Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 35 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(1): 31-35

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
Citation: CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
shu

Preparation of micronized nimodipine push-pull osmotic pump tablets

doi: 10.3969/j.issn.1006-0111.2017.01.008

  • Shanxi Provincial People's Hospital, Taiyuan 030012, China

  • Received Date: 2015-08-25
  • Rev Recd Date: 2016-05-03
  • Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro. The factor f2 was used to evaluate the similarities of different dissolution profiles, and the optimal formulation was performed. Results The micronized nimodipine PPOP controlled release tablets were successfully prepared with excellent zero-order release characteristics. The PPOP tablet's release behavior was close to the zero-order release equation (r=0.998 4). Conclusions The controlled-release formulation was prepared successfully. Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet, the poorly soluble drug, in vitro.
  • [1] Thombre AG,Appel LE,Chidlaw M,et al.Osmotic drug delivery using swellable-core technology[J].J Control Release,2004, 94(1):75-89.
    [2] Langley MS,Sorkin EM.Nimodipine:a view of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in cerebra vascular disease[J].Drugs,1989,37(5):669-699.
    [3] 姜红,金少红.固体药物制剂的溶出度比较[J].中国药事,2000,14(5):326-328.
    [4] 夏锦辉,刘昌孝.固体药物制剂的体外溶出度的统计学评价分析[J].中国药学杂志,2000,35(2):130-131.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3047) PDF downloads(859) Cited by()

Related
Proportional views

Preparation of micronized nimodipine push-pull osmotic pump tablets

doi: 10.3969/j.issn.1006-0111.2017.01.008
  • Shanxi Provincial People's Hospital, Taiyuan 030012, China
  • Received Date: 2015-08-25
  • Rev Recd Date: 2016-05-03

Abstract: Objective To prepare micronized nimodipine push-pull osmotic pump (PPOP) controlled release tablets. Methods The nimodipine as a model drug, micronization technique was applied to the PPOP method. Designed and prepared the controlled release of the nimodipine tablet for 12 hours in vitro. The factor f2 was used to evaluate the similarities of different dissolution profiles, and the optimal formulation was performed. Results The micronized nimodipine PPOP controlled release tablets were successfully prepared with excellent zero-order release characteristics. The PPOP tablet's release behavior was close to the zero-order release equation (r=0.998 4). Conclusions The controlled-release formulation was prepared successfully. Micronized technique combined with the PPOP method significantly increased the release of the nimodipine tablet, the poorly soluble drug, in vitro.

CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
Citation: CHAI Liqing, YAN Airong. Preparation of micronized nimodipine push-pull osmotic pump tablets[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 31-35. doi: 10.3969/j.issn.1006-0111.2017.01.008
shu

    HTML

Reference (4)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return