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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(1): 79-82,92

CHEN Bingchen, WANG Sizhen, GUO Beibei, YANG Feng. Synthesis of paclitaxel palmitate and the formulation optimization of its liposomes[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(9): 379-384, 410. doi: 10.12206/j.issn.2097-2024.202404062
Citation: SUN Hui, ZHANG Shasha, LIAN Weiwei. Clinical efficacy of traditional Chinese medicine formula granules of clear heat evil and detoxification in treating hyperuricemia and its safety evaluation[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 79-82,92. doi: 10.3969/j.issn.1006-0111.2016.01.021
shu

Clinical efficacy of traditional Chinese medicine formula granules of clear heat evil and detoxification in treating hyperuricemia and its safety evaluation

doi: 10.3969/j.issn.1006-0111.2016.01.021

  • Department of Immunology, First People's Hospital of Huzhou, Huzhou 313000, China

  • Received Date: 2015-04-24
  • Rev Recd Date: 2015-09-23
  • Objective To evaluate traditional Chinese medicine (TCM) formula granules of clear heat evil and detoxification treating hyperuricemia clinical efficacy and safety through randomized, placebo controlled, blinded clinical trial. Methods 120 patients with hyperuricemia syndrome of damp heat and blood stasis were selected, randomly divided into control and treatment groups, 60 cases in each group, in a period of 4 weeks of treatment and observation. The basic treatment was given to both two groups (diet, exercise etc); in addition, the control group had placebo while treatment group was given TCM clean heat evil and detoxifying formula granules. The clinical efficacy of the products was evaluated by compariment of TCM clinical symptoms before and after treatment as well as serum uric acid,lipids (TC,TG,LDL-C),fasting blood sugar; meanwhile observing complete blood counts (CBC),liver function (ALT,AST),kidney function (BUN,Cr),electrocardiogram (ECG) and adverse reactions to evaluate its safety. Results After 4 weeks of treatment with TCM clear heat evil and detoxifying formula granules,the treatment group symptom total efficiency was 84%,while the placebo control group symptom total efficiency was 25%,the difference is significant statisticly (P<0.001); the treatment group of TCM clean heat evil and detoxifying formula granules significantly reduced in the blood uric acid,compared with before treatment (P<0.01),as well as compared with the placebo control group (P<0.05); after treatment the TCM clear heat evil and detoxifying formula granules significantly reduced in the LDL-C level (P<0.05) compared with before treatment. Comparing before treatment with after treatment,there was no significant difference between the two groups,in routine blood tests,liver and kidney functions,or ECG (P>0.05). There were no side effects or adverse events in either groups in period of treatment and observation. Conclusion TCM clear heat evil and detoxifying formula granules is curative for the hyperuricemia and obviously improve the clinical symptoms for hyperuricemia in patients with damp heat and blood stasis. It is a safe and efficient formulation to reduce uric acid.
  • [1] 黄凤楼,刁孟元,陈学波.29 234 例体检人群血清尿酸水平的流行病学调查[J].中国疗养医学,2011,20(1):83-84.
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    [4] 中国医师协会心血管内科医师分会,中国医师协会循证医学专业委员会.无症状高尿酸血症合并心血管疾病诊治建议中国专家共识[J].中国全科医学,2010,13(11):1145-1149.
    [5] 何 敛.尿酸与人脐静脉血管内皮细胞功能的体外研究[D].北京:北京中医药大学,2010:10-12.
    [6] 唐 盛,吴潮清,王浩宇,等.广西城乡居民高尿酸血症流行病学及与肾损害关系调查分析[J].中国全科医学,2011,14 (29) :3377-3379.
    [7] 李 宁,袁招红,孙蔚华.1 626 例体检人群高尿酸血症患病率及危险因素分析[J]. 赣南医学院学报,2013,33(3):367-369.
    [8] 谢微波,王永红,张明军,等.重庆市 9 528 名体检人群高尿酸血症现状及脂代谢异常、高血压、体重超标关系的研究[J].重庆医科大学学报,2008,33(7):843-846.
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Clinical efficacy of traditional Chinese medicine formula granules of clear heat evil and detoxification in treating hyperuricemia and its safety evaluation

doi: 10.3969/j.issn.1006-0111.2016.01.021
  • Department of Immunology, First People's Hospital of Huzhou, Huzhou 313000, China
  • Received Date: 2015-04-24
  • Rev Recd Date: 2015-09-23

Abstract: Objective To evaluate traditional Chinese medicine (TCM) formula granules of clear heat evil and detoxification treating hyperuricemia clinical efficacy and safety through randomized, placebo controlled, blinded clinical trial. Methods 120 patients with hyperuricemia syndrome of damp heat and blood stasis were selected, randomly divided into control and treatment groups, 60 cases in each group, in a period of 4 weeks of treatment and observation. The basic treatment was given to both two groups (diet, exercise etc); in addition, the control group had placebo while treatment group was given TCM clean heat evil and detoxifying formula granules. The clinical efficacy of the products was evaluated by compariment of TCM clinical symptoms before and after treatment as well as serum uric acid,lipids (TC,TG,LDL-C),fasting blood sugar; meanwhile observing complete blood counts (CBC),liver function (ALT,AST),kidney function (BUN,Cr),electrocardiogram (ECG) and adverse reactions to evaluate its safety. Results After 4 weeks of treatment with TCM clear heat evil and detoxifying formula granules,the treatment group symptom total efficiency was 84%,while the placebo control group symptom total efficiency was 25%,the difference is significant statisticly (P<0.001); the treatment group of TCM clean heat evil and detoxifying formula granules significantly reduced in the blood uric acid,compared with before treatment (P<0.01),as well as compared with the placebo control group (P<0.05); after treatment the TCM clear heat evil and detoxifying formula granules significantly reduced in the LDL-C level (P<0.05) compared with before treatment. Comparing before treatment with after treatment,there was no significant difference between the two groups,in routine blood tests,liver and kidney functions,or ECG (P>0.05). There were no side effects or adverse events in either groups in period of treatment and observation. Conclusion TCM clear heat evil and detoxifying formula granules is curative for the hyperuricemia and obviously improve the clinical symptoms for hyperuricemia in patients with damp heat and blood stasis. It is a safe and efficient formulation to reduce uric acid.

CHEN Bingchen, WANG Sizhen, GUO Beibei, YANG Feng. Synthesis of paclitaxel palmitate and the formulation optimization of its liposomes[J]. Journal of Pharmaceutical Practice and Service, 2024, 42(9): 379-384, 410. doi: 10.12206/j.issn.2097-2024.202404062
Citation: SUN Hui, ZHANG Shasha, LIAN Weiwei. Clinical efficacy of traditional Chinese medicine formula granules of clear heat evil and detoxification in treating hyperuricemia and its safety evaluation[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(1): 79-82,92. doi: 10.3969/j.issn.1006-0111.2016.01.021
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