Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005
Citation: YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

Role of apoptosis in radiation-induced tissue damage

doi: 10.3969/j.issn.1006-0111.2014.02.005
  • Received Date: 2013-03-11
  • Rev Recd Date: 2013-06-14
  • Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.
  • [1] 周平坤,霍艳英,吴德昌. 辐射致癌效应与机制[J].辐射防护通讯,2007,27(1):7.
    [2] 童新,孙志贤. 辐射所致程序性细胞死亡的机制[J].国外医学·分子生物学分册,1995,l7(3):131.
    [3] Tomita M. Involvement of DNA-PK and ATM in radiation-and heat-induced DNA damage recognition and apoptotic cell death[J].J Radiat Res, 2010,51:493.
    [4] Slade D, Radman M. Oxidative stress resistance in Deinococcus radiodurans[J].Microbiol Mol Biol Rev,2011,75(1):133.
    [5] Nguyen TD, Maquart FX, Monboisse JC. Ionizing radiations and collagen metabolism:from oxygen free radicals to radio-induced late fibrosis[J].Radiat Phys Chem,2005, 72:381.
    [6] Orlowski R Z, Baldwin AS. NF-kappaB as a therapeutic target in cancer[J].Trends Mol Med,2002:385.
    [7] Reuter S, Gupta SC, Chaturvedi MM. Oxidative stress, inflammation, and cancer:how are they linked[J].Free Radical Biol Med, 2010, 49:1603.
    [8] Moeller BJ, Cao YT, Li CY. Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors:role of reoxygenation, free radicals, and stress granules[J].Cancer Cell, 2004, 5:429.
    [9] Mueller S, Bhargava S, Molinaro AM. Poly (ADP-Ribose) polymerase inhibitor MK-4827 together with radiation as a novel therapy for metastatic neuroblastoma[J].Anticancer Res, 2013, 33(3):755.
    [10] Liu XS. PARP inhibition as a prototype for synthetic lethal screens[J].Mol Biol, 2013, 986:123..
    [11] Shunkwiler L, Ferris G, Kunos C. Inhibition of poly(ADP-Ribose) polymerase enhances radiochemosensitivity in cancers proficient in DNA double-strand break repair[J].Int J Mol Sci, 2013, 14(2):3773.
    [12] Lowe SW. Renewing the debate over the p53 apoptotic response[J].Nature,1993:352.
    [13] Han JQ, Xu XJ, Qin HZ. The molecular mechanism and potential role of heat shock-induced P53 protein accumulation[J].Mol Cellul Biochem, 2013, 3:1.
    [14] Burger H, Nooter K, Boersma AW. Expression of p53, p21/waf/cip, bcl-2, bax, bcl-x, and bak in radiation-induced apoptosis in testicular germ cell tumor lines[J].Int J Radiat Oncol,1998, 41(2):415.
    [15] Wakatsuki M, Ohno T, Iwakawa M. P73 protein expression correlates with radiation-induced apoptosis in the lack of p53 response to radiation therapy for cervical cancer[J].Int J Radiat Oncol,2008, 70(4):1189.
    [16] Deng XZ, Yin XL, Allan R. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans[J].Science,2008, 322(5898):110.
    [17] Adriana HF, Chu CK, Ehleiter D. Ionizing radiation acts on cellular membranes to generate ceramide and initiate apoptosis[J].J Exp Med,1994, 180:525.
    [18] Rotolo J, Stancevic B, Zhang JJ, Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice[J].J Clin Invest,2012, Brief report:1.
    [19] Kolesnick R, Fuks Z. Radiation and ceramide-induced apoptosis[J].Oncogene,2003, 22:5897.
    [20] Niaudet C, Bonnaud S, Gouard S. Radiation induces p38-mediated endothelial cell death through ceramide generation and menbrane remodeling[J].Radioprotection, 2008, 43:140.
    [21] Chakravarti A, Noll E, Black PM. The anti-epidermal growth factor receptor monoclonal antibody, c225, enhances radiation-induced apoptosis in primary glioma cell lines through mediation of MAPK/JNK/p38 signaling pathways[J].Int J Radiat Oncol,2001, 51(3):102.
    [22] Blirando K, Hneino M, Martelly I. Mast cells and ionizing radiation induce a synergistic expression of inflammatory genes in endothelial cells by a mechanism involving p38α MAP kinase and (p65) NF-κB activation[J].Radiat Res,2012, 178(6):556.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Article Metrics

Article views(3150) PDF downloads(91) Cited by()

Related
Proportional views

Role of apoptosis in radiation-induced tissue damage

doi: 10.3969/j.issn.1006-0111.2014.02.005

Abstract: Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005
Citation: YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005
Reference (22)

Catalog

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return