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Volume 32 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2014  >  32(6): 448-452

LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
Citation: LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
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Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS

doi: 10.3969/j.issn.1006-0111.2014.06.012
  • 1.

    Pharmaceutical Analysis Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital affiliated to Second Military Medical University, Shanghai 200438, China

  • Received Date: 2013-06-09
  • Rev Recd Date: 2013-11-13
  • Objective To identify the chemical components in Artemisiae argyi folium by rapid resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOFMS). Methods The separation was performed on an Agilent Eclipse C18 column (2.1 mmü100 mm,1.8 μm ). The mobile phase consisted of acetonitrile (A) and 0.1% formic acid (B) were in gradient elution.The flowing rate was 0.35 ml/min, the injection volume was 1 μl and the temperature of column was 40℃. Time of flight mass spectrometer (TOFMS) with electro spray ion source (ESI) was applied to qualitative analysis under the positive ion mode,and mass scan range was m/z 100-1 500. Results 31 chemical compounds in Artemisiae argyi folium were identified unequivocally. Conclusion A rapid and efficient RRLC-TOFMS approach for identifying the chemical constituents of Artemisiae argyi folium had been successfully established,which paved a way for quality control and further in vivo studies of Artemisiae argyi folium.
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    [7] 吕 磊,张 海,赵 亮,等.RRLC-TOF/MS快速鉴别中药淫羊藿中43种化学成分[J].第二军医大学学报,2011,32(3):941-946.
    [8] 赵 亮,田文君,吕 磊.HPLC-TOF/MS对中药扶正平消胶囊化学成分的鉴别[J].第二军医大学学报,2012,33(7):770-779.
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    [10] Tian F,Liu L,Dou DQ,et al.Chemical comparison of Artemisia borealis and three Chinese Artemisia plant[J].J Chin Pharm Sci,2007(16):27-32.
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    [12] Lopes-Lutz D,Alviano DS,Alviano CS,et al.Screening of chemical composition, antimicrobial and antioxidant activities of Artemisia essential oils[J].Phytochemistry,2008(69):1732-1738.
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Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS

doi: 10.3969/j.issn.1006-0111.2014.06.012
  • 1. Pharmaceutical Analysis Center, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital affiliated to Second Military Medical University, Shanghai 200438, China
  • Received Date: 2013-06-09
  • Rev Recd Date: 2013-11-13

Abstract: Objective To identify the chemical components in Artemisiae argyi folium by rapid resolution liquid chromatography-time of flight mass spectrometry (RRLC-TOFMS). Methods The separation was performed on an Agilent Eclipse C18 column (2.1 mmü100 mm,1.8 μm ). The mobile phase consisted of acetonitrile (A) and 0.1% formic acid (B) were in gradient elution.The flowing rate was 0.35 ml/min, the injection volume was 1 μl and the temperature of column was 40℃. Time of flight mass spectrometer (TOFMS) with electro spray ion source (ESI) was applied to qualitative analysis under the positive ion mode,and mass scan range was m/z 100-1 500. Results 31 chemical compounds in Artemisiae argyi folium were identified unequivocally. Conclusion A rapid and efficient RRLC-TOFMS approach for identifying the chemical constituents of Artemisiae argyi folium had been successfully established,which paved a way for quality control and further in vivo studies of Artemisiae argyi folium.

LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
Citation: LI Ling, Lü Lei, DONG Xin, LV Diya, LOU Ziyang. Rapid identification of chemical components in Artemisiae argyi folium by RRLC-TOFMS[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 448-452. doi: 10.3969/j.issn.1006-0111.2014.06.012
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