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ZENG Qian, JI Hui, TANG Huihui, XIE Xueyuan. Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 456-459. doi: 10.3969/j.issn.1006-0111.2014.06.014
Citation: ZENG Qian, JI Hui, TANG Huihui, XIE Xueyuan. Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 456-459. doi: 10.3969/j.issn.1006-0111.2014.06.014

Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound

doi: 10.3969/j.issn.1006-0111.2014.06.014
  • Received Date: 2014-04-08
  • Rev Recd Date: 2014-09-09
  • Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin. Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins inclusion compound. The PXRD, DSC and IR techniques had been used to characterize the inclusion compound. Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound, and the formation of the inclusion compound could increase solubility by 120.7 times. Conclusion The inclusion compound preparation method was simple and available, which was suitable to improve the bioavailability.
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    [11] 毛利娟,王永禄,李学明,等. 共研磨法提高兰索拉唑的溶出度[J].中国医药工业杂志,2011,42(8):595-599.
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Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound

doi: 10.3969/j.issn.1006-0111.2014.06.014

Abstract: Objective To prepare the water soluble chrysin-hydroxypropyl-β-cyclodextrins inclusion compound and widen the administration path of chrysin. Methods The cogrinding method had been used to prepare chrysin-hydroxypropyl-β-cyclodextrins inclusion compound. The PXRD, DSC and IR techniques had been used to characterize the inclusion compound. Results Chrysin and hydroxypropyl-β-cyclodextrins had formed the inclusion compound, and the formation of the inclusion compound could increase solubility by 120.7 times. Conclusion The inclusion compound preparation method was simple and available, which was suitable to improve the bioavailability.

ZENG Qian, JI Hui, TANG Huihui, XIE Xueyuan. Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 456-459. doi: 10.3969/j.issn.1006-0111.2014.06.014
Citation: ZENG Qian, JI Hui, TANG Huihui, XIE Xueyuan. Preparation and characterization of chrysin-hydroxypropyl-β-cyclodextrins inclusion compound[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 456-459. doi: 10.3969/j.issn.1006-0111.2014.06.014
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