Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

GAO Hongyuan; WU Jianyong; NI Shumin

doi:10.3969/j.issn.1006-0111.2015.01.003

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Volume 33 Issue 1

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2015 > 33(1): 9-12,16

GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003

Citation:

GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003

Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

doi: 10.3969/j.issn.1006-0111.2015.01.003

1.
Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Oncology, Shanghai 200041, China
2.
Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Clinical Pharmacology, Shanghai 200041, China
3.
Department of Oncology, Affiliated Hospital of Ningbo University, Ningbo 315020, China

Received Date: 2013-11-12
Rev Recd Date: 2014-04-21

Abstract

The delivery of therapeutical agents for brain tumors' treatment is enormously prevented by the presence of blood-brain barrier.Nano-carriers such as nano-particles,liposomes and micelles can significantly increase the transport of drugs across the blood-brain barrier.The dual-targeting nano-carriers modified by one or two functional groups can further increase the brain delivery of drugs as well as their accumulation in brain tumors,resulting in significant improvement in the diagnosis and therapy of brain tumors.This article mainly focused on the recent development of strategies and functional groups of dual-targeting nano-carriers,providing a reference for relevant investigations.
- dual-targeting,
- nano-carrier,
- brain tumor,
- diagnosis,
- therapy

References

[1]	Pardridge WM.BBB-Genomics:creating new openings for brain-drug targeting[J].Drug Discov Today,2001,6(8):381-383.
[2]	van Rooy I,Mastrobattista E,Storm G,et al.Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain[J].J Control Release,2011,150(1):30-36.
[3]	Chen H,Qin Y,Zhang Q,et al.Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas[J]. Eur J Pharm Sci,2011,44(1-2):164-173.
[4]	Demeule M,Currie JC,Bertrand Y,et al.Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2[J].J Neurochem,2008,106(4):1534-1544.
[5]	Xin H,Jiang X,Gu J,et al.Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma[J].Biomaterials,2011,32(18):4293-4305.
[6]	Xin H,Sha X,Jiang X,et al.Anti-glioblastoma efficacy and safety of paclitaxel-loading angiopep-conjugated dual targeting PEG-PCL nanoparticles[J].Biomaterials,2012,33(32):8167-8176.
[7]	Xin H,Sha X,Jiang X,et al.The brain targeting mechanism of angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles[J].Biomaterials,2012,33(5):1673-1681.
[8]	Huang S,Li J,Han L,et al.Dual targeting effect of angiopep-2-modified,DNA-loaded nanoparticles for glioma[J].Biomaterials,2011,32(28):6832-6838.
[9]	Ren J,Shen S,Wang D,et al.The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2[J].Biomaterials,2012,33(11):3324-3333.
[10]	Li J,Zhou L,Ye D,et al.Choline-derivate-modified nanoparticles for brain-targeting gene delivery[J].Adv Mater,2011,23(39):4516-4520.
[11]	Machová E,O'Regan S,Newcombe J,et al.Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS,and its role in choline uptake[J].J Neurochem,2009,110(4):1297-1309.
[12]	Li J,Guo Y,Kuang Y,et al.Choline transporter-targeting and co-delivery system for glioma therapy[J].Biomaterials,2013,34(36):9142-9148.
[13]	Li J,Huang S,Shao K,et al.A choline derivate-modified nanoprobe for glioma diagnosis using MRI[J].Sci Rep,2013,3:1623.
[14]	Malcor JD,Payrot N,David M,et al.Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting[J].J Med Chem,2012,55(5):2227-2241.
[15]	Zhang B,Sun X,Mei H,et al.LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma[J].Biomaterials,2013,34(36):9171-9182.
[16]	Zhu L,Wang H,Wang L,et al.High-affinity peptide against MT1-MMP for in vivo tumor imaging[J].J Control Release,2011, 150(3):248-255.
[17]	Gu G,Gao X,Hu Q,et al.The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells[J].Biomaterials,2013,34(21):5138-5148.
[18]	Li J,Feng L,Fan L,et al.Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides[J].Biomaterials,2011,32(21):4943-4950.
[19]	Guo J,Gao X,Su L,et al.Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery[J].Biomaterials,2011,32(31):8010-8020.
[20]	Gao H,Qian J,Cao S,et al.Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles[J].Biomaterials,2012,33(20):5115-5123.
[21]	Gao JQ,Lv Q,Li LM,et al.Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes[J].Biomaterials,2013,34(22):5628-5639.
[22]	Paleĉek J,Dräger G,Kirschning A.A practical large-scale synthesis of cyclic RGD pentapeptides suitable for further functionalization through‘click’chemistry[J].Synthesis,2011,(4):653-661.
[23]	Zhang P,Hu L,Yin Q,et al.Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy[J].Mol Pharm,2012,9(6):1590-1598.
[24]	Sugimoto Y,Tsukahara S,Imai Y,et al.Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists[J].Mol Cancer Ther,2003,2(1):105-112.
[25]	Tian W,Ying X,Du J,et al.Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats[J].Eur J Pharm Sci,2010,41(2):232-243.
[26]	He H,Li Y,Jia XR,et al.PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors[J].Biomaterials,2011,32(2):478-487.
[27]	Du J,Lu WL,Ying X,et al.Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals[J].Mol Pharm,2009,6(3):905-917.

