Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

CHEN Ziqiang; ZHANG Wei; LI Yuping; WANG Xiaoyu

doi:10.3969/j.issn.1006-0111.2016.02.002

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Multidrug resistance(MDR) of tumor cell is the major problem for chemotherapy. However, there is no effective strategy to overcome MDR due to the complicated mechanism. The nano-sized drug delivery system could target to the tumor cell. Moreover, it could delivery different kinds of drugs. Therefore, the nano-sized drug delivery system has become a promising approach to reverse MDR. The nano-sized drug delivery system which is applied to treat the MDR of tumor(osteosarcoma) was summarized and the reverse mechanism was discussed.

Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

1. Department of Orthopaedics, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

2. Department of Pharmacy, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China

3. Department of Pharmacy, Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

Received Date: 2014-12-21

Rev Recd Date: 2015-05-06

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Abstract: Multidrug resistance(MDR) of tumor cell is the major problem for chemotherapy. However, there is no effective strategy to overcome MDR due to the complicated mechanism. The nano-sized drug delivery system could target to the tumor cell. Moreover, it could delivery different kinds of drugs. Therefore, the nano-sized drug delivery system has become a promising approach to reverse MDR. The nano-sized drug delivery system which is applied to treat the MDR of tumor(osteosarcoma) was summarized and the reverse mechanism was discussed.

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Progress on nano-sized drug delivery system reversing tumor and multidrug resistance of osteosarcoma

doi: 10.3969/j.issn.1006-0111.2016.02.002

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