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Volume 34 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2016  >  34(2): 158-162

WANG Linzhao, YUE Lijing, KANG Anfeng, SHE Lan, WANG Huan, MA Zhiqiang, YANG Feng. Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 158-162. doi: 10.3969/j.issn.1006-0111.2016.02.015
Citation: WANG Linzhao, YUE Lijing, KANG Anfeng, SHE Lan, WANG Huan, MA Zhiqiang, YANG Feng. Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 158-162. doi: 10.3969/j.issn.1006-0111.2016.02.015
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Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG

doi: 10.3969/j.issn.1006-0111.2016.02.015
  • 1.

    School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China

  • 2.

    Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2015-10-16
  • Rev Recd Date: 2016-01-21
  • Objective To improve the hydrophobic properties of the ordered mesoporous carbon nanoparticles(MCN) by PVP or DSPE-mPEG2000 modification, and to compare the effect on the dispersion and cytotoxicity of MCN before and after modification. Methods MCN was synthesized by low concentration hydrothermal method. The surface was modified by PVP or DSPE-mPEG2000. The properties of the materials were characterized by transmission electron microscopy(TEM), scanning electron microscopy(SEM), nitrogen sorption analysis, particle size and infrared spectroscopy(IR). The effect on the dispersion of MCN was investigated. CCK-8 method was used to investigate the cytotoxicity of the materials. Flow cytometry was used to investigate the effect of cell oxidative stress. Results The distribution of synthesized MCN was uniform, with average particle size about 90 nm. The particle size and Zeta potential increased slightly after surface modification, while the dispersibility was significantly improved. No significant difference was observed in the toxicity of L929 and HeLa cells before and after modification. However, the modified MCN showed significant effect of reducing production of cellular reactive oxygen species. Conclusion Ordered mesoporous carbon nanoparticles with surface modified by PVP or DSPE-mPEG2000 provide good biocompatibility and can significantly reduce oxidative stress.
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    [2] Sapino S, Ugazio E, Gastaldi L, et al. Mesoporous silica as topical nanocarriers for quercetin:characterization and in vitro studies[J]. Eur J Pharm Biopharm, 2015, 89:116-125.
    [3] Zhu W, Zhao Q, Sun C, et al. Mesoporous carbon with spherical pores as a carrier for celecoxib with needle-like crystallinity:improve dissolution rate and bioavailability[J]. Mater Sci Eng C Mater Biol Appl, 2014, 39:13-20.
    [4] Zhao P, Wang L, Sun C, et al. Uniform mesoporous carbon as a carrier for poorly water soluble drug and its cytotoxicity study[J]. Eur J Pharm Biopharm, 2012, 80(3):535-543.
    [5] 朱杰,廖蕾,朱丽娜,等. 叶酸功能化介孔碳纳米球负载阿霉素的细胞靶向传递及可控释放[J]. 化学学报, 2013, 71(1):69-74.
    [6] Zhang X, Zhang T, Ye Y, et al. Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112(a Hsp90 inhibitor) with enhanced antitumor effect[J]. Eur J Pharm Biopharm, 2015, 94:30-41.
    [7] Zhang Y, Zhao Q, Zhu W, et al. Synthesis and evaluation of mesoporous carbon/lipid bilayer nanocomposites for improved oral delivery of the poorly water-soluble drug, nimodipine[J]. Pharm Res, 2015, 32(7):2372-2383.
    [8] Gu J, Su S, Li Y, et al. Hydrophilic mesoporous carbon nanoparticles as carriers for sustained release of hydrophobic anti-cancer drugs[J]. Chem Commun(Camb), 2011, 47(7):2101-2103.
    [9] Fang Y, Gu D, Zou Y, et al. A low-concentration hydrothermal synthesis of biocompatible ordered mesoporous carbon nanospheres with tunable and uniform size[J]. Angew Chem Int Ed Engl, 2010, 49(43):7987-7991.
    [10] Zhi X, Fang H, Bao C, et al. The immunotoxicity of graphene oxides and the effect of PVP-coating[J]. Biomaterials, 2013, 34(21):5254-5261.
    [11] 王凯苑,孟颖,阎雪莹. PEG-PLGA包裹的介孔碳纳米给药系统的制备和表征[J]. 黑龙江医药, 2015, 28(2):248-251.
    [12] Liang H, Jin C, Tang Y, et al. Cytotoxicity of silica nanoparticles on HaCaT cells[J]. J Appl Toxicol, 2014, 34(4):367-372.
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Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG

doi: 10.3969/j.issn.1006-0111.2016.02.015
  • 1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China
  • 2. Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • 3. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Inorganic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2015-10-16
  • Rev Recd Date: 2016-01-21

Abstract: Objective To improve the hydrophobic properties of the ordered mesoporous carbon nanoparticles(MCN) by PVP or DSPE-mPEG2000 modification, and to compare the effect on the dispersion and cytotoxicity of MCN before and after modification. Methods MCN was synthesized by low concentration hydrothermal method. The surface was modified by PVP or DSPE-mPEG2000. The properties of the materials were characterized by transmission electron microscopy(TEM), scanning electron microscopy(SEM), nitrogen sorption analysis, particle size and infrared spectroscopy(IR). The effect on the dispersion of MCN was investigated. CCK-8 method was used to investigate the cytotoxicity of the materials. Flow cytometry was used to investigate the effect of cell oxidative stress. Results The distribution of synthesized MCN was uniform, with average particle size about 90 nm. The particle size and Zeta potential increased slightly after surface modification, while the dispersibility was significantly improved. No significant difference was observed in the toxicity of L929 and HeLa cells before and after modification. However, the modified MCN showed significant effect of reducing production of cellular reactive oxygen species. Conclusion Ordered mesoporous carbon nanoparticles with surface modified by PVP or DSPE-mPEG2000 provide good biocompatibility and can significantly reduce oxidative stress.

WANG Linzhao, YUE Lijing, KANG Anfeng, SHE Lan, WANG Huan, MA Zhiqiang, YANG Feng. Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 158-162. doi: 10.3969/j.issn.1006-0111.2016.02.015
Citation: WANG Linzhao, YUE Lijing, KANG Anfeng, SHE Lan, WANG Huan, MA Zhiqiang, YANG Feng. Effects on the dispersion and cytotoxicity of ordered mesoporous carbon nanoparticles modified with PVP or PEG[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 158-162. doi: 10.3969/j.issn.1006-0111.2016.02.015
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