Research progress in the synthesis of tumor-associated carbohydrate antigens (TACAs) GM3 and derivatives

BAI Guojing; BIAN Xiaojie; YAO Kuo; WU Junqi; YU Shichong; MENG Qingguo; WU Qiuye

doi:10.3969/j.issn.1006-0111.2016.01.002

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Glycosylation is the key step of the synthesis of GM3, its reaction conditions are very harsh, the stereoselectivities are usually poor, and the configuration of anomeric carbon is difficult to control. Whether α glycosidic bond can be constructed efficiently in sialylation reactions is an important criteria used to evaluate the reaction quality. Studies of GM3 and derivatives methods generally relates to following areas: the choice of the donor compounds and receptor compounds, the control of stereoselectivity, and the development of some new glycosidic reaction catalyst. In recent years, important progress has been made in this research area. Now, we predominately make a summary and review on the progress of methods for the synthesis of GM3 and derivatives.

Research progress in the synthesis of tumor-associated carbohydrate antigens (TACAs) GM3 and derivatives

1. College of Pharmacy, Yantai University, Yantai 264005, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. College of Pharmacy, Yantai University, Yantai 264005, China

Received Date: 2014-12-03

Rev Recd Date: 2015-03-27

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Abstract: Glycosylation is the key step of the synthesis of GM3, its reaction conditions are very harsh, the stereoselectivities are usually poor, and the configuration of anomeric carbon is difficult to control. Whether α glycosidic bond can be constructed efficiently in sialylation reactions is an important criteria used to evaluate the reaction quality. Studies of GM3 and derivatives methods generally relates to following areas: the choice of the donor compounds and receptor compounds, the control of stereoselectivity, and the development of some new glycosidic reaction catalyst. In recent years, important progress has been made in this research area. Now, we predominately make a summary and review on the progress of methods for the synthesis of GM3 and derivatives.

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Research progress in the synthesis of tumor-associated carbohydrate antigens (TACAs) GM3 and derivatives

doi: 10.3969/j.issn.1006-0111.2016.01.002

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