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ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
Citation:
ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism
Jiangxi University of Traditional Chinese Medicine, Nanchang 330000, China;No. 302 Hospital of PLA, Beijing 100039, China
2.
No. 302 Hospital of PLA, Beijing 100039, China
Received Date: 2015-03-20
Rev Recd Date:
2015-07-25
Abstract
Objective To study the anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films (MPH-OFDF) and its mechanism. Methods 60 mice were randomly divided into 6 groups as: normal control group (physiological saline), model group (physiological saline), Yiqiyangxue oral liquids positive group (7.00 mg/kg), MPH-OFDF high-dose group (5.20 mg/kg), MPH-OFDF middle-dose group (2.60 mg/kg) and MPH-OFDF low-dose group (1.30 mg/kg). Besides the normal control group,model group and positive group were orally administered, the other groups are administered with the drug once daily sublingually daily for consecutive 15 days. The mice were put in the load-weighted swimming test 30 min after the last oral administration, then the anti-fatigue effect was assessed based on recording exhausting swimming time and detecting the levels of serum lactale dehydrogenase (LDH), creatine kinase (CK), triglycerides (TG) in mice. Results Compared with control group, the middle-dose and the high-dose MPH could prolong the exhausting swimming time (P<0.05,P<0.01) and decrease the activity of LDH and CK significantly (P<0.05,P<0.01);in addition the middle-dose MPH could decrease the content of TG (P<0.05). Conclusion The MPH had marked anti-fatigue effect that may be associated with reduced serum LDH, CK and TG.
Prommer E. Methylphenidate: established and expanding roles in symptom management [J]. Am J Hosp Palliat Care, 2012, 29:483-490.
[3]
Lower E, Fleishman S, Cooper A, et al. A phase Ⅲ, randomized,placebo-controlled trial of the safety and efficacy of d-MPH as new treatment of fatigue and "chemobrain" in adult cancer patients [J]. Clin Oncol, 2005:23(16S).
[4]
Daniel B, Philippe P, Boudewijn V H, et al. Does methylphenidate reduce the symptoms of chronic fatigue syndrome? [J]. Am J Med,2006, 119(2):e23-e30.
[5]
Shun G, Ping S, Hai J, et al. Effect of methylphenidate in patients with cancer-related fatigue:a systematic review and meta-analysis [J]. PLOS ONE, 2014, 9(1):e84391.
[6]
Aggarwal J, Singh G, Saini S, et al.C.Fast dissolving films a novel approach to oral drug delivery [J]. Int Res J Pharm, 2011, 2(12):69-74.
[7]
Radiloff D, Zhao Y, Boico A, et al. Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude [J]. PLOS One, 2014, 9(6):e99309.
[8]
Thomas DP, Marshall KI. Effect of repeated exhaustive exercise on myocardial subcellular membrane structure [J]. Sports Med, 1988, (9):257-260.
John B, Michael JM, Patricia AR, et al. Imparied calcium pum function does not slow relaxation inhuman skeletal muscle after prolonged exercise [J]. J AppIy Physiol, 1997, 83:511-521.
[12]
Walberg JL, Greenwood MRC, Stern JS. Lipoprotein lipase activity and lpolysis after swim taining in obese Zueker rats [J]. Am J Physiol, 1983, 245:706-712.
Abstract: Objective To study the anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films (MPH-OFDF) and its mechanism. Methods 60 mice were randomly divided into 6 groups as: normal control group (physiological saline), model group (physiological saline), Yiqiyangxue oral liquids positive group (7.00 mg/kg), MPH-OFDF high-dose group (5.20 mg/kg), MPH-OFDF middle-dose group (2.60 mg/kg) and MPH-OFDF low-dose group (1.30 mg/kg). Besides the normal control group,model group and positive group were orally administered, the other groups are administered with the drug once daily sublingually daily for consecutive 15 days. The mice were put in the load-weighted swimming test 30 min after the last oral administration, then the anti-fatigue effect was assessed based on recording exhausting swimming time and detecting the levels of serum lactale dehydrogenase (LDH), creatine kinase (CK), triglycerides (TG) in mice. Results Compared with control group, the middle-dose and the high-dose MPH could prolong the exhausting swimming time (P<0.05,P<0.01) and decrease the activity of LDH and CK significantly (P<0.05,P<0.01);in addition the middle-dose MPH could decrease the content of TG (P<0.05). Conclusion The MPH had marked anti-fatigue effect that may be associated with reduced serum LDH, CK and TG.
ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
Citation:
ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
Prommer E. Methylphenidate: established and expanding roles in symptom management [J]. Am J Hosp Palliat Care, 2012, 29:483-490.
[3]
Lower E, Fleishman S, Cooper A, et al. A phase Ⅲ, randomized,placebo-controlled trial of the safety and efficacy of d-MPH as new treatment of fatigue and "chemobrain" in adult cancer patients [J]. Clin Oncol, 2005:23(16S).
[4]
Daniel B, Philippe P, Boudewijn V H, et al. Does methylphenidate reduce the symptoms of chronic fatigue syndrome? [J]. Am J Med,2006, 119(2):e23-e30.
[5]
Shun G, Ping S, Hai J, et al. Effect of methylphenidate in patients with cancer-related fatigue:a systematic review and meta-analysis [J]. PLOS ONE, 2014, 9(1):e84391.
[6]
Aggarwal J, Singh G, Saini S, et al.C.Fast dissolving films a novel approach to oral drug delivery [J]. Int Res J Pharm, 2011, 2(12):69-74.
[7]
Radiloff D, Zhao Y, Boico A, et al. Anti-hypotensive treatment and endothelin blockade synergistically antagonize exercise fatigue in rats under simulated high altitude [J]. PLOS One, 2014, 9(6):e99309.
[8]
Thomas DP, Marshall KI. Effect of repeated exhaustive exercise on myocardial subcellular membrane structure [J]. Sports Med, 1988, (9):257-260.
John B, Michael JM, Patricia AR, et al. Imparied calcium pum function does not slow relaxation inhuman skeletal muscle after prolonged exercise [J]. J AppIy Physiol, 1997, 83:511-521.
[12]
Walberg JL, Greenwood MRC, Stern JS. Lipoprotein lipase activity and lpolysis after swim taining in obese Zueker rats [J]. Am J Physiol, 1983, 245:706-712.
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ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
ZHANG Lihong, XU Pinghua, WU Na, SHEN Chengying, YUAN Hailong, HAN Jin. Study of anti-fatigue effect of methylphenidate hydrochloride oral fast dissolving films and its mechanism[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 522-524. doi: 10.3969/j.issn.1006-0111.2015.06.011
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