 54(10):1455.
[22]	Jiang JS, Lv L, Yang YJ, et al. New spermidines from the florets of Carthamus tinctorius[J]. J Asian Nat Prod Res, 2008, 10(5):447.
[23]	Zhao G, Qin GW, Gai Y, et al. Structural identification of a new tri-p-coumaroylspermidine with serotonin transporter inhibition from safflower[J]. Chem Pharm Bull, 2010, 58(7):950.
[24]	Yoo HH, Park JH, Kwon SW. An anti-estrogenic lignan glycoside, racheloside, from seeds of Carthamus tinctorius[J]. Biosci Biotechnol Biochem, 2006, 70(11):2783.
[25]	Akito N, Hui LZ, Toshihiro W, et al. New steroid and matairesinol glycosides from safflower(Carthamus tinctorius L.) oil cake[J]. Chem Pharm Bull. 1998, 46(6):1044.
[26]	周玉枝, 陈欢, 乔莉, 等. 红花化学成分研究[J]. 中国药物化学杂志, 2007, 17(6):380
[27]	姜建双, 夏鹏飞, 冯子明, 等. 红花化学成分研究[J]. 中国中药杂志, 2008, 33(24):2911.
[28]	常海涛, 韩宏星, 屠鹏飞.中药红花化学成份及药理作用[J]. 国外医药:植物药分册, 1999, 14(5):201.
[29]	周震, 李娟, 周传德. 红花油脂肪酸的质谱分析[J]. 中成药, 1995, 17(6):35.
[30]	Toshihiro A, Hirotoshi O, Toshitake T, et al. Erytho-hentriacon-tane-6, 8-diol and 11 other alkance 6, 8-diols from Carthamus tinctorius[J]. Phytochem, 1994, 369(1):105
[31]	霍贤, 梁忠岩, 张雅君, 等. 红花水溶性多糖的分离、纯化及初步研究[J]. 中国药学杂志, 2005, 40(8):620.
[32]	李锋, 何直, 叶阳. 红花中核黄素及其降解产物[J]. 中草药, 2004, 35(3):247.
[33]	高其铭.中药红花的药理研究概况[J]. 中西医结合杂志, 1984, 4(12):758.
[34]	李世英, 时德, 吴凯. 红花对周围血管作用的初步研究——动物离体器官实验[J]. 中华医学杂志, 1979, 59(9):550.
[35]	鲍善芬, 崔凯荣, 赵淑芸. 红花油对小鼠实验性高胆固醇血症影响的初步实验[J]. 药学通报, 1984, 19(5):59.
[36]	柏蕙英, 秦月琴. 红花对脑减压缺氧缺血幼鼠脑神经元的保护作用[J]. 中草药, 1992, 23(10):531.
[37]	欧芹, 魏晓东, 孙鹏, 等. 红花黄色素对衰老模型小鼠脑细胞凋亡的影响[J]. 中国康复医学杂志, 2006, 21(6):504.
[38]	邱莉. 红花黄色素对新生大鼠缺氧缺血性脑病的保护作用[D]. 福建:福建医科大学硕士论文, 2009.
[39]	逯素梅. 羟基红花黄色素A抗谷氨酸氧化性神经损伤的保护作用[D]. 山东:山东大学硕士论文, 2008.
[40]	夏玉叶, 闵旸, 盛雨辰. 羟基红花黄色素A对大鼠脑缺血损伤的神经保护作用[J]. 中国医药工业杂志, 2005, 36(12):760.
[41]	彭其胜. 红花注射液对大鼠周围神经缺血再灌注损伤的保护作用及其机制研究[J]. 中国药房, 2011,22(23):2139.
[42]	林山. 红花注射液对脊髓缺血再灌注损伤早期作用及机制的实验研究[D]. 福建中医学院硕士论文, 2007:28.
[43]	王晓菲, 金鸣. 红花抗炎作用机制研究进展[J]. 山西医药杂志, 2007, 36(1):51.
[44]	程健祥, 朱作金, 梁纲, 等. 川芎嗪、红花对免疫功能的影响[J]. 实用中西医结合杂志. 1993, 6(5):261.
[45]	黄虹, 俞曼雷, 翟世康, 等. 红花多糖的免疫活性研究[J]. 中草药, 1984, 15(4):21.
[46]	舒畅, 张延英, 蔺兴遥, 等. 红花凝胶剂抗炎镇痛作用的实验研究[J]. 中国实验方剂学杂志, 2009, 15(1):72.
[47]	陈文梅, 金鸣, 吴伟, 等. 红花黄酮成分抑制血小板激活因子介导的血小板活化作用[J]. 药学学报, 2001, 36(12):881.
[48]	侯家玉. 中药药理学[M]. 北京:中国中医药出版社, 2002, 159.
[49]	Kasahars Y, Kumaki K, Katagiri S, et al. Carthami flos extract and its components stigmasterol, inhibit tumor promotion in mouse skin two-stage carcinogenesis[J]. Phytother Res, 1994, 8:327.
[50]	安川宪. 红花的抑癌作用[A]. 第10次天然药物的开发与应用学术讨论会论文集, 1995:467.
[51]	徐国钧, 王强, 余伯阳, 等. 抗肿瘤中草药彩色图谱[M]. 福州:福建科学技术出版社, 2000:368.
[52]	凌均, 樊明文, 魏国贤. 植物化学抑制变形链球菌附着的实验研究[J]. 华西口腔医学杂志, 1989, 7(4):217.
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Chemical constituents and pharmacological activities of Carthamus tinctorius L.

doi: 10.3969/j.issn.1006-0111.2013.03.001

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Chemical constituents and pharmacological activities of Carthamus tinctorius L.

doi: 10.3969/j.issn.1006-0111.2013.03.001

1. School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

2. School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China

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Chemical constituents and pharmacological activities of Carthamus tinctorius L.

doi: 10.3969/j.issn.1006-0111.2013.03.001

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通讯作者: 陈斌, bchen63@163.com

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Chemical constituents and pharmacological activities of Carthamus tinctorius L.

doi: 10.3969/j.issn.1006-0111.2013.03.001

1. School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China 2. School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China

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1. School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China

2. School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China