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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(4): 363-365

YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
Citation: YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
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Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome

doi: 10.3969/j.issn.1006-0111.2015.04.019

  • Department of Bio-therapy, Eastern Hepatobiliary Surgical Hospital affliated to Second Military Medical University, Shanghai 200438, China

  • Received Date: 2015-02-11
  • Rev Recd Date: 2015-05-14
  • Objective To investigate the clinical features and treatment of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) associated hemophagocytic syndrome (HPS). Methods A retrospective analysis of case clinical data with liver cirrhosis complicated by SPTCL associated HPS was done in August 2014 in our hospital. Results Because of different phenotypes of T cell receptor (TCR), the aggression, treatment response and prognosis of the disease were significantly different. The patients with HPS had poor treatment effect and short survival period. Conclusion Liver cirrhosis with hepatitis B complicated by SPTCL associated HPS is rare, Bone marrow morphology, pathology, immunohistochemistry and gene rearrangement detection as soon as possible are important for early diagnosis.To control HBV early and effectively is particularly important. Early diagnosis and treatment are important to prolong survival.
  • [1] Gonzalez CL, Medeiros LJ, Braziel RM, et al.T-cell lymphoma involving subcutaneous tissue A clinicopathologic entity commonly associated with hemophagocytic syndrome[J]. Am J Surg Pathol,l991,15:17-27.
    [2] Go RS, Wester SM.Immunophenotypic and molecular features, clinical outcomes, treatments and prognostic factors associated with subcutaneous panniculitis-like T-cell lymphoma: a systematic analysis of 156 patients reported in the literature[J].Cancer, 2004,l01(6):1404-1413.
    [3] Takeshita M,Okamura S,Oshiro Y, et al.Clinicopathologic differences between 22 cases of CD56-negative and CD56-positive subcutaneous panniculitis-like lymphoma in Japan[J].Hum Pathol,2004,35(2):231-239.
    [4] 马 兰,柴俊月,郑雯琦,等继发于淋巴瘤的嗜血细胞综合征6例临床分析[J].世界最新医学信息文摘,2014,14(2):96.
    [5] Huang JJ, Cai MY, Ye S,et al. Clinical analysis of 19 cases of subcutaneous panniculitis T-cell lymphoma with literature review[J]. Ai Zheng,2009,28 (10): 1093-1099.
    [6] Briki H,Bouaziz J D,Molinier-Frenkel V, et al.Subcutaneous panniculitis-like T-cell lymphoma αβ:complete sustained remission with corticosteroids and methotrexate[J].Br J Dermatol, 2010,163(5):1136-1138.
    [7] Guenova E, Schanz S, Hoetzenecker W, et al. Systemic corticosteroids for subcutaneous panniculitis-like T-cell lymphoma[J]. Br J Dermatol,2014,171 (4): 891-894.
    [8] Sakurai E, Satoh T, Akiko YA, et al. Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with hemophagocytosis (HPS): successful treatment using high-dose chemotherapy (BFM-NHL & ALL-90) and autologous peripheral blood stem cell transplantation[J]. J Clin Exp Hematop, 2013,53 (2): 135-140.
    [9] Chen R, Liu L,Liang YM,et al. Treatment relapsed subcutaneous panniculitis-like T-cell lymphoma together HPS by cyclosporin A[J]. Hematol Rep,2010,2 (1): e9.
    [10] Zhang X,Schlaak M,Fabri M, et al.Successful treatment of a panniculitis-like primary cutaneous T-Cell lymphoma of the α/β type with bexarotene[J].Case Rep Dennatol,2012,4(1):56-60.
    [11] Bashey S,Krathen M,Abdulla F, et al.Romidepsin is effective in subcutaneous panniculitis-like T-cell lymphoma[J].J Clin Oncol, 2012,30(24):e221-225.
    [12] Nagai K, Nakano N, Iwai T, et al. Pediatric subcutaneous panniculitis-like T-cell lymphoma with favorable result by immunosuppressive therapy: a report of two cases[J]. Pediatr Hematol Oncol,2014,31 (6): 528-533.
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Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome

doi: 10.3969/j.issn.1006-0111.2015.04.019
  • Department of Bio-therapy, Eastern Hepatobiliary Surgical Hospital affliated to Second Military Medical University, Shanghai 200438, China
  • Received Date: 2015-02-11
  • Rev Recd Date: 2015-05-14

Abstract: Objective To investigate the clinical features and treatment of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma (SPTCL) associated hemophagocytic syndrome (HPS). Methods A retrospective analysis of case clinical data with liver cirrhosis complicated by SPTCL associated HPS was done in August 2014 in our hospital. Results Because of different phenotypes of T cell receptor (TCR), the aggression, treatment response and prognosis of the disease were significantly different. The patients with HPS had poor treatment effect and short survival period. Conclusion Liver cirrhosis with hepatitis B complicated by SPTCL associated HPS is rare, Bone marrow morphology, pathology, immunohistochemistry and gene rearrangement detection as soon as possible are important for early diagnosis.To control HBV early and effectively is particularly important. Early diagnosis and treatment are important to prolong survival.

YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
Citation: YANG Xijng, ZHOU Fuping, ZHANG Qian, QIAN Qijun. Treatment analysis of liver cirrhosis with hepatitis B complicated by subcutaneous panniculitis-like T-cell lymphoma associated hemophagocytic syndrome[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 363-365. doi: 10.3969/j.issn.1006-0111.2015.04.019
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