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通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

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Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

1. Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Oncology, Shanghai 200041, China

2. Huashan Hospital Affiliated to Fudan University Jing'an Branch, Department of Clinical Pharmacology, Shanghai 200041, China

3. Department of Oncology, Affiliated Hospital of Ningbo University, Ningbo 315020, China

Received Date: 2013-11-12

Rev Recd Date: 2014-04-21

Key words:

Abstract: The delivery of therapeutical agents for brain tumors' treatment is enormously prevented by the presence of blood-brain barrier.Nano-carriers such as nano-particles,liposomes and micelles can significantly increase the transport of drugs across the blood-brain barrier.The dual-targeting nano-carriers modified by one or two functional groups can further increase the brain delivery of drugs as well as their accumulation in brain tumors,resulting in significant improvement in the diagnosis and therapy of brain tumors.This article mainly focused on the recent development of strategies and functional groups of dual-targeting nano-carriers,providing a reference for relevant investigations.

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Reference (27)

[1]	Pardridge WM.BBB-Genomics:creating new openings for brain-drug targeting[J].Drug Discov Today,2001,6(8):381-383.
[2]	van Rooy I,Mastrobattista E,Storm G,et al.Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain[J].J Control Release,2011,150(1):30-36.
[3]	Chen H,Qin Y,Zhang Q,et al.Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas[J]. Eur J Pharm Sci,2011,44(1-2):164-173.
[4]	Demeule M,Currie JC,Bertrand Y,et al.Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2[J].J Neurochem,2008,106(4):1534-1544.
[5]	Xin H,Jiang X,Gu J,et al.Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma[J].Biomaterials,2011,32(18):4293-4305.
[6]	Xin H,Sha X,Jiang X,et al.Anti-glioblastoma efficacy and safety of paclitaxel-loading angiopep-conjugated dual targeting PEG-PCL nanoparticles[J].Biomaterials,2012,33(32):8167-8176.
[7]	Xin H,Sha X,Jiang X,et al.The brain targeting mechanism of angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles[J].Biomaterials,2012,33(5):1673-1681.
[8]	Huang S,Li J,Han L,et al.Dual targeting effect of angiopep-2-modified,DNA-loaded nanoparticles for glioma[J].Biomaterials,2011,32(28):6832-6838.
[9]	Ren J,Shen S,Wang D,et al.The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2[J].Biomaterials,2012,33(11):3324-3333.
[10]	Li J,Zhou L,Ye D,et al.Choline-derivate-modified nanoparticles for brain-targeting gene delivery[J].Adv Mater,2011,23(39):4516-4520.
[11]	Machová E,O'Regan S,Newcombe J,et al.Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS,and its role in choline uptake[J].J Neurochem,2009,110(4):1297-1309.
[12]	Li J,Guo Y,Kuang Y,et al.Choline transporter-targeting and co-delivery system for glioma therapy[J].Biomaterials,2013,34(36):9142-9148.
[13]	Li J,Huang S,Shao K,et al.A choline derivate-modified nanoprobe for glioma diagnosis using MRI[J].Sci Rep,2013,3:1623.
[14]	Malcor JD,Payrot N,David M,et al.Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting[J].J Med Chem,2012,55(5):2227-2241.
[15]	Zhang B,Sun X,Mei H,et al.LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma[J].Biomaterials,2013,34(36):9171-9182.
[16]	Zhu L,Wang H,Wang L,et al.High-affinity peptide against MT1-MMP for in vivo tumor imaging[J].J Control Release,2011, 150(3):248-255.
[17]	Gu G,Gao X,Hu Q,et al.The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells[J].Biomaterials,2013,34(21):5138-5148.
[18]	Li J,Feng L,Fan L,et al.Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides[J].Biomaterials,2011,32(21):4943-4950.
[19]	Guo J,Gao X,Su L,et al.Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery[J].Biomaterials,2011,32(31):8010-8020.
[20]	Gao H,Qian J,Cao S,et al.Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles[J].Biomaterials,2012,33(20):5115-5123.
[21]	Gao JQ,Lv Q,Li LM,et al.Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes[J].Biomaterials,2013,34(22):5628-5639.
[22]	Paleĉek J,Dräger G,Kirschning A.A practical large-scale synthesis of cyclic RGD pentapeptides suitable for further functionalization through‘click’chemistry[J].Synthesis,2011,(4):653-661.
[23]	Zhang P,Hu L,Yin Q,et al.Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy[J].Mol Pharm,2012,9(6):1590-1598.
[24]	Sugimoto Y,Tsukahara S,Imai Y,et al.Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists[J].Mol Cancer Ther,2003,2(1):105-112.
[25]	Tian W,Ying X,Du J,et al.Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats[J].Eur J Pharm Sci,2010,41(2):232-243.
[26]	He H,Li Y,Jia XR,et al.PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors[J].Biomaterials,2011,32(2):478-487.
[27]	Du J,Lu WL,Ying X,et al.Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals[J].Mol Pharm,2009,6(3):905-917.

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Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

doi: 10.3969/j.issn.1006-0111.2015.01.003

Abstract

References

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通讯作者: 陈斌, bchen63@163.com

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