Modern research on compatibility mechanism of Chinese medicinal formula

CHANG Wan-lin; HUANG Hui-mei; HAN Lin; LI Min; JIANG Peng; LIU Run-hui

doi:10.3969/j.issn.1006-0111.2013.06.002

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Chinese medicinal formula was the main form of Chinese clinical medicine. The compatibility mechanism was an important part of the modernization of Traditional Chinese Medicine. The study of Chinese medicine compound compatibility mechanism explored the relationship between the formula compatibility, the changes of material basis and pharmacological effects and pharmacokinetics from pharmacology and chemistry aspects. The basic characteristics of compatibility mechanism of Chinese medicinal formula, modern research ideas and methods were reviewed in this paper.

Modern research on compatibility mechanism of Chinese medicinal formula

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-08-22

Rev Recd Date: 2013-04-17

Key words:

Chinese medicinal formula /
compatibility mechanism

Abstract: Chinese medicinal formula was the main form of Chinese clinical medicine. The compatibility mechanism was an important part of the modernization of Traditional Chinese Medicine. The study of Chinese medicine compound compatibility mechanism explored the relationship between the formula compatibility, the changes of material basis and pharmacological effects and pharmacokinetics from pharmacology and chemistry aspects. The basic characteristics of compatibility mechanism of Chinese medicinal formula, modern research ideas and methods were reviewed in this paper.

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Reference (32)

[1]	路晓钦,高月.中药复方现代化药理研究方法进展[J].中药新药与临床理,2002,13(1):59.
[2]	曾苏.药物代谢学[M].杭州:浙江大学出版社,2008:282.
[3]	袁久荣,袁浩.中药配伍与化学关系论[J].中国中医药信息杂志,1998,5(8):8.
[4]	潘锋.在分子水平阐明中药复方作用机制是完全可能的[N].科学时报,2008-04-15.
[5]	曾桂凤.复方丹参配伍的化学物质基础和药理研究[D].大连:中国科学院研究生院(大连化学物理研究所),2006.
[6]	杨文宇,万德光,杨鑫嵎.虚拟筛选辅助揭示中药药效物质基础的思路与初步实践[J].中草药,2011,42(9):1665.
[7]	Burbaum JJ,Sigal NH.New technologies for high-throughput screening[J].Curr Opin Chem Biol,1997,1(1):72.
[8]	杜冠华.药物筛选新技术与中药现代化研究[J].世界科学技术,2000,2(4):47.
[9]	李洪林,沈建华,罗小民,等.虚拟筛选与新药发现[J].生命科学,2005,17(2):125.
[10]	杜冠华.高通量药物筛选在新药研究中的应用[J].基础医学与临床2001,21(4):289.
[11]	杨奎,郭力,周明眉,等.中药复方组合化学研究方法初探[J].中药药理与临床,1998,14(3):42.
[12]	何敏,沈敏,周家驹.中药数据库的设计与建立[J].计算机与应用化学,1999,16(5):363.
[13]	Stone R.Biochemistry.Lifting the veil on traditional Chinese medicine[J].Science,2008,319(5864):709.
[14]	王月华,张海霞,李奇,等.小续命汤有效成分组的高通量筛选研究[J].中西医结合学报,2006,4(1):64.
[15]	张丹参,张天泰,杜冠华.均匀设计-高通量筛选技术在中药丹参多成分配比研究中的应用[J]. 中国药学杂志,2009,44(14):1048.
[16]	于卫江,黄丽军,朱大岭.应用大鼠肝微粒体筛选对细胞色素P4502D6有抑制作用的中药[J]. 中草药,2007,38(3):397.
[17]	匡学海.中药化学[M].北京:中国中医药出版社,2003:415.
[18]	罗国安,梁琼麟,张荣利.化学物质组学与中药方剂研究—兼析清开灵复方物质基础研究[J].世界科学技术:中医药现代化,2006,8(1):6.
[19]	罗国安,梁琼麟,刘清飞,等.整合化学物质组学的整体系统生物学—中药复方配伍和作用机理研究的整体方法论[J].世界科学技术-中医药现代化,2007,9(1):10.
[20]	翁小刚,李玉洁,杨庆,等.戊己丸不同配伍组方体内对CYP1A2酶活性的影响研究及其临床意义[J]. 世界科学技术-中医药现代化,2011,13(1):193.
[21]	孙健,温庆辉, 李夏,等.黄连解毒汤及其含药血清的化学成分及抗肿瘤作用对比研究[J].中国中药杂志, 2006, 31(18):1526.
[22]	韩笑.中药有效组分配伍方剂对心肌缺血再灌注性损伤的干预机制[D].北京:中国中医研究院,2005.
[23]	束云,李连达.药代动力学-药效动力学结合模型在中药研究中的应用[J].中国药理学通报,2008,24(11):1405.
[24]	赵玉男,邢东明,丁怡.解热复方YL2000的药代动力学研究[J].中国药理学通报,2004,20(7):776.
[25]	冯年平,都广礼,狄斌,等.试论中药方剂配伍—代谢关系[J].上海中医药杂志,2007,41(10):6.
[26]	任平,黄熙,李双庆,等.加味逍遥散对功能性消化不良肝郁脾虚型患者胃电图及阿魏酸药动学特征的影响[J].中国中西医结合杂志,2006,26(5):398.
[27]	单玉.苦参、黄芪药对配伍对病毒性心肌炎的治疗作用及机制研究[D].沈阳:辽宁中医药大学,2010.
[28]	Lindon JC, Holmes E, Nicholson JK.So what's the deal with metabonomics[J]. Anal Chem, 2003, 75(17):384.
[29]	王喜军,张伯礼.基于药物代谢组学的方剂配伍规律及配伍科学价值揭示[J].中国中药杂志,2010,35(10):1346.
[30]	武斌,曹敏,于海龙,等.基于代谢组学的苍耳子配伍黄芪后减毒作用研究[J].中中药药理与临床,2012,28(2):98.
[31]	黄召谊.交泰丸的药代动力学及其治疗2型糖尿病的代谢组学研究[D].武汉:华中科技大学,2011.
[32]	Wang L, Zhou GB, Liu P, et al.Dissection of mechanisms of Chinese medicinal formula Realgar-Indigo naturalis as an effective treatment for promyelocytic leukemia[J].Proc Natl Acad Sci USA,2008,105(12):4826.

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Modern research on compatibility mechanism of Chinese medicinal formula

doi: 10.3969/j.issn.1006-0111.2013.06.002

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