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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(1): 36-39,43

GONG Zhirong, HE Wenting, SUN Zhiguo, GUO Haixia, ZHONG Yanqiang, LU Ying. Preparation and characterization of salinomycin sodium loaded nano liposomes[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 36-39,43. doi: 10.3969/j.issn.1006-0111.2015.01.009
Citation: GONG Zhirong, HE Wenting, SUN Zhiguo, GUO Haixia, ZHONG Yanqiang, LU Ying. Preparation and characterization of salinomycin sodium loaded nano liposomes[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 36-39,43. doi: 10.3969/j.issn.1006-0111.2015.01.009
shu

Preparation and characterization of salinomycin sodium loaded nano liposomes

doi: 10.3969/j.issn.1006-0111.2015.01.009
  • 1.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    No.266 Hospital of PLA, Chengde 067000, China

  • Received Date: 2014-09-27
  • Rev Recd Date: 2014-11-16
  • Objective To prepare and characterize salinomycin sodium-loaded nano liposomes(SLN). Methods The nano liposomes were prepared by a thin-film dispersion method.The formula of SLN was optimized by regulating the cholesterol ratio of the nano liposomes,using the encapsulation efficacy (EE) of SLN as the primary outcome measure. Results Transmission electron microscope (TEM) showed that SLN was round and had a good dispersion.Dynamic laser scatter (DLS) showed that SLN was of a desired size of 99 nm,and zeta potential of -33.5 mV.EE of SLN was 85.7% and drug loading of 6.7%.According to the formulation of nano liposomes,the concentration of salinomycin sodium in water was greatly improved by 15 folds.Additionally,the nano liposomes were observed to exhibit sustained release characteristics. Conclusion Salinomycin sodium-loaded nanoliposomes of a desired size of about 100 nm were obtained,which were well dispersion,and high EE and drug loading.Solid pharmaceutics foundation for the activity examination of SLN was provided in this research.
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Preparation and characterization of salinomycin sodium loaded nano liposomes

doi: 10.3969/j.issn.1006-0111.2015.01.009
  • 1. School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 2. No.266 Hospital of PLA, Chengde 067000, China
  • Received Date: 2014-09-27
  • Rev Recd Date: 2014-11-16

Abstract: Objective To prepare and characterize salinomycin sodium-loaded nano liposomes(SLN). Methods The nano liposomes were prepared by a thin-film dispersion method.The formula of SLN was optimized by regulating the cholesterol ratio of the nano liposomes,using the encapsulation efficacy (EE) of SLN as the primary outcome measure. Results Transmission electron microscope (TEM) showed that SLN was round and had a good dispersion.Dynamic laser scatter (DLS) showed that SLN was of a desired size of 99 nm,and zeta potential of -33.5 mV.EE of SLN was 85.7% and drug loading of 6.7%.According to the formulation of nano liposomes,the concentration of salinomycin sodium in water was greatly improved by 15 folds.Additionally,the nano liposomes were observed to exhibit sustained release characteristics. Conclusion Salinomycin sodium-loaded nanoliposomes of a desired size of about 100 nm were obtained,which were well dispersion,and high EE and drug loading.Solid pharmaceutics foundation for the activity examination of SLN was provided in this research.

GONG Zhirong, HE Wenting, SUN Zhiguo, GUO Haixia, ZHONG Yanqiang, LU Ying. Preparation and characterization of salinomycin sodium loaded nano liposomes[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 36-39,43. doi: 10.3969/j.issn.1006-0111.2015.01.009
Citation: GONG Zhirong, HE Wenting, SUN Zhiguo, GUO Haixia, ZHONG Yanqiang, LU Ying. Preparation and characterization of salinomycin sodium loaded nano liposomes[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 36-39,43. doi: 10.3969/j.issn.1006-0111.2015.01.009
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