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Volume 32 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(2): 121-123

ZHANG Liping. Determination of gardenoside and paeoniflorin in Ankun granule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 121-123. doi: 10.3969/j.issn.1006-0111.2014.02.012
Citation: ZHANG Liping. Determination of gardenoside and paeoniflorin in Ankun granule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 121-123. doi: 10.3969/j.issn.1006-0111.2014.02.012
shu

Determination of gardenoside and paeoniflorin in Ankun granule by HPLC

doi: 10.3969/j.issn.1006-0111.2014.02.012

  • Wenzhou Institute for Drug Control, Wenzhou 325028, China

  • Received Date: 2013-09-05
  • Rev Recd Date: 2013-11-07
  • Objective To establish the HPLC method for the determination of gardenoside and paeoniflorin in Ankun granule. Methods The column was Agilent Eclipse XDB C18 (250 mm×4.6 mm,5 μm),and the acetonitrile-water(14:86) was used as the mobile phase.The detective wavelength was set at 230 nm. Results For the gardenoside,the linear range was 0.0715 2-0.357 6 μg,r=0.999 8 and the average recovery was 98.22% with RSD of 1.25%.For the Paeoniflorin,the linear range was 0.071 97-0.359 85 μg,r=0.999 2 and the average recovery was 98.40% with RSD of 0.68%. Conclusion The method was simple,reliable,and accurate which could be applied to the quality control of the drug.
  • [1] 中华人民共和国卫生部药典委员会.卫生部药品标准中药成方制剂:第十九册[S].1998:72.
    [2] 吴 毅,张文惠,王永刚.HPLC法测定安坤颗粒中芍药苷的含量[J].江西中医学院学报,2002,14(1):42.
    [3] 汤 浩,封士兰,闵光涛,等. HPLC同时测定赤栀黄胶囊中栀子苷和芍药苷的含量[J].中成药,2004,26(5):361-364.
    [4] 李卫华.HPLC法测定丹栀逍遥丸中芍药苷的含量[J].海峡药学,2001,13(2):38.
    [5] 刘阿静,齐广才,刘珍叶,等. RP-HPLC法测定防风通圣丸中芍药苷、栀子苷、黄芩苷和连翘苷的含量[J].西北药学杂志,2012,27(5):415-417.
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Determination of gardenoside and paeoniflorin in Ankun granule by HPLC

doi: 10.3969/j.issn.1006-0111.2014.02.012
  • Wenzhou Institute for Drug Control, Wenzhou 325028, China
  • Received Date: 2013-09-05
  • Rev Recd Date: 2013-11-07

Abstract: Objective To establish the HPLC method for the determination of gardenoside and paeoniflorin in Ankun granule. Methods The column was Agilent Eclipse XDB C18 (250 mm×4.6 mm,5 μm),and the acetonitrile-water(14:86) was used as the mobile phase.The detective wavelength was set at 230 nm. Results For the gardenoside,the linear range was 0.0715 2-0.357 6 μg,r=0.999 8 and the average recovery was 98.22% with RSD of 1.25%.For the Paeoniflorin,the linear range was 0.071 97-0.359 85 μg,r=0.999 2 and the average recovery was 98.40% with RSD of 0.68%. Conclusion The method was simple,reliable,and accurate which could be applied to the quality control of the drug.

ZHANG Liping. Determination of gardenoside and paeoniflorin in Ankun granule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 121-123. doi: 10.3969/j.issn.1006-0111.2014.02.012
Citation: ZHANG Liping. Determination of gardenoside and paeoniflorin in Ankun granule by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 121-123. doi: 10.3969/j.issn.1006-0111.2014.02.012
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