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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(3): 250-252

ZHANG Jianhua, XU Yueming, HE Yuqiong, SONG Hongtao, DU Juan, ZHANG Qiaoyan. Studies on content determination and extraction method of iridoid glycosides in Morinda of ficinalis How[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 328-333. doi: 10.3969/j.issn.1006-0111.2017.04.010
Citation: WU Lihong, CHU Zhongying, LIU Huijun. Simultaneous determination of four ingredients in Gan Bawei capsule by HPLC-DAD[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 250-252. doi: 10.3969/j.issn.1006-0111.2015.03.015
shu

Simultaneous determination of four ingredients in Gan Bawei capsule by HPLC-DAD

doi: 10.3969/j.issn.1006-0111.2015.03.015

  • Shanghai Songjiang Institute for Food and Drug Control, Shanghai 201600, China

  • Received Date: 2014-02-18
  • Rev Recd Date: 2014-12-12
  • Objective To establish an HPLC-DAD method for simultaneous determination of four ingredients in Gan Bawei capsule. Methods HPLC method was adopted with C18 column(250 mm ×4.6 mm, 5 μm), Acetonitrile as mobile phase A and water as mobile phase B in gradient elution mode. The detection wavelength was 240 nm and the flow rate was 1.0 ml/min. Results Salvianolic acid B reference substance was excellently linear in the range of 15.026~100.17 μg/ml, the average recovery was 96.6%(n=6)and RSD was 1.8%(n=6). Paeoniflorin reference substance was excellently linear in the range of 14.335~95.564 μg/ml, the average recovery was 97.0%(n=6)and RSD was 1.7%(n=6).Polydatin reference substance was excellently linear in the range of 8.235-54.90 μg/ml, the average recovery was 97.2%(n=6)and RSD was 1.8%(n=6).Emodin reference substance was excellently linear in the range of 1.582 5-10.55 μg/ml, the average recovery was 98.1%(n=6)and RSD was 1.7%(n=6). Conclusion The method was easy, accurate, reproducible, specific and without interference in negative control, which could be used for quality control of Gan Bawei capsule.
  • [1] 上海市食品药品监督管理局.SYZ-ZF-014-2004 上海市医疗机构制剂标准汇编[S].2014-6-16.
    [2] 国家药典委员会.中华人民共和国药典2010年版一部[S].北京:中国医药科技出版社,2010:22,70,96,194,569,592,958,1141.
    [3] 国家药典委员会.国家药品标准(新药转正标准)中药第七十册[S]. 北京: 2008:4.
    [4] 国家药典委员会.国家药品标准(新药转正标准)中药第七十一册[S].北京: 2008:32.
    [5] 国家药典委员会.国家药品标准(新药转正标准)中药第七十六册[S].北京: 2009:64.
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Simultaneous determination of four ingredients in Gan Bawei capsule by HPLC-DAD

doi: 10.3969/j.issn.1006-0111.2015.03.015
  • Shanghai Songjiang Institute for Food and Drug Control, Shanghai 201600, China
  • Received Date: 2014-02-18
  • Rev Recd Date: 2014-12-12

Abstract: Objective To establish an HPLC-DAD method for simultaneous determination of four ingredients in Gan Bawei capsule. Methods HPLC method was adopted with C18 column(250 mm ×4.6 mm, 5 μm), Acetonitrile as mobile phase A and water as mobile phase B in gradient elution mode. The detection wavelength was 240 nm and the flow rate was 1.0 ml/min. Results Salvianolic acid B reference substance was excellently linear in the range of 15.026~100.17 μg/ml, the average recovery was 96.6%(n=6)and RSD was 1.8%(n=6). Paeoniflorin reference substance was excellently linear in the range of 14.335~95.564 μg/ml, the average recovery was 97.0%(n=6)and RSD was 1.7%(n=6).Polydatin reference substance was excellently linear in the range of 8.235-54.90 μg/ml, the average recovery was 97.2%(n=6)and RSD was 1.8%(n=6).Emodin reference substance was excellently linear in the range of 1.582 5-10.55 μg/ml, the average recovery was 98.1%(n=6)and RSD was 1.7%(n=6). Conclusion The method was easy, accurate, reproducible, specific and without interference in negative control, which could be used for quality control of Gan Bawei capsule.

ZHANG Jianhua, XU Yueming, HE Yuqiong, SONG Hongtao, DU Juan, ZHANG Qiaoyan. Studies on content determination and extraction method of iridoid glycosides in Morinda of ficinalis How[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 328-333. doi: 10.3969/j.issn.1006-0111.2017.04.010
Citation: WU Lihong, CHU Zhongying, LIU Huijun. Simultaneous determination of four ingredients in Gan Bawei capsule by HPLC-DAD[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(3): 250-252. doi: 10.3969/j.issn.1006-0111.2015.03.015
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