Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 35 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(1): 36-38,66

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009
Citation: YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009
shu

Study on the micelle properties of montelukast sodium in aqueous solution

doi: 10.3969/j.issn.1006-0111.2017.01.009
  • 1.

    Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

  • 2.

    Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China

  • Received Date: 2016-07-30
  • Rev Recd Date: 2016-11-13
  • Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.
  • [1] 李国胜, 王海燕, 杨红娟.孟鲁司特钠片的循证应用[J].山西医药杂志, 2016, 45(10):1174-1178.
    [2] Kabir-Ud-Din, Al-Ahmadi MD, Naqvi AZ, et al. Conductometric study of antidepressant drug-cationic surfactant mixed micelles in aqueous solution[J]. Colloids Surf B:Biointerfaces, 2008, 64(1):65-69.
    [3] 韩丽梅, 王卓, 邓英杰,等.用透光率评价分散片混悬性的方法[J].药物分析杂志, 1996,16(6):396-397.
    [4] 赵国玺.表面活性剂物理化学[M]. 北京:北京大学出版社, 1991:190-192.
    [5] Attwood DT.Surfactant Systems Their Chemistry, Pharmacy and Biology[M]. London:Chapman & Hall,1983:72-117.
    [6] Causon D, Gettins J, Gormally J, et al.Ultrasonic relaxations associated with aggregation in drugs[J]. J Chem Soc Faraday Trans, 1981, 77(1):143-151.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2921) PDF downloads(798) Cited by()

Related
Proportional views

Study on the micelle properties of montelukast sodium in aqueous solution

doi: 10.3969/j.issn.1006-0111.2017.01.009
  • 1. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
  • 2. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China
  • Received Date: 2016-07-30
  • Rev Recd Date: 2016-11-13

Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009
Citation: YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009
shu

    HTML

Reference (6)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return