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Volume 31 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(3): 220-223

BI Ya-jing, WANG Yang-ping, LIU Fu-qiang, ZHAO Nan, LIU Dan, HAN Dan, LIU Tian-jiao. Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 220-223. doi: 10.3969/j.issn.1006-0111.2013.03.018
Citation: BI Ya-jing, WANG Yang-ping, LIU Fu-qiang, ZHAO Nan, LIU Dan, HAN Dan, LIU Tian-jiao. Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 220-223. doi: 10.3969/j.issn.1006-0111.2013.03.018
shu

Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide

doi: 10.3969/j.issn.1006-0111.2013.03.018
  • 1.

    School of Pharmacy, Yan Bian University, Yanji 133000, China;The 208th Hospital of PLA, Changchun 130062, China

  • 2.

    The 208th Hospital of PLA, Changchun 130062, China

  • 3.

    School of Pharmacy, Yan Bian University, Yanji 133000, China

  • Received Date: 2012-12-26
  • Rev Recd Date: 2013-05-01
  • Objective To determination the molecular weight and studies on its properties after hydrophobic modification of Bletilla striata polysaccharide. Methods Bletilla striata polysaccharide were used as the starting materials, which reacted with cholesterol succinate to afford a derivate of cholesterol succinate polysaccharide, characterizate its structure by infrared spectroscopy, determinate its molecular weight by Sephadex chromatography(HPGPC). Results Acholesterol succinate polysaccharide was synthesized:molecular weight 650 kDa, pH 6.89, viscosity 130 mpa, isoelectric point 5.07, solubilit 0.9 g. Conclusion The method of synthesis was feasible and stable, which provided valuable research base for expand test.
  • [1] 刘逢芹,夏丽娅.中药白芨的现代研究概况[J].山东医药工业,2000,19(5):32.
    [2] Wang QP,Zhang DH.The characters of Blelitta striata Reichb.f.and its potential potential developing vaines[J].Resecrce Development&Market,2000,16(4):216.
    [3] 江 倩,王银松. 新型两亲性小分子-N-胆甾醇基琥珀酰基氨基葡萄糖的合成及其自组装行为的初步研究[J].国际生物医学工程,2009,32(3):142.
    [4] 韩 笑,谭天伟.羧甲基壳聚糖制备新工艺研究[N].北京化工大学学报.2000,27(3):1.
    [5] Rong HC.Conformational changes of chitosan molecules and the shift of break point of Mark Houwink equation by increasing urea concentration[J].Appl Polym Sci,2000,75(4):452.
    [6] 中国药典2010年版二部[S].2010:附录42.
    [7] Skiyoshi K, Sunamoto J.Supramolecular assembly of hydrophobized polysaccharides[J].Supramol Sci,1996,3(4):157.
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Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide

doi: 10.3969/j.issn.1006-0111.2013.03.018
  • 1. School of Pharmacy, Yan Bian University, Yanji 133000, China;The 208th Hospital of PLA, Changchun 130062, China
  • 2. The 208th Hospital of PLA, Changchun 130062, China
  • 3. School of Pharmacy, Yan Bian University, Yanji 133000, China
  • Received Date: 2012-12-26
  • Rev Recd Date: 2013-05-01

Abstract: Objective To determination the molecular weight and studies on its properties after hydrophobic modification of Bletilla striata polysaccharide. Methods Bletilla striata polysaccharide were used as the starting materials, which reacted with cholesterol succinate to afford a derivate of cholesterol succinate polysaccharide, characterizate its structure by infrared spectroscopy, determinate its molecular weight by Sephadex chromatography(HPGPC). Results Acholesterol succinate polysaccharide was synthesized:molecular weight 650 kDa, pH 6.89, viscosity 130 mpa, isoelectric point 5.07, solubilit 0.9 g. Conclusion The method of synthesis was feasible and stable, which provided valuable research base for expand test.

BI Ya-jing, WANG Yang-ping, LIU Fu-qiang, ZHAO Nan, LIU Dan, HAN Dan, LIU Tian-jiao. Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 220-223. doi: 10.3969/j.issn.1006-0111.2013.03.018
Citation: BI Ya-jing, WANG Yang-ping, LIU Fu-qiang, ZHAO Nan, LIU Dan, HAN Dan, LIU Tian-jiao. Preparation and physical chemistry properties research of cholesterol succinyl Bletilla striata polysaccharide[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 220-223. doi: 10.3969/j.issn.1006-0111.2013.03.018
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