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Volume 31 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(3): 217-219

DUAN Shen-fu, SHI Jun-fei. Study on molding technology of Bulleyaconitine A dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 217-219. doi: 10.3969/j.issn.1006-0111.2013.03.017
Citation: DUAN Shen-fu, SHI Jun-fei. Study on molding technology of Bulleyaconitine A dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 217-219. doi: 10.3969/j.issn.1006-0111.2013.03.017
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Study on molding technology of Bulleyaconitine A dropping pill

doi: 10.3969/j.issn.1006-0111.2013.03.017

  • Department of Pharmacy, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010030, China

  • Received Date: 2012-07-19
  • Rev Recd Date: 2012-10-19
  • Objective To establish the optimized molding technology of Bulleyaconitine A dropping pills. Methods The optimum extraction process was selected with orthogonal experiment, difference of pill mass, dissolution-time and quality difference coefficient of pill were taken as indicators. Through examination, the ratio of drug to matrix, mixture temperature, dropping speed and the external diameter of burette were selected as the best dropping conditions. Results The best dropping conditions were that the ratio of drug to matrix was 1:6:1.5~1:8:2, the mixture temperature was (80±1)℃, the dropping speed was 50 drops per minute, and the external diameter of burette was 1.32/2.28 mm. Conclusion The molding technology of Bulleyaconitine A dropping pills was a very simple, feasible, stable and high-achievement ratio.
  • [1] 中国药典2010版. 二部[S]. 2010:373.
    [2] 张源潮,杨清锐,尹宏恩,等.草乌甲素治疗骨关节炎及类风湿性关节炎临床观察[J].中药药理与临床, 2000:16(2):43.
    [3] Xiong X, Zhai S. Sensitive quantification of bulleyaconitine A in human serum by liquid chromatography-tandem mass spectrometry[J]. Biosci Biotechnol Biochem, 2009:73(7):1572.
    [4] 李春花,王丽萍,高艳芝,等.连贞滴丸的成型工艺研究[J]. 中国医院药学杂志, 2008:28(8):631.
    [5] 林华庆,张 蜀,邓 红.正交试验法优选雪胆素滴丸的成型工艺[J]. 广东药学院学报, 2006:22(1):4.
    [6] 黄贤惠, 邢建国, 王新春, 等. 正交设计法优选天山雪莲凝胶剂基质处方[J]. 中国中药杂志, 2010:35(14):1803.
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Study on molding technology of Bulleyaconitine A dropping pill

doi: 10.3969/j.issn.1006-0111.2013.03.017
  • Department of Pharmacy, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010030, China
  • Received Date: 2012-07-19
  • Rev Recd Date: 2012-10-19

Abstract: Objective To establish the optimized molding technology of Bulleyaconitine A dropping pills. Methods The optimum extraction process was selected with orthogonal experiment, difference of pill mass, dissolution-time and quality difference coefficient of pill were taken as indicators. Through examination, the ratio of drug to matrix, mixture temperature, dropping speed and the external diameter of burette were selected as the best dropping conditions. Results The best dropping conditions were that the ratio of drug to matrix was 1:6:1.5~1:8:2, the mixture temperature was (80±1)℃, the dropping speed was 50 drops per minute, and the external diameter of burette was 1.32/2.28 mm. Conclusion The molding technology of Bulleyaconitine A dropping pills was a very simple, feasible, stable and high-achievement ratio.

DUAN Shen-fu, SHI Jun-fei. Study on molding technology of Bulleyaconitine A dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 217-219. doi: 10.3969/j.issn.1006-0111.2013.03.017
Citation: DUAN Shen-fu, SHI Jun-fei. Study on molding technology of Bulleyaconitine A dropping pill[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 217-219. doi: 10.3969/j.issn.1006-0111.2013.03.017
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