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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(4): 376-379

TAN Zhaodan, SHI Kourong, LIU Juan, GU Weiying, CHEN Weicheng. Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 376-379. doi: 10.3969/j.issn.1006-0111.2015.04.023
Citation: TAN Zhaodan, SHI Kourong, LIU Juan, GU Weiying, CHEN Weicheng. Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 376-379. doi: 10.3969/j.issn.1006-0111.2015.04.023
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Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

doi: 10.3969/j.issn.1006-0111.2015.04.023

  • Department of Pharmacy, Seventh People's Hospital of Shanghai, Shanghai 200137, China

  • Received Date: 2014-09-10
  • Rev Recd Date: 2014-12-24
  • Objective To investigate the off-label use of antibacterials in out-patient department and emergency departmentand give reference for management. Methods About 10% of antibacterials prescriptions in out-patient department and emergency department were randomly extracted. Off-label use was analyzed by assessing off-label use percentage, reviewing off-label types and evaluating the rationality. Results 23 600 antibacterial prescriptions, including 43 antibacterials in 9 categorieswere analyzed, and the off-label use percentage of 22.00%. Cephalosporins contributed most in the amount of off-label use prescriptions, while nitroimidazoleseries got the highest off-label percentage of 73.45%. Improper frequency and dosing were the most obvious phenomena, with the ratio of 55.64% and 52.60%, respectively. For oral drugs, most frequent off-label use type of these drugs was improper dosing (72.46%).For injections, frequent off-label use type of these drugs were manifested improper frequency (82.18%) and improper solvent (38.80%). Conclusion Off-label use of antibacterials in hospital was in a critical situation and most of the prescriptions were lack of rational evidence.Standardized administration should be introduced.
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    [4] Tansarlid GS, Rafailidis PI, Kapaskelis A, et al. Frequency of the off-label use of antibiotics in clinical practice: a systematic review[J]. Expert Rev Anti Infect Ther, 2012, 10(12):1383-1392.
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Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients

doi: 10.3969/j.issn.1006-0111.2015.04.023
  • Department of Pharmacy, Seventh People's Hospital of Shanghai, Shanghai 200137, China
  • Received Date: 2014-09-10
  • Rev Recd Date: 2014-12-24

Abstract: Objective To investigate the off-label use of antibacterials in out-patient department and emergency departmentand give reference for management. Methods About 10% of antibacterials prescriptions in out-patient department and emergency department were randomly extracted. Off-label use was analyzed by assessing off-label use percentage, reviewing off-label types and evaluating the rationality. Results 23 600 antibacterial prescriptions, including 43 antibacterials in 9 categorieswere analyzed, and the off-label use percentage of 22.00%. Cephalosporins contributed most in the amount of off-label use prescriptions, while nitroimidazoleseries got the highest off-label percentage of 73.45%. Improper frequency and dosing were the most obvious phenomena, with the ratio of 55.64% and 52.60%, respectively. For oral drugs, most frequent off-label use type of these drugs was improper dosing (72.46%).For injections, frequent off-label use type of these drugs were manifested improper frequency (82.18%) and improper solvent (38.80%). Conclusion Off-label use of antibacterials in hospital was in a critical situation and most of the prescriptions were lack of rational evidence.Standardized administration should be introduced.

TAN Zhaodan, SHI Kourong, LIU Juan, GU Weiying, CHEN Weicheng. Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 376-379. doi: 10.3969/j.issn.1006-0111.2015.04.023
Citation: TAN Zhaodan, SHI Kourong, LIU Juan, GU Weiying, CHEN Weicheng. Investigation and analysis on off-label use of antibacterials for outpatients and emergency patients[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(4): 376-379. doi: 10.3969/j.issn.1006-0111.2015.04.023
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