The influence of rhGM-CSF gel to curing the CIN wound healing

ZHENG Jie; ZHU Zhenzhen; YU Rufen

doi:10.3969/j.issn.1006-0111.2014.02.013

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

Objective To study the influence of external recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) gel on wound healing after LEEP for curing the CIN. Methods 124 patients with CIN were selected and divided into two groups:the treatment group (73 cases) and the control group (51 cases). Both two groups were treated by LEEP, and the wound were covered by rhGM-CSF gel and sterile gauze, respectively. And then, the wound healing status of these two groups (the bleeding time and amount of vagina, preliminary healing time of wound callusing), curative effect and incidence of complications of these two groups were observed,and analyzed. Results The incidence of vaginal bleeding in both treatment group and control group whose bleeding time ≤ 2 weeks, >2weeks but ≤ 3weeks, >3weeks but ≤ 5 weeks, >5 weeks were 93.15% vs 23.52%, 5.48% vs 41.18%, 1.37% vs 17.39% and 0.00% vs 13.73%, respectively. The incidence of vaginal bleeding amount in both groups whose amount ≤ 20 ml, 21-49 ml and > 50 ml were 91.78% vs 27.45%, 8.22% vs 62.75% and 0.00% vs 9.80%, respectively. The average time for the wound healing of both groups were 8.1±2.4 days and 17.7±3.5 days, and these differences were all had statistical significance(P<0.05). The effective rates were 98.63% and 86.27%(P<0.05) when the patients were visited after 6 months. The incidence of complications were 1.37% and 13.73%(P<0.05), respectively. Conclusion rhGM-CSF could accelerate the wound healing of CIN patients after LEEP, and reduce the incidence of complications.

The influence of rhGM-CSF gel to curing the CIN wound healing

1. Ruian Hospital of traditional Chinese medicine, Ruian 325200, China

2. The Third Hospital Affiliated to Wenzhou Medical College, Ruian 325200, China

Received Date: 2013-07-30

Rev Recd Date: 2013-11-02

Key words:

Abstract: Objective To study the influence of external recombinant human granulocyte/macrophage colony-stimulating factor (rhGM-CSF) gel on wound healing after LEEP for curing the CIN. Methods 124 patients with CIN were selected and divided into two groups:the treatment group (73 cases) and the control group (51 cases). Both two groups were treated by LEEP, and the wound were covered by rhGM-CSF gel and sterile gauze, respectively. And then, the wound healing status of these two groups (the bleeding time and amount of vagina, preliminary healing time of wound callusing), curative effect and incidence of complications of these two groups were observed,and analyzed. Results The incidence of vaginal bleeding in both treatment group and control group whose bleeding time ≤ 2 weeks, >2weeks but ≤ 3weeks, >3weeks but ≤ 5 weeks, >5 weeks were 93.15% vs 23.52%, 5.48% vs 41.18%, 1.37% vs 17.39% and 0.00% vs 13.73%, respectively. The incidence of vaginal bleeding amount in both groups whose amount ≤ 20 ml, 21-49 ml and > 50 ml were 91.78% vs 27.45%, 8.22% vs 62.75% and 0.00% vs 9.80%, respectively. The average time for the wound healing of both groups were 8.1±2.4 days and 17.7±3.5 days, and these differences were all had statistical significance(P<0.05). The effective rates were 98.63% and 86.27%(P<0.05) when the patients were visited after 6 months. The incidence of complications were 1.37% and 13.73%(P<0.05), respectively. Conclusion rhGM-CSF could accelerate the wound healing of CIN patients after LEEP, and reduce the incidence of complications.

HTML

Reference (15)

[1]	Johnson N,Khalili M,Hirschwitz L,et al.Predicting residual disease after rexcision of cervical dysplasia[J].Int J Obstetr Gynec,2003,110(10):952-955.
[2]	乐杰.妇产科学[M].7版.北京:人民卫生出版社,2008:262-263.
[3]	陈炯,韩春茂,陈国贤,等.重组人粒细胞-巨噬细胞集落刺激因子凝胶剂促进深Ⅱ度烧伤愈合[J].中华创伤杂志,2008,24,(3):224-227.
[4]	王志勇,张勤,廖镇江,等.重组人粒细胞-巨噬细胞集落刺激因子对深Ⅱ度烧伤创面的治疗作用[J].中华烧伤杂志,2008,24(2):107:107-110.
[5]	Mann A,Breuhahn K,Schirmacher P,et al.Keratinocyte-derived granulocyte-macropage colony stimulating factor accelrates wound healing:stimulation and vascularization[J].J Invest Dermatol,2001,117(6):1382-1390.
[6]	Jaschke E,Zabernigg A,Gattringer C.Recmbinant human graulocyte-macrophage colony-stimulating faactor applied locally in low doses enhances healing and prevents recurrence of chronic venous ulcers[J].Int J Dermatol,1999,38(5):380-386.
[7]	欧邦军,梁自乾.胰岛素联合表皮生长因子治疗糖尿病性烧伤创面的研究进展[J].实用医学杂志,2010,26(8):1448-1450.
[8]	郭敏,崔文慧,徐祥,等.小鼠急性皮肤缺损创面粒-巨噬细胞集落刺激因子表达特点及其作用机制[J].中华创伤杂志,2011,27(7):648-653.
[9]	Groves RW,Schmidt-Lucke JA.Recombinant human GM-CSF in the treatment of poorly healing wounds[J].Adv Skin Wound Care,2000,13(3):107-112.
[10]	Fang Y,Cong SJ,Xu YH,et al.Impaired cutaneous wound healing in granulocyte/macrophage colony-stimulating factor knockout mice[J].Br J Dermatol,2007,157(3):458-465.
[11]	程志华,程小平,彭文,等.富林蜜与外用重组人粒细胞-巨噬细胞刺激因子凝胶联合应用治疗深Ⅱ度烧伤临床观察[J].中华损伤与修复杂志,2011,6(2):259-263.
[12]	赵洪猛,张斌,冯锐,等.巨噬细胞及粒细胞巨噬细胞集落刺激因子促进大鼠腹壁动脉穿支皮瓣存活的作用及其机制[J].中华实验外科杂志,2011,28(5):687.
[13]	兰海霞,博晓真,新燕,等.粒细胞-巨噬细胞集落刺激因子的研究进展[J].临床儿科杂志,2005,2(12):64-66.
[14]	邱学文,王甲汉,杨磊,等.重组人粒细胞-巨噬细胞集落刺激因子治疗烧伤后残余创面[J].实用医学杂志,2011,27(7):1195-1196.
[15]	Mann A,Niekisch K,Schirmacher P,et al.Granulocyte-macrophage colony-stimulating factor is essential for normal wound healing[J].J Invest Dermatol Symp Proc,2006,11(1):82-92.

Message Board

The influence of rhGM-CSF gel to curing the CIN wound healing

doi: 10.3969/j.issn.1006-0111.2014.02.013

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views