The effect of sufentanil on the minimum local analgesic concentration of epidural lidocaine

XIE Fanghua; SONG Shaobo; ZHANG Jian

doi:10.3969/j.issn.1006-0111.2014.02.016

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Objective To compare the effect of different dosage of sulfentanil on the minimum local analgesic concentration of epidural licocaine. Methods 90 patients with urology and anorectic surgery, ASA Ⅰ or Ⅱ, 32-63 years, were randomly divided into 3 groups (n=30):L group (only lidocaine), LSF₁ group (lidocaine +10 μg sufentanil) and LSF₂ group (lidocaine +20 μg sufentanil). First case of patient in each group was given 20 ml of 1% lidocaine, thereafter in accordance with VAS score of the patient, the lidocaine was given by in turn decrease method according to the sequential changes in the concentration of lidocaine. The concentration gradient was 0.1%, and block pain degree was observed after 30 minutes (VAS ≤ 1 is valid), lower limb motor block Bromage classification was observed. MLAC and 95% confidence intervals(CI) of lidocaine in 3 groups was calculated according to Dixon and Massey. Results MLAC of lidocaine on adult lumbar epidural in LSF₁ group was 0.590% (95%CI 0.537%-0.660%), MLAC in LSF₂ group was 0.382% (95%CI 0.329%-0.446%), and MLAC of both groups were significantly lower than L group 0.781% (95%CI 0.728%-0.844%) (P<0.01). In effective analgesia cases, Bromage grade of LSF₂ group was significantly lower than that of L and LSF₁ group. Conclusion Epidural lidocaine combined with 10 and 20 μg sufentanil could significantly reduce local anesthetic effect of the minimum analgesic concentration of lidocaine, and no significant adverse reactions. Epidural lidocaine combined with 20 μg sufentanil reached the same analgesic effect, and significantly reduce the lower extremity motor nerve block. So 20 μg sufentanil might be the best combined dose.

The effect of sufentanil on the minimum local analgesic concentration of epidural lidocaine

1. Department of Anesthesiology, Xiaoshan Hospital of Zhejiang Province, Xiaoshan 311202, China

2. Department of Anesthesiology, First Affiliated Hospital of Zhejiang University, Hangzhou 310003, China

Received Date: 2013-05-31

Rev Recd Date: 2013-12-11

Key words:

sufentanil /
lidocaine /
epidural anesthesia /
the minimum local analgesic concentration

Abstract: Objective To compare the effect of different dosage of sulfentanil on the minimum local analgesic concentration of epidural licocaine. Methods 90 patients with urology and anorectic surgery, ASA Ⅰ or Ⅱ, 32-63 years, were randomly divided into 3 groups (n=30):L group (only lidocaine), LSF₁ group (lidocaine +10 μg sufentanil) and LSF₂ group (lidocaine +20 μg sufentanil). First case of patient in each group was given 20 ml of 1% lidocaine, thereafter in accordance with VAS score of the patient, the lidocaine was given by in turn decrease method according to the sequential changes in the concentration of lidocaine. The concentration gradient was 0.1%, and block pain degree was observed after 30 minutes (VAS ≤ 1 is valid), lower limb motor block Bromage classification was observed. MLAC and 95% confidence intervals(CI) of lidocaine in 3 groups was calculated according to Dixon and Massey. Results MLAC of lidocaine on adult lumbar epidural in LSF₁ group was 0.590% (95%CI 0.537%-0.660%), MLAC in LSF₂ group was 0.382% (95%CI 0.329%-0.446%), and MLAC of both groups were significantly lower than L group 0.781% (95%CI 0.728%-0.844%) (P<0.01). In effective analgesia cases, Bromage grade of LSF₂ group was significantly lower than that of L and LSF₁ group. Conclusion Epidural lidocaine combined with 10 and 20 μg sufentanil could significantly reduce local anesthetic effect of the minimum analgesic concentration of lidocaine, and no significant adverse reactions. Epidural lidocaine combined with 20 μg sufentanil reached the same analgesic effect, and significantly reduce the lower extremity motor nerve block. So 20 μg sufentanil might be the best combined dose.

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Reference (11)

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The effect of sufentanil on the minimum local analgesic concentration of epidural lidocaine

doi: 10.3969/j.issn.1006-0111.2014.02.016

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