The application of dynastat in hepatic cancer patients after liver resection

LIN Hui; YANG Yuan; WANG Zhihong; LIN Chuan; ZHOU Weiping

doi:10.3969/j.issn.1006-0111.2017.01.018

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Objective To investigate the analgesia effects of dynastat in hepatic cancer patients after liver resection. Methods From June to December of year 2015, we collected 200 cases of hepatic cancer operation in the Eastern Hepatobiliary Surgery Hospital retrospectively. Those patients were divided into 2 groups (the dynastat treated group, n=100; the untreated group, n=100).The patients in treated group were given dynastat 3 times (40 mg/5 ml,iv, 6 hours,18 hours and 30 hours after operation respectively), while the control group did not received any dynastat. The sufentanil analgesia pumps were used in both groups. The treated group received a lower sufentanil dose. The pain severity (VAS score) of patients and the postoperative untoward effects were compared between these two groups. The results were analyzed statistically. Results The VAS score and the postoperative untoward effects of the treated group were clearly lower than the control group. All differences have statistical significance(P<0.05) Conclusions As a new-type selective COX-2 inhibitor for injection, dynastat can reduce the dosage and side effects of opioid medicine. It deserves to be popularized in post operation analgesia.

The application of dynastat in hepatic cancer patients after liver resection

1. Shidong Hospital, Yangpu District, Shanghai 200438

2. Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China

Received Date: 2016-09-03

Rev Recd Date: 2016-11-07

Key words:

hepatectomy /
analgesia /
dynastat

Abstract: Objective To investigate the analgesia effects of dynastat in hepatic cancer patients after liver resection. Methods From June to December of year 2015, we collected 200 cases of hepatic cancer operation in the Eastern Hepatobiliary Surgery Hospital retrospectively. Those patients were divided into 2 groups (the dynastat treated group, n=100; the untreated group, n=100).The patients in treated group were given dynastat 3 times (40 mg/5 ml,iv, 6 hours,18 hours and 30 hours after operation respectively), while the control group did not received any dynastat. The sufentanil analgesia pumps were used in both groups. The treated group received a lower sufentanil dose. The pain severity (VAS score) of patients and the postoperative untoward effects were compared between these two groups. The results were analyzed statistically. Results The VAS score and the postoperative untoward effects of the treated group were clearly lower than the control group. All differences have statistical significance(P<0.05) Conclusions As a new-type selective COX-2 inhibitor for injection, dynastat can reduce the dosage and side effects of opioid medicine. It deserves to be popularized in post operation analgesia.

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Reference (10)

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The application of dynastat in hepatic cancer patients after liver resection

doi: 10.3969/j.issn.1006-0111.2017.01.018

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