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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2017  >  35(4): 298-300,314

XIE Fahong, HUANG Zhi, ZHANG Haoyu, LI Dedong. Adverse reactions in hematological system induced by antibacterial agents[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 298-300,314. doi: 10.3969/j.issn.1006-0111.2017.04.003
Citation: XIE Fahong, HUANG Zhi, ZHANG Haoyu, LI Dedong. Adverse reactions in hematological system induced by antibacterial agents[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 298-300,314. doi: 10.3969/j.issn.1006-0111.2017.04.003
shu

Adverse reactions in hematological system induced by antibacterial agents

doi: 10.3969/j.issn.1006-0111.2017.04.003

  • Clinical Pharmacy Center, Department of Pharmacy, PLA General Hospital, Beijing 100853, China

  • Received Date: 2016-12-06
  • Rev Recd Date: 2017-05-03
  • In recent years, with the wide use of antimicrobial agents, the adverse reactions related to antimicrobial agents have attracted more and more attention.Among them, the adverse reactions in hematological system induced by antibacterial agents seriously affect patient's health and doctor's selection for antibiotics.For example, some beta lactam antibiotics can cause dysfunction of coagulation and hemolytic anemia.Chloramphenicol and sulfonamides can cause aplastic anemia.Linezolid can cause thrombocytopenia and anemia.It is important to understand the adverse reactions in hematological system caused by antibiotics.In this paper, the antibiotic induced adverse reactions in hematological system and their mechanism were summarized in order to provide information for the rational use of antimicrobial agents.
  • [1] Yilmaz C, Ozcengiz G.Antibiotics: Pharmacokinetics, toxicity, resistance and multidrug efflux pumps[J].Biochem Pharmacol, 2017,133:43-62.
    [2] De Wilde M, Speeckaert M, Callens R, et al.Ceftriaxone-induced immune hemolytic anemia as a life-threatening complication of antibiotic treatment of "chronic Lyme disease"[J].Acta Clin Belg, 2017,72(2):133-137.
    [3] Hanai Y, Matsuo K, Ogawa M, et al.A retrospective study of the risk factors for linezolid-induced thrombocytopenia and anemia[J].J Infect Chemother, 2016,22(8):536-542.
    [4] Wong RS, Cheng G, Chan NP, et al.Use of cefoperazone still needs a caution for bleeding from induced vitamin K deficiency[J].Am J Hematol, 2006,81(1):76.
    [5] Garratty G.Immune hemolytic anemia caused by drugs[J].Expert Opin Drug Saf, 2012,11(4):635-642.
    [6] Macy E.Penicillin and beta-lactam allergy: epidemiology and diagnosis[J].Curr Allergy Asthma Rep, 2014,14(11):476.
    [7] 张 兵, 冯变玲, 赵晓红, 等.青霉素类药物不良反应报告分析[J].西北药学杂志, 2013,28(5):524-526.
    [8] 张小林.β-内酰胺类抗生素对血液系统的影响[J].国际输血及血液学杂志, 1997,20(2):68-71.
    [9] Ruiz-Irastorza G, Barreiro G,Aguirre C.Reversible bone marrow depression by high-dose piperacillin/tazobactam[J].Br J Haematol, 1996,95(4):611-612.
    [10] 李楚倩, 周陈西, 刘孟娟, 等.第3代头孢菌素致血液系统不良反应文献分析[J].中国药业, 2012,21(24):98-100.
    [11] Shearer MJ, Bechtold H, Andrassy K, et al.Mechanism of cephalosporin-induced hypoprothrombinemia: relation to cephalosporin side chain, vitamin K metabolism, and vitamin K status[J].J Clin Pharmacol, 1988,28(1):88-95.
    [12] Neuman G, Boodhan S, Wurman I, et al.Ceftriaxone-induced immune hemolytic anemia[J].Ann Pharmacother, 2014,48(12):1594-1604.
    [13] 刘代红.药物诱发的免疫性溶血性贫血[J].中国实用内科杂志, 2012,32(5):338-339.
    [14] Garratty G.Drug-induced immune hemolytic anemia[J].Clin Adv Hematol Oncol, 2010,8(2): 98-101.
    [15] Kim S, Song KS, Kim HO, et al.Ceftriaxone induced immune hemolytic anemia: detection of drug-dependent antibody by ex-vivo antigen in urine[J].Yonsei Med J, 2002, 43(3):391-394.
    [16] Robinson HE, Maxwell EL, Prince HM, et al.Cefotetan-induced life-threatening haemolysis[J].Med J Aust, 2006,184(5):251.
    [17] 云 璐, 王 帅, 李 杰.注射用拉氧头孢钠引起凝血障碍1例[J].中国现代应用药学, 2012,29(9):860-860.
    [18] Cazzola M, Brancaccio V, De Giglio C, et al.Flomoxef, a new oxacephem antibiotic, does not cause hemostatic defects[J].Int J Clin Pharmacol Ther Toxicol, 1993,31(3):148-152.
    [19] 吴 昕.临床应用氯霉素的不良反应[J].临床合理用药杂志, 2008,1(1):36-37.
    [20] Turton JA, Andrews CM, Havard AC, et al.Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat[J].Food Chem Toxicol, 2002,40(12):1849-1861.
    [21] 马 勤, 黄滔敏.眼用制剂致不良反应208例文献分析[J].中国药房, 2013,24(44):4192-4195.
    [22] 孙元玲.氯霉素滴眼液致再生障碍性贫血1例[J].中国药事, 2000,14(2):136.
    [23] Leiter LM, Thatte HS, Okafor C, et al.Chloramphenicol-induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions[J].J Cell Physiol, 1999,180(3): 334-344.
    [24] Harthan AA,Heger ML.Stenotrophomonas infection in a patient with glucose-6-phosphate dehydrogenase deficiency[J].J Pediatr Pharmacol Ther, 2013,18(2): 137-141.
    [25] 王 静, 赵 睿, 李明芬.复方新诺明的少见不良反应[J].中国药业, 2006,15(3): 77-78.
    [26] 张爱芬, 郝敬旺, 项林海.磺胺类药物不良反应及应对措施分析[J].临床医学研究与实践, 2016,1(20): 20-21.
    [27] Gorchynski J, Rose JK.Complications of MRSA treatment: linezolid-induced myelosuppression presenting with pancytopenia[J].West J Emerg Med, 2008,9(3):177-178.
    [28] Bernstein WB, Trotta RF, Rector JT, et al.Mechanisms for linezolid-induced anemia and thrombocytopenia[J].Ann Pharmacother, 2003,37(4):517-520.
    [29] Dawson MA, Davis A, Elliott P, et al.Linezolid-induced dyserythropoiesis: chloramphenicol toxicity revisited[J].Intern Med J, 2005,35(10):626-628.
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Adverse reactions in hematological system induced by antibacterial agents

