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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(1): 65-67

XU Ziyi, SUN Yuhan, FAN Li, LU Guangzhao, ZHANG Yingnan, ZHANG He. Preparation and cytotoxicity of doxorubicin-containing gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(2): 73-77, 81. doi: 10.12206/j.issn.2097-2024.202308043
Citation: LI Jianying. Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 65-67. doi: 10.3969/j.issn.1006-0111.2014.01.018
shu

Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage

doi: 10.3969/j.issn.1006-0111.2014.01.018

  • Huzhou Family Planning Service Station of Zhejiang Province, Huzhou 313000, China

  • Received Date: 2013-05-22
  • Rev Recd Date: 2013-10-17
  • Objective To study the clinical effect of mifepristone combined with misoprostol and misoprostol in missed abortion curettage. Methods Seventy cases from April 2010 to August 2011 of medical termination of pregnancy in Huzhou family planning service station of Zhejiang Province were collected. All cases were divided randomly into research group (38 cases) and the control group (32 cases). The patients in research group were treated with mifepristone 50 mg once per 12 h, 3 times, on 3rd day, 600 μg misoprostol 2 h before abortion curettage; the patients in control group were treated with 600 μg misoprostol 2 h before abortion curettage. Results There was no significant difference between the 2 groups in complete abortion rate (P>0.05). Vaginal bleeding time in research group was significantly less than that in control group, there was significant difference between 2 groups, with χ2=4.12 and P<0.05. Blood volume in research group was significantly less than in control group, there was significant difference between the 2 groups, with χ2=5.30, and P<0.05.The incidence of side effects of research group was significantly less than that of control group, there was significant difference between 2 groups, with χ2=5.61 and P<0.05. Conclusion Mifepristone combined with misoprostol and misoprostol only for pregnancy termination had the same clinical effect. But mifepristone combined with misoprostol could effectively reduce the vaginal bleeding time and blood loss, and have fewer side effects.
  • [1] 季玉琴,张玉泉.胚胎停止发育病因与机制的研究进展[J].现代妇产科进展,2010,19(2):146-148.
    [2] 花 琪,程丽村,范晓芳,等.米非司酮配伍米索前列醇终止16~24周妊娠的随机对照研究[J].上海医学,2011,34(5):390-391.
    [3] 李树森.小剂量米非司酮联合米索前列醇终止妊娠的疗效观察[J].中国药房,2010,21(40):3798-3800.
    [4] 张晓霞,李 彬.米非司酮配伍米索前列醇终止13~25周妊娠70例效果观察[J].山东医药,2010,50(27):21.
    [5] 俞颂梅,耿菊惠,赵纯燕.不同剂量米非司酮配伍米索前列醇终止早孕的临床分析[J].江苏医药,2010,36(5):596-597.
    [6] 曾美苑,朱兰芳,李爱贤.米非司酮配伍米索前列醇终止12~16周妊娠80例临床分析[J].重庆医学,2009,38(9):1100-1101.
    [7] 盖牟慧子,闫 萍.米非司酮对子宫雌孕激素受体影响的研究进展[J].河北医科大学学报,2010,3(2):241-243.
    [8] 吕榜权.米索前列醇与米非司酮用于早孕人工流产软化宫颈的临床效果观察[J].广西医学,2011,33(7):869-870.
    [9] 张晓华,陶 芳.米索前列醇用于10~14周无痛人流的体会[J].中国实用医药,2011,6(18):145-146.
    [10] 韩 华,闫 萍.米非司酮终止早孕的研究进展[J].河北医科大学学报,2008,29(5):795-798.
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Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage

doi: 10.3969/j.issn.1006-0111.2014.01.018
  • Huzhou Family Planning Service Station of Zhejiang Province, Huzhou 313000, China
  • Received Date: 2013-05-22
  • Rev Recd Date: 2013-10-17

Abstract: Objective To study the clinical effect of mifepristone combined with misoprostol and misoprostol in missed abortion curettage. Methods Seventy cases from April 2010 to August 2011 of medical termination of pregnancy in Huzhou family planning service station of Zhejiang Province were collected. All cases were divided randomly into research group (38 cases) and the control group (32 cases). The patients in research group were treated with mifepristone 50 mg once per 12 h, 3 times, on 3rd day, 600 μg misoprostol 2 h before abortion curettage; the patients in control group were treated with 600 μg misoprostol 2 h before abortion curettage. Results There was no significant difference between the 2 groups in complete abortion rate (P>0.05). Vaginal bleeding time in research group was significantly less than that in control group, there was significant difference between 2 groups, with χ2=4.12 and P<0.05. Blood volume in research group was significantly less than in control group, there was significant difference between the 2 groups, with χ2=5.30, and P<0.05.The incidence of side effects of research group was significantly less than that of control group, there was significant difference between 2 groups, with χ2=5.61 and P<0.05. Conclusion Mifepristone combined with misoprostol and misoprostol only for pregnancy termination had the same clinical effect. But mifepristone combined with misoprostol could effectively reduce the vaginal bleeding time and blood loss, and have fewer side effects.

XU Ziyi, SUN Yuhan, FAN Li, LU Guangzhao, ZHANG Yingnan, ZHANG He. Preparation and cytotoxicity of doxorubicin-containing gold nanoparticles[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(2): 73-77, 81. doi: 10.12206/j.issn.2097-2024.202308043
Citation: LI Jianying. Effect comparison of mifepristone combined with misoprostol and misoprostol in missed abortion curettage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 65-67. doi: 10.3969/j.issn.1006-0111.2014.01.018
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