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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 12-15

DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004
Citation: DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004
shu

Inflammasome and diseases of central nervous system

doi: 10.3969/j.issn.1006-0111.2016.01.004

  • Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-07-09
  • Rev Recd Date: 2015-10-15
  • Inflammasome is the body of protein complex which is able to identify different stimulation signals and can induce immune and inflammatory responses when it is activated. NLRP3 inflammasome has been extensively studied in the central nervous system. Microglia, perivascular macrophages and meningeal macrophages express inflammasomes. The occurrence and development of acute brain infection, aseptic acute brain injury, Parkinson disease and Alzheimer disease are closely related to inflammasomes. Based on mechanisms exploration of the inflammasome's role in the central nervous system disorders, its target drug research and development will be greatly addressed in the future.
  • [1] de Rivero Vaccari JP,Dietrich WD,Keane RW. Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury[J]. J Cereb Blood Flow Metab, 2014, 34(3):369-375.
    [2] Heneka MT, Kummer MP, Andrea Stutz, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice[J]. Nature, 2013, 493(7434):674-678.
    [3] Weber MD, Frank MG, Tracey KJ, et al. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome[J]. J Neurosci, 2015, 35(1):316-324.
    [4] Ying P, Yang CX, Yu ZQ, et al. Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats[J]. Brain Behav Immun, 2014, 41:90-100.
    [5] Cribbs DH, Berchtold NC, Perreau V, et al. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study[J]. J Neuroinflammation, 2012, 9:179-196.
    [6] Shao BZ, Wei W, Ke P, et al. Activating cannabinoid receptor 2 alleviates pathogenesis of experimental autoimmune encephalomyelitis via activation of autophagy and Inhibiting NLRP3 inflammasome[J]. CNS Neurosci Ther, 2014, 20(12):1021-1028.
    [7] Weber MD, Frank MG, Tracey KJ, et al. Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome[J]. J Neurosci, 2015, 35:316-324.
    [8] Walsh JG,Muruve DA,Paver C.Inflammasomes in the CNS[J].Nat Rev Neurosci,2014,15(2):84-97.
    [9] Kumar M, Roe K,Orillo B, et al. Inflammasome adaptor protein apoptosis-associated speck-like protein containing CARD (ASC) is critical for the immune response and survival in West Nile virus encephalitis[J]. Virol, 2013, 87:3655-3667.
    [10] Hoegen T, Tremel N,, et al. The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release[J]. J Immunol, 2011, 187:5440-5451.
    [11] Pradillo JM, Denes A, Greenhalgh AD, et al. Delayed administration of interleukin-1 receptor antagonist reduces ischemic brain damage and inflammation in comorbid rats[J]. J Cereb Blood Flow Metab, 2012, 32:1810-1819.
    [12] Lupfer C, Kanneganti TD. Unsolved Mysteries in NLR Biology[J]. Front Immunol, 2013, 4:285-294.
    [13] Richter K, Kiefer KP, Grzesik BA, et al. Hydrostatic pressure activates ATP-sensitive K+ channels in lung epithelium by ATP release through pannexin and connexin hemichannels[J]. FASEB J, 2014, 28(1):45-55.
    [14] Kampen JMV, Baranowski D, Kay DG. Progranulin gene delivery protects dopaminergic neurons in a mouse model of Parkinson's disease[J]. PLoS One, 2014, 9(5):e97032.
    [15] Codolo G, Plotegher N, Pozzobon T, et al. Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies[J]. PLoS One,2013,8(1):e55375.
    [16] Lu M, Sun XL, Qiao C, et al. Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation[J]. Neurobiology Aging, 2014, 35:421-430.
    [17] Guillot-Sestier MV, Town T. Innate immunity in Alzheimer's disease: a complex affair[J]. CNS Neurol Disord Drug Targets, 2013, 12:593-607.
    [18] Halle A,Hornung V,Petzold GC,et al. The NALP3 inflammassome is involved in the innate immune reponse to amyloid-beta[J].Nat Immunol,2008,9(8):857-865.
    [19] Tan Ms,Yu JT,Jiang T,et al.The NLRP3 inflammasome in Alzheimer's disease[J].Mol Neurobiol,2013,84(3):875-82.
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Inflammasome and diseases of central nervous system

doi: 10.3969/j.issn.1006-0111.2016.01.004
  • Department of Health Toxicology, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-07-09
  • Rev Recd Date: 2015-10-15

Abstract: Inflammasome is the body of protein complex which is able to identify different stimulation signals and can induce immune and inflammatory responses when it is activated. NLRP3 inflammasome has been extensively studied in the central nervous system. Microglia, perivascular macrophages and meningeal macrophages express inflammasomes. The occurrence and development of acute brain infection, aseptic acute brain injury, Parkinson disease and Alzheimer disease are closely related to inflammasomes. Based on mechanisms exploration of the inflammasome's role in the central nervous system disorders, its target drug research and development will be greatly addressed in the future.

DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004
Citation: DU Xiuming, ZHANG Ziteng, ZONG Ying, YU Chenlin, ZHANG Xiaodong, LU Guocai. Inflammasome and diseases of central nervous system[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 12-15. doi: 10.3969/j.issn.1006-0111.2016.01.004
shu

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