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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 44-47

TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
Citation: TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
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Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone

doi: 10.3969/j.issn.1006-0111.2016.01.012
  • 1.

    Xinjiang Medical University, Urumqi 830002, China;Xinjiang Uygur Autonomous Region Institute for Food and Drug Control, Urumqi 830004, China

  • 2.

    Xinjiang Medical University, Urumqi 830002, China

  • Received Date: 2014-12-27
  • Rev Recd Date: 2015-07-21
  • Objective To prepare hot-melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro. Methods SIS HMPSA was used as matrix material, modified Franz diffusion cell and excised female rat skin were used as model,the concentration of progesterone was determined by HPLC. The thickness of patch and penetration enhancers was screened out by permeation rate. Results 2% IPM was used to prepare progesterone HMPSA transdermal patch, thickness was 300 μm, the cumulative permeation curve was Q=6.172 1 t-5.457 7 (r=0.998 8). The cumulative releases of the patches in 24 h was 144.17 μg/cm2. The permeation rate was (6.17±0.49) μg/(cm2·h). Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro, which would have good clinical application prospect.
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    [2] 黄建新,陈超慧.肌肉注射黄体酮局部不良反应的观察及护理[J].当代护士,2007,(1):66-67.
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    [4] 马建芳,罗华菲,王 浩.睾酮热熔压敏胶透皮贴剂的研制[J]. 中国药学杂志,2012,47(21):1727-1731.
    [5] 俞振伟,应晓英,梁文权.热熔压敏胶中药物释放性能的研究[J].中国药学杂志,2009,44(24):1878-1882.
    [6] 王承潇,汤秀珍,沈平婊,等.热熔压敏胶应用于中药贴剂的研究进展[J].中草药,2010,41(3):496-499.
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Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone

doi: 10.3969/j.issn.1006-0111.2016.01.012
  • 1. Xinjiang Medical University, Urumqi 830002, China;Xinjiang Uygur Autonomous Region Institute for Food and Drug Control, Urumqi 830004, China
  • 2. Xinjiang Medical University, Urumqi 830002, China
  • Received Date: 2014-12-27
  • Rev Recd Date: 2015-07-21

Abstract: Objective To prepare hot-melt pressure sensitive adhesive (HMPSA) transdermal patches of progesterone and investigate the release characterization in vitro. Methods SIS HMPSA was used as matrix material, modified Franz diffusion cell and excised female rat skin were used as model,the concentration of progesterone was determined by HPLC. The thickness of patch and penetration enhancers was screened out by permeation rate. Results 2% IPM was used to prepare progesterone HMPSA transdermal patch, thickness was 300 μm, the cumulative permeation curve was Q=6.172 1 t-5.457 7 (r=0.998 8). The cumulative releases of the patches in 24 h was 144.17 μg/cm2. The permeation rate was (6.17±0.49) μg/(cm2·h). Conclusion The progesterone HMPSA transdermal patch had good transdermal release in vitro, which would have good clinical application prospect.

TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
Citation: TAO Hong, CHEN Wenwen, GAO Xiaoli. Preparation and in vitro release characterization of hot-melt pressure sensitive adhesive transdermal patch of progesterone[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 44-47. doi: 10.3969/j.issn.1006-0111.2016.01.012
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