doi: 10.3969/j.issn.1006-0111.2017.04.003
  • Clinical Pharmacy Center, Department of Pharmacy, PLA General Hospital, Beijing 100853, China
  • Received Date: 2016-12-06
  • Rev Recd Date: 2017-05-03

Abstract: In recent years, with the wide use of antimicrobial agents, the adverse reactions related to antimicrobial agents have attracted more and more attention.Among them, the adverse reactions in hematological system induced by antibacterial agents seriously affect patient's health and doctor's selection for antibiotics.For example, some beta lactam antibiotics can cause dysfunction of coagulation and hemolytic anemia.Chloramphenicol and sulfonamides can cause aplastic anemia.Linezolid can cause thrombocytopenia and anemia.It is important to understand the adverse reactions in hematological system caused by antibiotics.In this paper, the antibiotic induced adverse reactions in hematological system and their mechanism were summarized in order to provide information for the rational use of antimicrobial agents.

XIE Fahong, HUANG Zhi, ZHANG Haoyu, LI Dedong. Adverse reactions in hematological system induced by antibacterial agents[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 298-300,314. doi: 10.3969/j.issn.1006-0111.2017.04.003
Citation: XIE Fahong, HUANG Zhi, ZHANG Haoyu, LI Dedong. Adverse reactions in hematological system induced by antibacterial agents[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 298-300,314. doi: 10.3969/j.issn.1006-0111.2017.04.003
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