Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds

WEI Hai-yang; LIU Na; ZHOU You-jun; LV Jia-guo; ZHU Ju

doi:10.3969/j.issn.1006-0111.2013.06.013

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Volume 31 Issue 6

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2013 > 31(6): 446-447,469

WEI Hai-yang, LIU Na, ZHOU You-jun, LV Jia-guo, ZHU Ju. Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 446-447,469. doi: 10.3969/j.issn.1006-0111.2013.06.013

Citation:

WEI Hai-yang, LIU Na, ZHOU You-jun, LV Jia-guo, ZHU Ju. Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 446-447,469. doi: 10.3969/j.issn.1006-0111.2013.06.013

Synthesis of 2-substitudephenoxy-5-benzyloxypyrimidines compounds

doi: 10.3969/j.issn.1006-0111.2013.06.013

1.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Sinch Pharmaceuticals Tech. Co., Ltd, Shanghai 200232, China
2.
Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2012-10-24
Rev Recd Date: 2013-04-25

Abstract

Objective To prepare 2-substitudephenoxy-5-benzyloxypyrimidines and 2-substitudephenoxy-5-hydroxypyrimidines which had not been reported. Methods The target compounds were prepared from 2-chlorine-5-hydroxypyrimidine through hydroxy protection, Williamsom reaction and reduction of benzyl group. Results The synthetic process provided a simple, easy diposal procedure and high overall yield. Fourteen new phenoxy pyrimidines compounds were prepared. Conclusions It was a new synthetic method which was easy to operate with moderate reaction conditions.
- 2-substitudephenoxy-5-benzyloxypyrimidines,
- 2-substitudephenoxy-5-hydroxypyrimidines,
- synthesis

References

[1]	Zoller G,Schmoll D,Mueller M,et al. Heterocyclic compounds, processes for their preparation, medicaments comprising these compounds, and the use thereof[P].WO,2010003624,2010-01-14.
[2]	Okada H,Koyanagi T,Yamada N,et al.Synthesis and anxiolytic activity of N-substituted cyclic imides (1R^,2S^3R^,4S^)-N-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]--2,3-bicyclo[2.2.1] heptanedicarboximide(Tandospirone) and related compounds[J].Chem Pharm Bull,1991,39:1308.
[3]	Susheel JN,Mukund J,Johan B,et al.A simple Cu-catalyzed coupling approach to substituted 3-Pyridinol and 5-Pyrimidinol antioxidants[J].J Org Chem, 2008,73(23):9326.
[4]	Chapman D,Gabos B,Munck RM,et al.Preparation of hydantoin derivatives for use as MMP inhibitors[P].WO,2008065393,2008-06-05.

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1.
沈阳化工大学材料科学与工程学院沈阳 110142

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