Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage

LI Jianying

doi:10.3969/j.issn.1006-0111.2014.01.018

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Objective To study the clinical effect of mifepristone combined with misoprostol and misoprostol in missed abortion curettage. Methods Seventy cases from April 2010 to August 2011 of medical termination of pregnancy in Huzhou family planning service station of Zhejiang Province were collected. All cases were divided randomly into research group (38 cases) and the control group (32 cases). The patients in research group were treated with mifepristone 50 mg once per 12 h, 3 times, on 3rd day, 600 μg misoprostol 2 h before abortion curettage; the patients in control group were treated with 600 μg misoprostol 2 h before abortion curettage. Results There was no significant difference between the 2 groups in complete abortion rate (P>0.05). Vaginal bleeding time in research group was significantly less than that in control group, there was significant difference between 2 groups, with χ²=4.12 and P<0.05. Blood volume in research group was significantly less than in control group, there was significant difference between the 2 groups, with χ²=5.30, and P<0.05.The incidence of side effects of research group was significantly less than that of control group, there was significant difference between 2 groups, with χ²=5.61 and P<0.05. Conclusion Mifepristone combined with misoprostol and misoprostol only for pregnancy termination had the same clinical effect. But mifepristone combined with misoprostol could effectively reduce the vaginal bleeding time and blood loss, and have fewer side effects.

Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage

Huzhou Family Planning Service Station of Zhejiang Province, Huzhou 313000, China

Received Date: 2013-05-22

Rev Recd Date: 2013-10-17

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Abstract: Objective To study the clinical effect of mifepristone combined with misoprostol and misoprostol in missed abortion curettage. Methods Seventy cases from April 2010 to August 2011 of medical termination of pregnancy in Huzhou family planning service station of Zhejiang Province were collected. All cases were divided randomly into research group (38 cases) and the control group (32 cases). The patients in research group were treated with mifepristone 50 mg once per 12 h, 3 times, on 3rd day, 600 μg misoprostol 2 h before abortion curettage; the patients in control group were treated with 600 μg misoprostol 2 h before abortion curettage. Results There was no significant difference between the 2 groups in complete abortion rate (P>0.05). Vaginal bleeding time in research group was significantly less than that in control group, there was significant difference between 2 groups, with χ²=4.12 and P<0.05. Blood volume in research group was significantly less than in control group, there was significant difference between the 2 groups, with χ²=5.30, and P<0.05.The incidence of side effects of research group was significantly less than that of control group, there was significant difference between 2 groups, with χ²=5.61 and P<0.05. Conclusion Mifepristone combined with misoprostol and misoprostol only for pregnancy termination had the same clinical effect. But mifepristone combined with misoprostol could effectively reduce the vaginal bleeding time and blood loss, and have fewer side effects.

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Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage

doi: 10.3969/j.issn.1006-0111.2014.01.018

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