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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2015  >  33(6): 505-507,543

LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
Citation: LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
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Research progress of adverse drug reaction of quinolone antimicrobial agents

doi: 10.3969/j.issn.1006-0111.2015.06.007
  • 1.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China

  • 2.

    Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China

  • Received Date: 2014-03-03
  • Rev Recd Date: 2014-06-26
  • Quinolones are widely used due to the wide antimicrobial spectrum and strong activity. The common adverse reactions of quinolones include gastrointestinal disturbances, central nervous system reaction, skin reaction, etc. These adverse reactions are mild in severity and self-healing. Since some agents were withdrawn from the market due to severe adverse effects, we should pay more attention to quinolones. Both internal and abroad literatures were reviewed, the adverse effects, the high risk factors of the adverse effects and the application in special population were summarized to provide reference for rational clinical drug use.
  • [1] Tome AM,Filipe A. Quinolones:review of psychiatric and neurological adverse reactions[J]. Drug Saf,2011,34(6):465-484.
    [2] 张霞光,李天云. 喹诺酮类抗菌药在临床使用中的不良反应[J].国外医药(抗生素分册),2003,24:30-33.
    [3] Kim J,Ohtani H,Tsujimoto M. Quantitative comparison of the convulsive activity of ombinations of twelve fluoroquinolones with five nonsteroidal antiinflammatory agents[J].Drug Metab Pharmacok,2009,24(2):167-174.
    [4] 陈翠环,潘宁开. 喹诺酮类药物诱发精神症状的回顾性分析[J].实用医技杂志,2008,15(10):1278-1279.
    [5] 操银针. 喹诺酮类药物引起神经系统不良反应358例分析[J].医药导报,2007,26(10):1246-1247.
    [6] Ray WA,Murray KT,Hall,et al. Azithromycin and the risk of cardiovascular death[J].N Engl J Med,2012,366:1881-1890.
    [7] Lapi F,Wilchesky M, Kezouh A,et al. Fluoroquinolones and the risk of serious arrhythmia: a population-based study[J].Clin Infect Dis,2012,55:1457-65.
    [8] Adefurin A,Sammons H,Jacqz-Aigrain E,et al. Ciprofloxacin safety in paediatrics: a systematic review[J].Arch Dis Child,2011,96:874-80.
    [9] Schaad UB. Will fluoroquinolones ever be recommended for common infections in children?[J].Pediatr Infect Dis J,2007,26:865-867.
    [10] Pichichero ME,Arguedas A, Dagan R,et al. Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure[J].Clin Infect Dis, 2005,41:470-478.
    [11] Seeger JD,West WA,Fife D,et al. Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in amanaged care population[J]. Pharmacoepidemiol Drug Safe,2006,15:784-792.
    [12] Wise BL,Peloquin C,Choi H,et al. Impact of age,obesity,and steroiduse on quinolone-associated tendon disorders[J].Am J Med,2012,125:23-28.
    [13] Mandell LA,Ball P,Tillotson G. Antimicrobial safety and toler ability:differences and dilemmas[J].Clin Infect Dis,2001,32(Suppl):72-79.
    [14] Paterson JM,Mamdani MM, Manno M,et al. Fluoroquinolone therapy and idiosyncratic acute liver injury: a population-based study[J].CMAJ,2012,184:1565-1570.
    [15] Etminan M, Forooghian F,Brophy JM,et al. Oral fluoroquinolones and the risk of retinal detachment[J].JAMA, 201,307:1414-1419.
    [16] Albini TA,Karakousis PC,Abbey AM,et al. Association between oral fluoroquinolones and retinal detachment[J].Am J Ophthalmol, 2012,154:919-921.
    [17] Christ W, Lehnert T,Ulbrich B. Specific toxicologic aspects of the quinolones[J].Rev Infect Dis,1988,10:141-146.
    [18] Kato M,Onodera T. Morphological investigation of cavity formation in articular cartilage induced by ofloxacin in rats[J].Fundam Appl Toxicol,1988,11 (1):110-119.
    [19] Grady R. Safety profile of quinolone antibiotics in the pediatric population[J].Pediatr Infect Dis,2003,22 (12):1128-1132.
    [20] van der Linden PD, Sturkenboom MC, Herings RM,et al. Fluoroquinolones and risk of achilles tendon disorders:case-control study[J].BMJ,2002, 324(7349):1306-1307.
    [21] Shaughnessy MK,Amundson WH, Kuskowski MA,et al. Unnecessary antimicrobial use in patients with current or recent Clostridium difficile infection[J].Infect Control Hosp Epidemiol,2013,34:109-116.
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Research progress of adverse drug reaction of quinolone antimicrobial agents

doi: 10.3969/j.issn.1006-0111.2015.06.007
  • 1. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China;School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China
  • 2. Department of Pharmacy, Fuzhou General Hospital of Nanjing Military Region, Fuzhou 350025, China
  • Received Date: 2014-03-03
  • Rev Recd Date: 2014-06-26

Abstract: Quinolones are widely used due to the wide antimicrobial spectrum and strong activity. The common adverse reactions of quinolones include gastrointestinal disturbances, central nervous system reaction, skin reaction, etc. These adverse reactions are mild in severity and self-healing. Since some agents were withdrawn from the market due to severe adverse effects, we should pay more attention to quinolones. Both internal and abroad literatures were reviewed, the adverse effects, the high risk factors of the adverse effects and the application in special population were summarized to provide reference for rational clinical drug use.

LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
Citation: LIU Qian, ZHANG Jing, LIN Limin, LU Kepeng, SONG Hongtao. Research progress of adverse drug reaction of quinolone antimicrobial agents[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 505-507,543. doi: 10.3969/j.issn.1006-0111.2015.06.007
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